{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,12]],"date-time":"2026-11-12T11:35:07Z","timestamp":1794483307573,"version":"4.9.1"},"reference-count":30,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T00:00:00Z","timestamp":1779148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of VitreoRetinal Diseases"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:p>\n                    <jats:bold>Purpose:<\/jats:bold>\n                    To determine whether systemically administered immunomodulatory therapeutic agents may be associated with a lower risk of reoperation following initially successful repair of rhegmatogenous retinal detachment (RRD).\n                    <jats:bold>Methods:<\/jats:bold>\n                    This was a retrospective cohort study conducted using the IRIS Registry to identify patients who had undergone surgical repair of RRD and had at least 6 months of postoperative follow-up. Patients receiving systemic immunomodulatory therapy for a non-ocular inflammatory disease at the time of repair (group 1) and control subjects not receiving immunomodulatory therapy at the time of repair (group 2) were identified. The main outcome measure was rate of reoperation within 90 days.\n                    <jats:bold>Results:<\/jats:bold>\n                    Group 1 was composed of 683 patients (705 eyes). Group 2 was composed of 36 298 patients (37 337 eyes). The proportion of eyes requiring reoperation was 78\/705 (11.1%) in group 1 and 5119\/37 337 (13.7%) in group 2. The risk of reoperation was higher for group 2, with an odds ratio (OR) of 1.30 (95% CI, 1.01-1.66) compared with group 1 (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = .038). Other risk factors associated with additional surgical intervention in groups 1 and 2 were older age (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = .014 and\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = .011) and positive smoking history (each\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; .001).\n                    <jats:bold>Conclusions:<\/jats:bold>\n                    The need for reoperation following primary RRD repair was lower in patients being treated with systemic immunomodulatory therapy at the time of surgery. Individuals not receiving immunomodulatory therapy were 1.3 times more likely to require reoperation. Additional studies are warranted to assess systemic immunomodulatory therapy as a treatment option for patients at high risk for redetachment due to proliferative vitreoretinopathy.\n                  <\/jats:p>","DOI":"10.1177\/24741264261442922","type":"journal-article","created":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T04:52:02Z","timestamp":1779252722000},"page":"954-963","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Systemic Immunomodulatory Therapy and the Rate of Reoperation for Retinal Redetachment in Adults: An IRIS Registry Study"],"prefix":"10.1177","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6607-5660","authenticated-orcid":false,"given":"Jeanette","family":"Du","sequence":"first","affiliation":[{"name":"Retina Group of Washington, Chevy Chase, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hailey","family":"Robles-Holmes","sequence":"additional","affiliation":[{"name":"Georgetown University School of Medicine, Washington, DC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-7810-8760","authenticated-orcid":false,"given":"Abdullah","family":"Abou-Samra","sequence":"additional","affiliation":[{"name":"Retina Group of Washington, Chevy Chase, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynn","family":"Liu","sequence":"additional","affiliation":[{"name":"American Academy of Ophthalmology, San Francisco, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Li","sequence":"additional","affiliation":[{"name":"American Academy of Ophthalmology, San Francisco, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Melamud","sequence":"additional","affiliation":[{"name":"Retina Group of Washington, Chevy Chase, MD, USA"},{"name":"Georgetown University School of Medicine, Washington, DC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason M.","family":"Huang","sequence":"additional","affiliation":[{"name":"Retina Group of Washington, Chevy Chase, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua D.","family":"Levinson","sequence":"additional","affiliation":[{"name":"Retina Group of Washington, Chevy Chase, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1077-2341","authenticated-orcid":false,"given":"Mohsin H.","family":"Ali","sequence":"additional","affiliation":[{"name":"Retina Group of Washington, Chevy Chase, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1707-6899","authenticated-orcid":false,"given":"Brian K.","family":"Do","sequence":"additional","affiliation":[{"name":"Retina Group of Washington, Chevy Chase, MD, USA"},{"name":"Georgetown University School of Medicine, Washington, DC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,5,19]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0039-6257(98)00023-x"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/IIO.0000000000000258"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0161-6420(87)33443-8"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/s1350-9462(01)00023-4"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/269787"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2012.12.004"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/8959153"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.eye.6702260"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2017.01.021"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2006.08.042"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.3928\/23258160-20220920-04"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-021-05206-z"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.114088"},{"key":"e_1_3_3_15_2","volume-title":"American Academy of Ophthalmology Annual Meeting","author":"Zarbin MA.","unstructured":"Zarbin MA. The phase 3 GUARD trial of ADX-2191 (methotrexate for intravitreal administration) for the prevention of proliferative vitreoretinopathy and other postoperative complications. Paper presented at: American Academy of Ophthalmology Annual Meeting; September 30\u2013October 3, 2022; Chicago, IL."},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0889-857x(05)70358-6"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0000000000000589"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.4103\/ijo.IJO_1548_20"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.16-20912"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.18240\/ijo.2022.09.01"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.119.10.1518"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.oret.2024.10.023"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000001361"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.3109\/02713689409025133"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0271950"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2022.09.009"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.10.060"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41433-022-02061-y"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0292698"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000002969"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00586"}],"container-title":["Journal of VitreoRetinal Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/24741264261442922","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/24741264261442922","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/24741264261442922","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,11,12]],"date-time":"2026-11-12T10:35:33Z","timestamp":1794479733000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/24741264261442922"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,19]]},"references-count":30,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1177\/24741264261442922"],"URL":"https:\/\/doi.org\/10.1177\/24741264261442922","relation":{},"ISSN":["2474-1264","2474-1272"],"issn-type":[{"value":"2474-1264","type":"print"},{"value":"2474-1272","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,19]]}}}