{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:04:56Z","timestamp":1790697896848,"version":"4.1.0"},"reference-count":37,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T00:00:00Z","timestamp":1772409600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100001818","name":"Research to Prevent Blindness","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001818","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["K23 Grant"],"award-info":[{"award-number":["K23 Grant"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["K23EY035741"],"award-info":[{"award-number":["K23EY035741"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010310","name":"E. Matilda Ziegler Foundation for the Blind","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010310","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Alan and Irene Adler Initiative in Ocular Oncology"},{"name":"P30 Vision Research Core","award":["Grant (NEI P30EY026877)"],"award-info":[{"award-number":["Grant (NEI P30EY026877)"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of VitreoRetinal Diseases"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:p>\n                    <jats:bold>Purpose:<\/jats:bold>\n                    To compare systemic comorbidities in bilateral retinal telangiectasia, a proxy for macular telangiectasia (MacTel) type 2, vs matched controls.\n                    <jats:bold>Methods:<\/jats:bold>\n                    We conducted a retrospective cohort study of a large electronic health research network of patients who were older than 45 years at bilateral retinal telangiectasia diagnosis vs controls receiving eye care. Patients with macular edema or exudative age-related macular degeneration were excluded. Propensity score matching was performed on demographics. The prevalence of hypertension, diabetes mellitus, obesity, hyperlipidemia, and death within 5 years of retinal telangiectasia diagnosis or eye care visit were compared.\n                    <jats:bold>Results:<\/jats:bold>\n                    2320 patients with bilateral retinal telangiectasia and 1\u2009671\u2009600 patients with an eye care visit were included. After matching, no demographic differences persisted. Bilateral retinal telangiectasia (vs control) patients had higher rates of type 2 diabetes mellitus (32.8% vs 20.7%; odds ratio [OR], 1.87; 95% CI, 1.64-2.14;\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; .005) and obesity (19.9% vs 16.9%; OR 1.22; 95% CI:1.05-1.42;\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = .01) and a lower rate of hyperlipidemia (32.0% vs 39.5%; OR 0.71; 95% CI, 0.63-0.80;\n                    <jats:italic toggle=\"yes\">P &lt; .<\/jats:italic>\n                    005). No differences occurred in hypertension or death rates.\n                    <jats:bold>Conclusions:<\/jats:bold>\n                    Retinal telangiectasia and MacTel type 2 are uncommon and poorly understood, with high coexisting rates of diabetes and obesity. Systemic disease associations should be investigated to identify disease interactions, the impact of systemic interventions, and leads for potential new treatments.\n                  <\/jats:p>","DOI":"10.1177\/24741264261423313","type":"journal-article","created":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T12:36:37Z","timestamp":1772454997000},"page":"664-671","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Prevalence of Systemic Comorbidities and Ocular Complications in Patients With Bilateral Retinal Telangiectasia"],"prefix":"10.1177","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9925-2985","authenticated-orcid":false,"given":"Cindy S.","family":"Zhao","sequence":"first","affiliation":[{"name":"Byers Eye Institute at Stanford Health Care, Palo Alto, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana V.","family":"Do","sequence":"additional","affiliation":[{"name":"Byers Eye Institute at Stanford Health Care, Palo Alto, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven R.","family":"Sanislo","sequence":"additional","affiliation":[{"name":"Byers Eye Institute at Stanford Health Care, Palo Alto, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chase","family":"Ludwig","sequence":"additional","affiliation":[{"name":"Byers Eye Institute at Stanford Health Care, Palo Alto, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ehsan","family":"Rahimy","sequence":"additional","affiliation":[{"name":"Byers Eye Institute at Stanford Health Care, Palo Alto, CA, USA"},{"name":"Palo Alto Medical Foundation, Palo Alto, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1087-9736","authenticated-orcid":false,"given":"Prithvi","family":"Mruthyunjaya","sequence":"additional","affiliation":[{"name":"Byers Eye Institute at Stanford Health Care, Palo Alto, CA, USA"},{"name":"Byers Eye Institute at Stanford University, Alan Adler Center for Ophthalmic Oncology, Palo Alto, CA, USA"},{"name":"Department of Radiation Oncology, Stanford Health Care, Palo Alto, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8980-2242","authenticated-orcid":false,"given":"Karen M.","family":"Wai","sequence":"additional","affiliation":[{"name":"Byers Eye Institute at Stanford Health Care, Palo Alto, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,3,2]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1982.01030030773010"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(93)31447-8"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S373538"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2012.11.002"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2020.03.040"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e3181bd2c71"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2010.02.013"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.3109\/09286580903450361"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1986.01050130081025"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(86)90012-7"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.124.4.450"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(99)90523-7"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2023.6454"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.3109\/09286586.2013.766757"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.4103\/ijo.IJO_85_17"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.oret.2021.01.002"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40942-017-0103-x"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-69164-y"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2011-301009"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2009.02.006"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2010.04.001"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.12-10765"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.12-10580"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.17-21834"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000001450"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000000093"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2004.06.010"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e31814cf03e"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e31818ba9de"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2018.09.041"},{"key":"e_1_3_2_32_2","unstructured":"Ferguson 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Neurotech\u2019s ENCELTO\u2122 (revakinagene taroretcel-lwey) approved by the FDA for the treatment of adults with idiopathic macular telangiectasia Type 2 (MacTel). neurotech. March 6 2025. 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