{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:05:41Z","timestamp":1790697941560,"version":"4.1.0"},"reference-count":14,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T00:00:00Z","timestamp":1779148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of VitreoRetinal Diseases"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:p>\n                    <jats:bold>Purpose:<\/jats:bold>\n                    To assess the impact of repeated intravitreal (IVT) antivascular endothelial growth factor (anti-VEGF) injections on the vitreomacular interface in eyes with cystoid macular edema secondary to central retinal vein occlusion (CRVO).\n                    <jats:bold>Methods:<\/jats:bold>\n                    This retrospective cohort study included 45 treatment-na\u00efve eyes with CRVO with 12 or more months of follow-up. The cohort had a mean (\u00b1SD) age of 62 \u00b1 12 years, was 40% male, and was racially diverse (60% White, 29% Black). All eyes received more than 1 anti-VEGF injection. Vitreomacular status was staged at baseline and 12 months using optical coherence tomography. Eyes with complete posterior vitreous detachment (PVD) at presentation or previous treatment for CRVO were excluded. Twenty-seven untreated fellow eyes served as controls.\n                    <jats:bold>Results:<\/jats:bold>\n                    PVD progression occurred in 42% of eyes with CRVO, with 4% reaching complete PVD. The 19 eyes with CRVO that progressed received more injections (mean, 8.4 \u00b1 2.4) than the 26 CRVO nonprogressors (mean, 6.2 \u00b1 2.8;\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = .01). Only 18.5% of fellow eyes progressed. Analysis of paired data from 27 eyes with CRVO and 27 fellow eyes showed greater change in vitreomacular stage from presentation to 12 months in eyes with CRVO vs fellow eyes (mean difference, 0.44;\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = .047).\n                    <jats:bold>Conclusions:<\/jats:bold>\n                    Eyes with CRVO receiving multiple IVT injections showed significantly greater progression toward complete PVD than untreated fellow eyes.\n                  <\/jats:p>","DOI":"10.1177\/24741264261445186","type":"journal-article","created":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T13:56:58Z","timestamp":1779199018000},"page":"672-678","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Effect of Intravitreal Anti-VEGF Injections on the Vitreomacular Interface in Treatment-Na\u00efve Eyes With Central Retinal Vein Occlusion"],"prefix":"10.1177","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-8474-2841","authenticated-orcid":false,"given":"Rachel","family":"D\u2019Cunha","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Duke University School of Medicine, Durham, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Hemesath","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Duke University School of Medicine, Durham, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxi","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Duke University School of Medicine, Durham, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3852-805X","authenticated-orcid":false,"given":"Terry","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Duke University School of Medicine, Durham, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akshay S.","family":"Thomas","sequence":"additional","affiliation":[{"name":"Tennessee Retina, Nashville, TN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinxin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Cape Fear Eye Associates, Fayetteville, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry","family":"Feng","sequence":"additional","affiliation":[{"name":"Illinois Retina Associates, Chicago, IL, USA"},{"name":"Department of Ophthalmology, Rush University Medical Center, Chicago, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Stinnett","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Duke University School of Medicine, Durham, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4403-5996","authenticated-orcid":false,"given":"Sharon","family":"Fekrat","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Duke University School of Medicine, Durham, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,5,19]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2013.07.042"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.optm.2009.07.014"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40942-021-00295-8"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2015.04.028"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-013-2266-y"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.4103\/tjo.tjo_9_17"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12886-022-02682-7"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.119.10.1475"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/aos.14746"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000001228"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/eye.1987.45"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000003932"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1110823"},{"key":"e_1_3_2_15_2","first-page":"1239","article-title":"Resolution of vitreomacular traction following intravitreal triamcinolone acetonide injection in an eye with branch retinal vein occlusion","volume":"6","author":"Seymeno\u011flu G","year":"2012","unstructured":"Seymeno\u011flu G, Kay\u0131k\u00e7\u0131o\u011flu O, Sahin B\u00d6. Resolution of vitreomacular traction following intravitreal triamcinolone acetonide injection in an eye with branch retinal vein occlusion. Clin Ophthalmol. 2012;6:1239-1243.","journal-title":"Clin Ophthalmol"}],"container-title":["Journal of VitreoRetinal Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/24741264261445186","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/24741264261445186","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/24741264261445186","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T15:24:43Z","timestamp":1790695483000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/24741264261445186"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,19]]},"references-count":14,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1177\/24741264261445186"],"URL":"https:\/\/doi.org\/10.1177\/24741264261445186","relation":{},"ISSN":["2474-1264","2474-1272"],"issn-type":[{"value":"2474-1264","type":"print"},{"value":"2474-1272","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,19]]}}}