{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:04:43Z","timestamp":1790697883824,"version":"4.1.0"},"reference-count":9,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:00:00Z","timestamp":1783468800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:00:00Z","timestamp":1783468800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of VitreoRetinal Diseases"],"abstract":"\n Purpose:<\/jats:title>\n To describe the clinical evolution of adenocarcinoma arising from unilateral retinal pigment epithelium (RPE) dysgenesis.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n A single case was reviewed.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n A young patient with no relevant family history was referred for evaluation of a fundus lesion of the left eye that had progressed after 5 years of stability. Examination and multimodal imaging revealed a smooth, dome-shaped, amelanotic mass in the posterior pole with overlying vascular distortion and internal calcification. Due to the poor visual prognosis, diagnostic enucleation was performed. Histopathologic analysis revealed a well-differentiated epithelial tumor arising from the RPE. Immunohistochemistry was positive for vimentin and neuron-specific enolase and weakly positive for HMB-45 and MART-1, while electron microscopy demonstrated intercellular basal lamina and desmosome-like junctions, confirming RPE differentiation.<\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n This case illustrates confirmed adenocarcinoma arising from unilateral RPE dysgenesis and supports the role of surveillance for some RPE lesions in which malignant transformation may occur as a rare event.<\/jats:p>\n <\/jats:sec>","DOI":"10.1177\/24741264261467263","type":"journal-article","created":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T12:12:31Z","timestamp":1783512751000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Adenocarcinoma Arising from Unilateral Retinal Pigment Epithelium Dysgenesis"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7069-3162","authenticated-orcid":false,"given":"Brendan K.","family":"Tao","sequence":"first","affiliation":[{"name":"Department of Ophthalmology & Vision Sciences, University of Toronto, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2692-0759","authenticated-orcid":false,"given":"Andrew","family":"Mihalache","sequence":"additional","affiliation":[{"name":"Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filiberto","family":"Altomare","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology & Vision Sciences, University of Toronto, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zelia M.","family":"Correa","sequence":"additional","affiliation":[{"name":"Bascom Palmer Eye Institute and Sylvester Comprehensive Cancer Center, University of Miami, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo V.","family":"Navajas","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, BC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,7,8]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.oret.2020.03.008"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.119.4.597"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1159\/000509484"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/ICB.0000000000001785"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2009.06.033"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-005-0011-x"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.126.5.670"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/ICB.0000000000000568"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/ICB.0000000000000859"}],"container-title":["Journal of VitreoRetinal Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/24741264261467263","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/24741264261467263","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/24741264261467263","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T15:26:36Z","timestamp":1790695596000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/24741264261467263"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,8]]},"references-count":9,"alternative-id":["10.1177\/24741264261467263"],"URL":"https:\/\/doi.org\/10.1177\/24741264261467263","relation":{},"ISSN":["2474-1264","2474-1272"],"issn-type":[{"value":"2474-1264","type":"print"},{"value":"2474-1272","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,8]]},"article-number":"24741264261467263"}}