{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:36:53Z","timestamp":1792787813809,"version":"4.5.0"},"reference-count":29,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T00:00:00Z","timestamp":1778803200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"National Institute of Health","award":["NIH grant P30 EY003790."],"award-info":[{"award-number":["NIH grant P30 EY003790."]}]},{"name":"Drusolv Therapeutics, Sumitomo Pharma America, Inc, ONL Therapeutics, QLT, Bausch and Lomb, Massachusetts Eye and Ear Clinical Data Science Institute, and Lowy Medical Research Institute","id":[{"id":"https:\/\/ror.org\/01jgzvw27","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Massachusetts Eye and Ear Clinical Data Science Institute"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of VitreoRetinal Diseases"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:p>\n                    <jats:bold>Purpose:<\/jats:bold>\n                    To investigate the prevalence and characteristics of cystoid macular edema (CME) in patients with retinitis pigmentosa (RP) in the United States.\n                    <jats:bold>Methods:<\/jats:bold>\n                    A retrospective cohort study was performed of patients with RP in the IRIS Registry (2013\u20132023). The association between clinical characteristics and CME was analyzed using multivariate logistic regression.\n                    <jats:bold>Results:<\/jats:bold>\n                    Among 50 219 patients with RP, 8495 (16.9% of eyes) had CME. Patients with CME were slightly younger (median age, 56 years) compared with those without CME (median age, 58 years;\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; .001). Ocular comorbidities and procedures were more common in RP eyes with CME than in those without, including epiretinal membrane (ERM) (39% vs 15%), vitreomacular traction (VMT) (7.5% vs 1.6%), diabetic retinopathy (8% vs 3.9%), retinal vein occlusion (4.8% vs 0.4%), cataract surgery (20% vs 17%), Nd:YAG capsulotomy (11% vs 9%), and pars plana vitrectomy (2.1% vs 0.9%) (all\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; .001). On multivariate analysis, the odds of CME increased with observation time and decreased with age. History of ERM or VMT conferred significantly higher odds of CME (odds ratio [OR], 3.01, 95% CI, 2.85\u20133.18 vs OR, 2.49, 95% CI, 2.18\u20132.84 in those with no ERM or VMT). Eyes undergoing cataract surgery or vitrectomy also had higher CME risk (OR, 1.18, 95% CI, 1.10\u20131.27; OR, 1.66, 95% CI, 1.36\u20132.03). Visual acuity at diagnosis and 2 years later was worse in eyes with CME compared with those without CME (median, 0.3 logMAR vs 0.18 logMAR;\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; .001).\n                    <jats:bold>Conclusions:<\/jats:bold>\n                    CME is a frequent complication in patients with RP and is associated with younger age, longer observation, and coexisting ocular conditions. Careful monitoring of high-risk patients is critical for timely detection and management.\n                  <\/jats:p>","DOI":"10.1177\/24741264261438470","type":"journal-article","created":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T01:28:52Z","timestamp":1778894932000},"page":"970-977","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Prevalence and Risk Factors of Cystoid Macular Edema in Patients With Retinitis Pigmentosa in the United States: IRIS Registry Analysis"],"prefix":"10.1177","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5435-8804","authenticated-orcid":false,"given":"Ahmad","family":"Al-Moujahed","sequence":"first","affiliation":[{"name":"Byers Eye Institute, Department of Ophthalmology, Stanford University, Palo Alto, CA, USA"},{"name":"Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-3946-7844","authenticated-orcid":false,"given":"Eric","family":"Goldberg","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Connor","family":"Ross","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirill","family":"Zaslavsky","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Elze","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Sobrin","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan W.","family":"Miller","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Lorch","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Huckfeldt","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the IRIS Registry Analytic Center Consortium","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,5,15]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.10.4526"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1395-3907.2002.00001.x"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/cge.12203"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1080\/09286586.2017.1383448"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.08-1992"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.12-10149"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.iae.0000250008.83779.23"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2022.895208"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2017.09.009"},{"key":"e_1_3_2_11_2","unstructured":"CenterWatch. 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