{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:04:58Z","timestamp":1790697898385,"version":"4.1.0"},"reference-count":28,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T00:00:00Z","timestamp":1780012800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of VitreoRetinal Diseases"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:p>\n                    <jats:bold>Purpose:<\/jats:bold>\n                    To compare the effectiveness of antivascular endothelial growth factor (anti-VEGF) therapy with or without panretinal photocoagulation (PRP) on retinal neovascularization (NV) in patients with proliferative diabetic retinopathy (PDR) at 24 months.\n                    <jats:bold>Methods:<\/jats:bold>\n                    This retrospective, multicenter, observational case series included 237 patients (307 eyes) with retinal NV secondary to PDR treated with anti-VEGF.\n                    <jats:bold>Results:<\/jats:bold>\n                    Eyes were divided into 2 groups: eyes with prior PRP (group A, 162 eyes) and treatment-na\u00efve eyes (group B, 145 eyes). Group A received a mean of 4.5 anti-VEGF injections per eye (95% CI, 4.1-5.1) and group B a mean of 5.8 (95% CI, 5.3-6.3) during follow-up. Both groups showed significant improvements in best-corrected visual acuity and central macular thickness. Mean visual acuity in group A improved from 20\/125 to 20\/60 (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; .001) and in group B from 20\/100 to 20\/60 (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = .002). Mean central macular thickness decreased in group A from 341.8\u202f\u00b5m (95% CI, 327.2-358.1) to 285.3\u202f\u00b5m (95% CI, 273.2-296.4;\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; .001) and in group B from 346.1\u202f\u00b5m (95% CI, 322.6-365.5) to 298.1\u202f\u00b5m (95% CI, 276.2-319.1;\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; .001). In group A, 127 eyes (78.4%) responded to anti-VEGF alone. In group B, only 23 eyes (15.8%) achieved complete or partial regression with anti-VEGF alone, while 122 (84.1%) required additional PRP or vitrectomy. Pars plana vitrectomy was performed in 6.7% of group A eyes and 12.4% of group B eyes. Main indications were vitreous hemorrhage and tractional retinal detachment in both groups.\n                    <jats:bold>Conclusions:<\/jats:bold>\n                    Antiangiogenic therapy resulted in marked regression of retinal NV in patients with PDR and previous PRP. A combined approach of antiangiogenics plus PRP should be studied.\n                  <\/jats:p>","DOI":"10.1177\/24741264261438454","type":"journal-article","created":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T13:21:10Z","timestamp":1780060870000},"page":"837-846","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Comparison of Intravitreal Antivascular Endothelial Growth Factor Therapy in Treatment-Na\u00efve vs Panretinal Photocoagulation\u2013Treated Eyes With Proliferative Diabetic Retinopathy"],"prefix":"10.1177","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6104-5737","authenticated-orcid":false,"given":"J. Fernando","family":"Arevalo","sequence":"first","affiliation":[{"name":"Retina Division, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9602-9769","authenticated-orcid":false,"given":"Andres F.","family":"Lasave","sequence":"additional","affiliation":[{"name":"Retina and Vitreous Department, Clinica Privada de Ojos, Mar del Plata, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3387-7058","authenticated-orcid":false,"given":"Lihteh","family":"Wu","sequence":"additional","affiliation":[{"name":"Asociados de Macula Vitreo y Retina de Costa Rica, San Jose, Costa Rica"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arturo","family":"Alezzandrini","sequence":"additional","affiliation":[{"name":"Facultad de Medicina, OFTALMOS, Universidad de Buenos Aires, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rufino","family":"Silva","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Centro Hospitalar e Universit\u00e1rio de Coimbra (CHUC), Coimbra, Portugal"},{"name":"Faculty of Medicine, Clinical Academic Center of Coimbra (CACC), University of Coimbra, Coimbra, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1855-1964","authenticated-orcid":false,"given":"Nuno","family":"Gouveia","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Centro Hospitalar e Universit\u00e1rio de Coimbra (CHUC), Coimbra, Portugal"},{"name":"Faculty of Medicine, Clinical Academic Center of Coimbra (CACC), University of Coimbra, Coimbra, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan D.","family":"Arias","sequence":"additional","affiliation":[{"name":"FOSCAL Internacional, Floridablanca, Santander, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9942-3868","authenticated-orcid":false,"given":"Dayron F.","family":"Martinez","sequence":"additional","affiliation":[{"name":"FOSCAL Internacional, Floridablanca, Santander, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos M.","family":"Cordoba","sequence":"additional","affiliation":[{"name":"FOSCAL Internacional, Floridablanca, Santander, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauricio","family":"Maia","sequence":"additional","affiliation":[{"name":"Vitreo-Retina Service, Federal University of S\u00e3o Paulo, S\u00e3o Paolo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Brito","sequence":"additional","affiliation":[{"name":"Instituto Docente de Especialidades Oftalmol\u00f3gicas (IDEO), Maracaibo, Venezuela"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose","family":"Romero","sequence":"additional","affiliation":[{"name":"Instituto Docente de Especialidades Oftalmol\u00f3gicas (IDEO), Maracaibo, Venezuela"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo","family":"H\u00fcning","sequence":"additional","affiliation":[{"name":"H\u00fcning Cl\u00ednica do Olhar, Santa Maria, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajeev H.","family":"Muni","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, ON, Canada"},{"name":"Department of Ophthalmology, St Michael\u2019s Hospital, Unity Health Toronto, Toronto, ON, Canada"},{"name":"Kensington Vision and Research Institute, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aurora","family":"Pecaku","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, ON, Canada"},{"name":"Department of Ophthalmology, St Michael\u2019s Hospital, Unity Health Toronto, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabela Martins","family":"Melo","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, ON, Canada"},{"name":"Department of Ophthalmology, St Michael\u2019s Hospital, Unity Health Toronto, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Rojas","sequence":"additional","affiliation":[{"name":"Hospital de la Luz, Mexico City, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the Pan-American Collaborative Retina Study Group (PACORES)","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,5,29]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.2174\/157339912800840488"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e318042d32c"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S47780"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2014.13"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.33.23463"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1080\/08820538.2016.1228397"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.15217"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000001181"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2017.0969"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.00849"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/aos.14681"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.3310\/PCGV5709"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)31193-5"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2018.3255"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/aos.14312"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006982-200603000-00016"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.29271\/jcpsp.2018.12.923"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000003450"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.5935\/0004-2749.20220006"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(91)32085-2"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(13)38011-7"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00921112"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0420.1995.tb00031.x"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2011.05.035"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2020.03.011"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2019.03.005"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2018.07.027"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(14)75794-0"}],"container-title":["Journal of VitreoRetinal Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/24741264261438454","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/24741264261438454","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/24741264261438454","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T15:24:58Z","timestamp":1790695498000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/24741264261438454"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,29]]},"references-count":28,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1177\/24741264261438454"],"URL":"https:\/\/doi.org\/10.1177\/24741264261438454","relation":{},"ISSN":["2474-1264","2474-1272"],"issn-type":[{"value":"2474-1264","type":"print"},{"value":"2474-1272","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,29]]}}}