{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T18:52:08Z","timestamp":1793213528028,"version":"4.5.0"},"reference-count":14,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,4,26]],"date-time":"2026-04-26T00:00:00Z","timestamp":1777161600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of VitreoRetinal Diseases"],"abstract":"<jats:p>\n                    <jats:bold>Purpose:<\/jats:bold>\n                    To report a case of high-altitude cerebral edema and high-altitude retinopathy resulting in persistent neurologic and long-term visual sequelae following inadequate acclimatization.\n                    <jats:bold>Methods:<\/jats:bold>\n                    A single case was reviewed.\n                    <jats:bold>Results:<\/jats:bold>\n                    A 32-year-old man developed high-altitude sickness during a hike in the Andes, most likely due to inadequate acclimatization during ascent. He was diagnosed with high-altitude cerebral edema and high-altitude retinopathy. Neurologic deficits persisted during the 4-day stay at high altitude but resolved immediately after descent below 4300 m; however, multiple cerebral hemorrhages remained visible on magnetic resonance imaging. Severe bilateral macular hemorrhage led to prolonged vision loss lasting several months. Both eyes subsequently developed macular epiretinal membranes, with a macular hole in the right eye requiring vitrectomy. Although intraretinal hemorrhages in the posterior pole resolved, multifocal electroretinography demonstrated numerous persistent areas of reduced retinal response density for several months.\n                    <jats:bold>Conclusions:<\/jats:bold>\n                    Adequate acclimatization is essential for preventing high-altitude sickness, even in experienced climbers. High-altitude retinopathy may result in permanent vision loss; therefore, long-term ophthalmologic monitoring is recommended.\n                  <\/jats:p>","DOI":"10.1177\/24741264261440754","type":"journal-article","created":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T02:13:53Z","timestamp":1777256033000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["High-Altitude Retinopathy With Bilateral Macular Hemorrhage and Brain Edema"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2342-4776","authenticated-orcid":false,"given":"Hanna","family":"Zaj\u0105c","sequence":"first","affiliation":[{"name":"Ophthalmology Department, University Clinical Hospital in Wroc\u0142aw, Wroc\u0142aw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnieszka","family":"Ga\u0142ka-Zielony","sequence":"additional","affiliation":[{"name":"Neurology Department with Stroke Subdivision, T. Marciniak Lower Silesian Specialist Hospital \u2013 Emergency Medicine Centre, Wroc\u0142aw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Turno-Kr\u0119cicka","sequence":"additional","affiliation":[{"name":"Ophthalmology Department, University Clinical Hospital in Wroc\u0142aw, Wroc\u0142aw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewa","family":"Horoch-\u0141yszczarek","sequence":"additional","affiliation":[{"name":"Neurology Department with Stroke Subdivision, T. Marciniak Lower Silesian Specialist Hospital \u2013 Emergency Medicine Centre, Wroc\u0142aw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,4,26]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/practneurol-2017-001783"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2023.1191058"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-022-00976-3"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmaid.2022.102493"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2022.1041280"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S415695"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.wem.2023.05.013"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12886-020-01563-1"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmaid.2024.102689"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/7076190"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1089\/ham.2013.1086"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.5550"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1159\/000088387"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00245.2013"}],"container-title":["Journal of VitreoRetinal Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/24741264261440754","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/24741264261440754","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/24741264261440754","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T15:24:27Z","timestamp":1790695467000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/24741264261440754"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,26]]},"references-count":14,"alternative-id":["10.1177\/24741264261440754"],"URL":"https:\/\/doi.org\/10.1177\/24741264261440754","relation":{},"ISSN":["2474-1264","2474-1272"],"issn-type":[{"value":"2474-1264","type":"print"},{"value":"2474-1272","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,26]]},"article-number":"24741264261440754"}}