{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:05:39Z","timestamp":1790697939044,"version":"4.1.0"},"reference-count":24,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T00:00:00Z","timestamp":1775174400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T00:00:00Z","timestamp":1775174400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100001818","name":"Research to Prevent Blindness","doi-asserted-by":"publisher","award":["GR004596"],"award-info":[{"award-number":["GR004596"]}],"id":[{"id":"10.13039\/100001818","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30EY014801"],"award-info":[{"award-number":["P30EY014801"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of VitreoRetinal Diseases"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:p>\n                    <jats:bold>Purpose:<\/jats:bold>\n                    To report an adult case of familial exudative vitreoretinopathy (FEVR) initially resembling high myopia\u2013associated retinal pathology.\n                    <jats:bold>Methods:<\/jats:bold>\n                    A single case was reviewed.\n                    <jats:bold>Results:<\/jats:bold>\n                    An adult man with a history of high myopia and recurrent retinal detachments presented with temporal retinal atrophy, vessel straightening, and a large nasal retinal detachment with fibrosis and proliferative vitreoretinopathy (PVR) on dilated fundus examination. Fluorescein angiography (FA) demonstrated peripheral retinal nonperfusion. The patient underwent vitreoretinal surgery with adjunctive intravitreal methotrexate. Genetic testing identified a pathogenic heterozygous\n                    <jats:italic toggle=\"yes\">FZD4<\/jats:italic>\n                    variant (p.Trp494*), confirming the diagnosis of FEVR. Although FEVR is a rare inherited retinal vascular disorder typically diagnosed in childhood, adult presentations may be misattributed to degenerative myopia, particularly in the presence of overlapping features such as staphylomas, macular atrophy, and retinal detachment.\n                    <jats:bold>Conclusions:<\/jats:bold>\n                    This case highlights the importance of FA and genetic testing in distinguishing inherited retinal disease from degenerative disease. Greater clinical awareness and access to molecular diagnostics may facilitate earlier recognition and improve the management of atypical retinal detachment in adults.\n                  <\/jats:p>","DOI":"10.1177\/24741264261430900","type":"journal-article","created":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T05:51:57Z","timestamp":1775281917000},"page":"1097-1100","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Complex Retinal Detachment in an Adult Patient With Familial Exudative Vitreoretinopathy: Challenges in Diagnosis and Management"],"prefix":"10.1177","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-6977-5348","authenticated-orcid":false,"given":"Chioma","family":"Amuzie","sequence":"first","affiliation":[{"name":"University of Miami Miller School of Medicine, Miami, FL, USA"},{"name":"Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1955-9707","authenticated-orcid":false,"given":"Gelila","family":"Yohannes","sequence":"additional","affiliation":[{"name":"University of Miami Miller School of Medicine, Miami, FL, USA"},{"name":"Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherin I.","family":"Negron","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audina M.","family":"Berrocal","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,4,3]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(69)91237-9"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(14)76893-X"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004397-199303320-00022"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1080\/13816810.2019.1686157"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2011.06.020"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.oret.2019.04.023"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10384-005-0249-1"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2015.05.036"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.65.4.1"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1080\/13816810.2022.2116648"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2013.08.010"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2014.05.029"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2010.190116"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1080\/13816810490514270"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0271326"},{"key":"e_1_3_3_17_2","first-page":"917","article-title":"Novel mutations in FZD4 and phenotype-genotype correlation in Chinese patients with familial exudative vitreoretinopathy","volume":"22","author":"Tang M","year":"2016","unstructured":"Tang M, Ding X, Li J, et al. Novel mutations in FZD4 and phenotype-genotype correlation in Chinese patients with familial exudative vitreoretinopathy. Mol Vis. 2016;22:917-932.","journal-title":"Mol Vis"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.87.10.1291"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.3928\/23258160-20220920-04"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S111893"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1177\/24741264221076357"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1177\/24741264221135799"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000004046"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41433-024-03503-5"},{"key":"e_1_3_3_25_2","unstructured":"Aldeyra Therapeutics Inc. 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