{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:36:53Z","timestamp":1792787813847,"version":"4.5.0"},"reference-count":28,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T00:00:00Z","timestamp":1783123200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"clinical trial at Retina Partners Midwest","id":[{"id":"https:\/\/ror.org\/051vsps84","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of VitreoRetinal Diseases"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:p>\n                    <jats:bold>Purpose:<\/jats:bold>\n                    To assess the treatment effect of AVD-104 in eyes with geographic atrophy (GA) secondary to dry age-related macular degeneration (AMD) by multifocal electroretinography (mfERG) and evaluate mfERG as a potential clinical endpoint in dry AMD studies.\n                    <jats:bold>Methods:<\/jats:bold>\n                    This prospective case series included 6 patients enrolled in part 1 of the phase 2\/3 SIGLEC clinical trial, all of whom were diagnosed with advanced bilateral GA. Subjects received a single intravitreal injection of AVD-104 in the study eye. At a screening visit, baseline, and months 1, 2, and 3, mfERG testing and best-corrected visual acuity (BCVA) were collected in the study eyes. mfERG testing was also collected at a screening visit, baseline, and month 3 in fellow eyes. We analyzed the overall N1-P1 response density, overall P1 implicit time, junctional N1-P1 response density, and junctional P1 implicit time at each visit.\n                    <jats:bold>Results:<\/jats:bold>\n                    After AVD-104 treatment, the largest improvements in mean overall N1-P1 response density and junctional N1-P1 response density occurred at month 2, with gains of 17.1% (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = .47) and 40.1% (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = .01), respectively. Five of 6 study eyes achieved a greater than 20% gain in mean junctional N1-P1 response density at month 2, and 3 study eyes maintained more than a 20% gain at month 3. Mean BCVA also improved incrementally at each follow-up visit, reaching +6.0 letters over baseline at month 3 (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = .04).\n                    <jats:bold>Conclusions:<\/jats:bold>\n                    mfERG and BCVA data supported the benefit of AVD-104 treatment in eyes with GA and revealed the potential to recover retinal function in the junctional zone 2 months after treatment.\n                  <\/jats:p>","DOI":"10.1177\/24741264261438431","type":"journal-article","created":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T14:17:43Z","timestamp":1783174663000},"page":"987-996","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Multifocal Electroretinography Outcomes Following AVD-104 Treatment for Geographic Atrophy"],"prefix":"10.1177","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-7226-1615","authenticated-orcid":false,"given":"Nathan N.","family":"Macha","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, IN, USA"},{"name":"Retina Partners Midwest and Midwest Eye Institute, Carmel, IN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minzhong","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University Hospitals, Case Western Reserve University School of Medicine, Cleveland, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheeraz","family":"Naqvi","sequence":"additional","affiliation":[{"name":"Retina Partners Midwest and Midwest Eye Institute, Carmel, IN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Birch","sequence":"additional","affiliation":[{"name":"Retina Foundation of the Southwest, Dallas, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Tolentino","sequence":"additional","affiliation":[{"name":"Aviceda Therapeutics, Cambridge, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1642-2430","authenticated-orcid":false,"given":"David","family":"Callanan","sequence":"additional","affiliation":[{"name":"Aviceda Therapeutics, Cambridge, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8894-1846","authenticated-orcid":false,"given":"Raj K.","family":"Maturi","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, IN, USA"},{"name":"Retina Partners Midwest and Midwest Eye Institute, Carmel, IN, 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