{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T14:52:30Z","timestamp":1791039150225,"version":"4.1.0"},"reference-count":24,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of VitreoRetinal Diseases"],"abstract":"<jats:p>\n                    <jats:bold>Purpose:<\/jats:bold>\n                    To describe the clinical, anatomic, functional, and therapeutic characteristics of patients with retinal vasoproliferative tumors in real-world clinical practice, comparing the clinical features of primary and secondary tumors.\n                    <jats:bold>Methods:<\/jats:bold>\n                    A multicenter, retrospective, longitudinal case series study was conducted, including cases of retinal vasoproliferative tumors at 3 ophthalmology referral centers in Chile between 2006 and 2026. A total of 24 eyes from 23 patients with a clinical diagnosis of retinal vasoproliferative tumor were included. Demographic, topographic, biometric, functional, and treatment variables were analyzed. Parametric and nonparametric tests were used.\n                    <jats:bold>Results:<\/jats:bold>\n                    The mean age was 45.6 \u00b1 15.2 years; 70.8% were primary tumors, and 29.2% were secondary. Most cases were unilateral (91.7%) and active at diagnosis (79.2%), with a predominance in the inferior and inferotemporal quadrants. The mean baseline best-corrected visual acuity was 0.75 \u00b1 0.64 logMAR, and the final best-corrected visual acuity was 0.60 \u00b1 0.79 logMAR, with no statistically significant overall functional improvement (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = .27). Laser photocoagulation, the most performed treatment, was done in 54.2%. A favorable anatomic response was achieved in 91.7% of eyes. Retreatment was more frequent in secondary than in primary tumors (85.7% vs 35.3%; absolute risk difference, +50.4%; odds ratio, 11.0; 95% CI, 1.06-114.1; Fisher exact\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = .069).\n                    <jats:bold>Conclusions:<\/jats:bold>\n                    Retinal vasoproliferative tumors achieved a high rate of anatomic control with currently used therapies; however, functional recovery was limited. Secondary tumors showed a clinically important but statistically imprecise trend toward greater retreatment need; this finding should be regarded as hypothesis-generating and warrants close follow-up.\n                  <\/jats:p>","DOI":"10.1177\/24741264261484834","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:53:19Z","timestamp":1790776399000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Retinal Vasoproliferative Tumors in Real-World Practice"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1326-8511","authenticated-orcid":false,"given":"Piero","family":"Barrera-Arshavin","sequence":"first","affiliation":[{"name":"Fundaci\u00f3n Oftalmol\u00f3gica Los Andes, Universidad de los Andes, Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Crist\u00f3bal","family":"Orme\u00f1o-Illanes","sequence":"additional","affiliation":[{"name":"Retina Department, Ophthalmology Service, Hospital Regional Dr. Guillermo Grant Benavente, Concepci\u00f3n, Chile"},{"name":"Retina Department, Ophthalmology Service, Hospital Las Higueras, Talcahuano, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camilo","family":"Urz\u00faa-\u00c1lvarez","sequence":"additional","affiliation":[{"name":"Retina Department, Ophthalmology Service, Hospital Regional Dr. Guillermo Grant Benavente, Concepci\u00f3n, Chile"},{"name":"Retina Department, Ophthalmology Service, Hospital Las Higueras, Talcahuano, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo","family":"Az\u00f3car-Barrera","sequence":"additional","affiliation":[{"name":"Retina Department, Ophthalmology Service, Hospital Regional Dr. Guillermo Grant Benavente, Concepci\u00f3n, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Caselli-Morgado","sequence":"additional","affiliation":[{"name":"Retina Department, Ophthalmology Service, Hospital Regional Dr. Guillermo Grant Benavente, Concepci\u00f3n, Chile"},{"name":"Retina Department, Ophthalmology Service, Hospital Las Higueras, Talcahuano, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfredo","family":"Rojas-Torres","sequence":"additional","affiliation":[{"name":"Retina Department, Ophthalmology Service, Hospital Las Higueras, Talcahuano, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1lvaro","family":"Bofill Ram\u00edrez","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n Oftalmol\u00f3gica Los Andes, Universidad de los Andes, Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4104-0968","authenticated-orcid":false,"given":"Jos\u00e9 Manuel","family":"L\u00f3pez-Astaburuaga","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n Oftalmol\u00f3gica Los Andes, Universidad de los Andes, Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Zachar\u00edas-Santamar\u00eda","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n Oftalmol\u00f3gica Los Andes, Universidad de los Andes, Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3728-0830","authenticated-orcid":false,"given":"Efra\u00edn","family":"P\u00e9rez Argando\u00f1a","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n Oftalmol\u00f3gica Los Andes, Universidad de los Andes, Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Orellana-R\u00edos","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n Oftalmol\u00f3gica Los Andes, Universidad de los Andes, Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Filsecker-L\u00f3pez","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n Oftalmol\u00f3gica Los Andes, Universidad de los Andes, Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Ignacio","family":"Verdaguer-D\u00edaz","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n Oftalmol\u00f3gica Los Andes, Universidad de los Andes, Santiago, Chile"},{"name":"Department of Ophthalmology, Universidad de los Andes, Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,9,30]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.eye.6700311"},{"issue":"1","key":"e_1_3_2_3_2","first-page":"14","article-title":"Vasoproliferative tumors of the retina: pathophysiology, clinical features, and treatment approaches","volume":"12","author":"Lee SM","year":"2026","unstructured":"Lee SM, Choi YJ, Chun J, Yang JM, Kim M. 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