{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:05:56Z","timestamp":1790697956641,"version":"4.1.0"},"reference-count":28,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T00:00:00Z","timestamp":1785974400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"J.Arch McNamara, MD Fund for Retina Research and Education"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of VitreoRetinal Diseases"],"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To determine whether a topical rho-kinase inhibitor used in eyes with primary rhegmatogenous retinal detachment (RRD) at high risk for proliferative vitreoretinopathy (PVR) reduces the rate of recurrent RD due to grade C or worse PVR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This randomized, double-masked, placebo-controlled trial (ClinicalTrials.gov: NCT05660447) included patients with primary RRD undergoing pars plana vitrectomy (PPV), with or without scleral buckling, who had 1 to 3 PVR risk factors: 3 or more breaks, 2 or more quadrants of RD, RD for longer than 3 weeks, vitreous hemorrhage, or choroidal detachment. Participants were randomized to netarsudil 0.02% or artificial tears, administered once daily for 8 weeks starting on postoperative day 1. The primary outcome was the rate of recurrent RD due to grade C PVR at 6 months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      A total of 79 patients were randomized (40 to netarsudil, 39 to placebo). After excluding dropouts and those lost to follow-up, 38 netarsudil and 34 placebo participants were analyzed. There was no significant difference in baseline high-risk features for PVR between the netarsudil and placebo arms. Eight eyes (21.1%) in the netarsudil arm vs 6 eyes (17.6%) in the placebo arm developed redetachment (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .77), with 4 vs 6 of the redetachments due to PVR (10.5% vs 17.6%;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .5). At 6 months, epiretinal membrane was found in 55.2% of eyes in the netarsudil group and in 63.6% in the placebo group (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &gt; .99). Median logMAR (Snellen equivalent) visual acuity in the netarsudil vs placebo arm was 1.24 (20\/350) vs 1.35 (20\/450) at baseline (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .87), 0.7 (20\/100) vs 0.48 (20\/60) at month 3 (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .27), and 0.48 (20\/60) vs 0.54 (20\/70) at month 6 (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .91).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Treatment of eyes with primary RRD at high risk for PVR with netarsudil 0.02% once daily for 8 weeks after PPV with or without scleral buckling did not appear to affect PVR redetachment or visual outcomes compared with placebo.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/24741264261469002","type":"journal-article","created":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T08:19:56Z","timestamp":1786004396000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Pilot Clinical Trial of Topical Netarsudil to Lower Risk of Proliferative Vitreoretinopathy in High-Risk Primary Retinal Detachment"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5435-7369","authenticated-orcid":false,"given":"Bita","family":"Momenaei","sequence":"first","affiliation":[{"name":"The Retina Service of Wills Eye Hospital, Wills Eye Physicians-Mid Atlantic Retina, Thomas Jefferson University, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-6062-4894","authenticated-orcid":false,"given":"Roselind","family":"Ni","sequence":"additional","affiliation":[{"name":"The Retina Service of Wills Eye Hospital, Wills Eye Physicians-Mid Atlantic Retina, Thomas Jefferson University, Philadelphia, PA, USA"},{"name":"Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingwen","family":"Zhang","sequence":"additional","affiliation":[{"name":"The Retina Service of Wills Eye Hospital, Wills Eye Physicians-Mid Atlantic Retina, Thomas Jefferson University, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6847-7169","authenticated-orcid":false,"given":"Yoshihiro","family":"Yonekawa","sequence":"additional","affiliation":[{"name":"The Retina Service of Wills Eye Hospital, Wills Eye Physicians-Mid Atlantic Retina, Thomas Jefferson University, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajay E.","family":"Kuriyan","sequence":"additional","affiliation":[{"name":"The Retina Service of Wills Eye Hospital, Wills Eye Physicians-Mid Atlantic Retina, Thomas Jefferson University, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meera D.","family":"Sivalingam","sequence":"additional","affiliation":[{"name":"The Retina Service of Wills Eye Hospital, Wills Eye Physicians-Mid Atlantic Retina, Thomas Jefferson University, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordan D.","family":"Deaner","sequence":"additional","affiliation":[{"name":"The Retina Service of Wills Eye Hospital, Wills Eye Physicians-Mid Atlantic Retina, Thomas Jefferson University, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anton","family":"Orlin","sequence":"additional","affiliation":[{"name":"The Retina Service of Wills Eye Hospital, Wills Eye Physicians-Mid Atlantic Retina, Thomas Jefferson University, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael N.","family":"Cohen","sequence":"additional","affiliation":[{"name":"The Retina Service of Wills Eye Hospital, Wills Eye Physicians-Mid Atlantic Retina, Thomas Jefferson University, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A.","family":"Klufas","sequence":"additional","affiliation":[{"name":"The Retina Service of Wills Eye Hospital, Wills Eye Physicians-Mid Atlantic Retina, Thomas Jefferson University, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunir J.","family":"Garg","sequence":"additional","affiliation":[{"name":"The Retina Service of Wills Eye Hospital, Wills Eye Physicians-Mid Atlantic Retina, Thomas Jefferson University, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allen C.","family":"Ho","sequence":"additional","affiliation":[{"name":"The Retina Service of Wills Eye Hospital, Wills Eye Physicians-Mid Atlantic Retina, Thomas Jefferson University, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Xu","sequence":"additional","affiliation":[{"name":"The Retina Service of Wills Eye Hospital, Wills Eye Physicians-Mid Atlantic Retina, Thomas Jefferson University, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James F.","family":"Vander","sequence":"additional","affiliation":[{"name":"The Retina Service of Wills Eye Hospital, Wills Eye Physicians-Mid Atlantic Retina, Thomas Jefferson University, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allen","family":"Chiang","sequence":"additional","affiliation":[{"name":"The Retina Service of Wills Eye Hospital, Wills Eye Physicians-Mid Atlantic Retina, Thomas Jefferson University, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard S.","family":"Kaiser","sequence":"additional","affiliation":[{"name":"The Retina Service of Wills Eye Hospital, Wills Eye Physicians-Mid Atlantic Retina, Thomas Jefferson University, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2761-4219","authenticated-orcid":false,"given":"Jason","family":"Hsu","sequence":"additional","affiliation":[{"name":"The Retina Service of Wills Eye Hospital, Wills Eye Physicians-Mid Atlantic Retina, Thomas Jefferson University, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,8,6]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6257(98)00023-8"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0292698"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000004391"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000000341"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.17-21885"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-011-1919-y"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2006.08.042"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1442-9071.2002.00554.x"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2015.09.030"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/ICU.0000000000000652"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2015.1006"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.03-0451"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2006.10.014"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.3980\/j.issn.2222-3959.2013.01.02"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1167\/tvst.6.3.22"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.oret.2023.05.017"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.oret.2020.03.017"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000000216"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-014-2610-x"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.oret.2020.06.021"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40942-022-00413-z"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2005.01.051"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-021-05118-y"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2021.07.019"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41433-024-03125-5"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1089\/jop.2017.0027"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2020.03.006"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000003608"}],"container-title":["Journal of VitreoRetinal Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/24741264261469002","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/24741264261469002","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/24741264261469002","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T15:24:32Z","timestamp":1790695472000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/24741264261469002"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,6]]},"references-count":28,"alternative-id":["10.1177\/24741264261469002"],"URL":"https:\/\/doi.org\/10.1177\/24741264261469002","relation":{},"ISSN":["2474-1264","2474-1272"],"issn-type":[{"value":"2474-1264","type":"print"},{"value":"2474-1272","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,6]]},"article-number":"24741264261469002"}}