{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:06:36Z","timestamp":1790697996915,"version":"4.1.0"},"reference-count":14,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T00:00:00Z","timestamp":1783641600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100001818","name":"Research to Prevent Blindness","doi-asserted-by":"publisher","award":["GR004596-1"],"award-info":[{"award-number":["GR004596-1"]}],"id":[{"id":"10.13039\/100001818","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of VitreoRetinal Diseases"],"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To describe the clinical features, antimicrobial susceptibilities, and treatment outcomes of acute-onset exogenous Nocardia endophthalmitis following non-cataract surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Two cases were retrospectively reviewed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Two patients developed acute-onset exogenous endophthalmitis following non-cataract procedures and subsequently underwent multiple surgical interventions. The first patient developed a fulminant infection in the left eye following revision of a glaucoma drainage implant and ultimately progressed to no-light-perception vision, undergoing enucleation. The second patient developed endophthalmitis secondary to infectious scleritis in the right eye and had a best-corrected visual acuity of 5\/200 at last follow-up. Microbiologic analysis identified\n                      <jats:italic toggle=\"yes\">Nocardia brasiliensis<\/jats:italic>\n                      and\n                      <jats:italic toggle=\"yes\">Nocardia niwae.<\/jats:italic>\n                      Both isolates demonstrated susceptibility to amikacin and sulfamethoxazole\/trimethoprim, with variable susceptibility to \u03b2-lactams and fluoroquinolones.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Acute-onset exogenous Nocardia endophthalmitis may occur after a variety of ophthalmologic procedures and is associated with a poor visual prognosis despite surgical intervention and targeted antimicrobial therapy. Amikacin and sulfamethoxazole\/trimethoprim remain the preferred antimicrobial agents.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/24741264261467248","type":"journal-article","created":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T07:28:56Z","timestamp":1783668536000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Features, Antimicrobial Susceptibilities, and Outcomes of Acute-Onset Exogenous Nocardia Endophthalmitis"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-2145-8202","authenticated-orcid":false,"given":"Michael Y.","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Health System, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6468-784X","authenticated-orcid":false,"given":"Zhuochen","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Health System, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin Kyun","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Health System, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darlene","family":"Miller","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Health System, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9990-7467","authenticated-orcid":false,"suffix":"Jr.","given":"Harry W.","family":"Flynn","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Health System, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,7,10]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2018.09.007"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2010.10.037"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2004.12.005"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/ICB.0000000000001840"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2017.4276"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0002-9394(02)02294-8"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2018.10.023"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph18147602"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2020-316846"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-019-04261-x"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1080\/09273948.2020.1826536"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.4103\/ijo.IJO_564_16"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.5c02351"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1994.01090220113032"}],"container-title":["Journal of VitreoRetinal Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/24741264261467248","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/24741264261467248","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/24741264261467248","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T15:26:37Z","timestamp":1790695597000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/24741264261467248"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,10]]},"references-count":14,"alternative-id":["10.1177\/24741264261467248"],"URL":"https:\/\/doi.org\/10.1177\/24741264261467248","relation":{},"ISSN":["2474-1264","2474-1272"],"issn-type":[{"value":"2474-1264","type":"print"},{"value":"2474-1272","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,10]]},"article-number":"24741264261467248"}}