{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:04:34Z","timestamp":1790697874268,"version":"4.1.0"},"reference-count":44,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:00:00Z","timestamp":1779235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of VitreoRetinal Diseases"],"abstract":"<jats:p>\n                    <jats:bold>Purpose:<\/jats:bold>\n                    To evaluate anatomic and visual outcomes following primary repair of rhegmatogenous retinal detachment (RRD) with adjunctive intraoperative mitomycin C (MMC).\n                    <jats:bold>Methods:<\/jats:bold>\n                    This retrospective, single-center case series included eyes undergoing primary RRD repair with intraoperative MMC between March and December 2020. Eyes with retinal detachment duration &lt;4 weeks and no proliferative vitreoretinopathy at presentation were included. MMC dose (low-medium: 0.002-0.12 mg; high: 0.15-0.2 mg), concentration, and exposure duration were recorded. The primary endpoint was recurrent retinal detachment requiring re-intervention. Secondary endpoints included longitudinal best-corrected visual acuity (BCVA; Early Treatment Diabetic Retinopathy Study [ETDRS] letters) and clinically apparent adverse events.\n                    <jats:bold>Results:<\/jats:bold>\n                    A total of 80 eyes from 78 patients (mean age, 62 years; 73% male) were analyzed. Macula-off retinal detachment was present in 56% of eyes. Redetachment occurred in 3 eyes (3.8%), all in the low-medium dose group. Mean BCVA improved from 38 to 66 ETDRS letters (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; .001), with no significant dose-dependent effect (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = .704). No clinically apparent hypotony, anterior segment ischemia, or retinal toxicity attributable to MMC was observed during follow-up.\n                    <jats:bold>Conclusions:<\/jats:bold>\n                    In this pilot series of primary RRD without proliferative vitreoretinopathy, intraoperative MMC was not associated with clinically apparent toxicity and demonstrated favorable short-term anatomic and visual outcomes. Prospective controlled studies are warranted to confirm these findings.\n                  <\/jats:p>","DOI":"10.1177\/24741264261445237","type":"journal-article","created":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T11:38:31Z","timestamp":1779277111000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Outcomes of Primary Rhegmatogenous Retinal Detachment Repair With Adjunctive Mitomycin C"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4448-2104","authenticated-orcid":false,"given":"Abdulla","family":"Shaheen","sequence":"first","affiliation":[{"name":"Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumit P.","family":"Bhatia","sequence":"additional","affiliation":[{"name":"Signature Retina Consultants, Normal, Illinois, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,5,20]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e31820d3f55"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(95)30932-3"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.18240\/ijo.2016.11.15"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40662-022-00325-y"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000002715"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.4103\/ijo.IJO_1212_18"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/810609"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11154551"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2018-312839"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S80983"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e3182923463"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.3928\/23258160-20230220-01"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjophth-2019-000293"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-386454-3.00883-6"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD002897.pub2"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.84.7.714"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1991.01080120077030"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.18240\/ijo.2016.03.25"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2415-4-12"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2003.039891"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1517\/14740338.6.1.27"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2009.04.002"},{"key":"e_1_3_3_24_2","first-page":"3","article-title":"The potential role of mitomycin C in the management of proliferative vitreoretinopathy","volume":"1","author":"Soliman M","year":"2005","unstructured":"Soliman M, Macky T, Ali KG. 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