{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:04:52Z","timestamp":1790697892808,"version":"4.1.0"},"reference-count":20,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:00:00Z","timestamp":1789603200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of VitreoRetinal Diseases"],"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To report an unusual presentation of previously undiagnosed tuberous sclerosis complex manifesting as unilateral fibrovascular vitreoretinal proliferation associated with retinal astrocytic hamartoma complicated by vitreous hemorrhage (VH).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A single case was reviewed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      A 29-year-old woman presented with visual loss in the left eye and longstanding reduced vision since childhood. Examination revealed a retinal astrocytic hamartoma in the right eye and VH, fibrovascular vitreoretinal proliferation, retinal disorganization, and macular thickening in the left eye. Fluorescein angiography demonstrated telangiectatic vessels and late-phase leakage. The presence of accompanying cutaneous lesions prompted multidisciplinary evaluation, which revealed systemic tuberous sclerosis complex associated with a heterozygous\n                      <jats:italic toggle=\"yes\">TSC1<\/jats:italic>\n                      mutation. Following a single intravitreal injection of bevacizumab, regression of the VH and stabilization of the proliferative retinal findings were observed during 1 year of follow-up.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Retinal astrocytic hamartomas associated with tuberous sclerosis complex are generally benign and asymptomatic; however, rare progressive forms may present with fibrovascular vitreoretinal proliferative complications. Ocular manifestations may play a critical role in diagnosing previously unrecognized tuberous sclerosis complex.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/24741264261486753","type":"journal-article","created":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T09:16:21Z","timestamp":1789636581000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Unilateral Fibrovascular Vitreoretinal Proliferation Associated With Retinal Astrocytic Hamartoma Revealing Tuberous Sclerosis Complex in Adulthood"],"prefix":"10.1177","author":[{"given":"Efe Polat","family":"\u00d6zkan","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Ankara Etlik City Hospital, Ankara, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gamze","family":"Ta\u015f Aygar","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Ankara Etlik City Hospital, Ankara, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9243-6124","authenticated-orcid":false,"given":"P\u0131nar","family":"\u00c7i\u00e7ek Kaya","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Ankara Etlik City Hospital, Ankara, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berrak","family":"\u015eekeryapan Gediz","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Ankara Etlik City Hospital, Ankara, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,9,17]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.3928\/19382359-20170320-01"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)61279-9"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2021.07.011"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2012.03.020"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.85.4.420"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/aos.15812"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.aopr.2022.09.001"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12886-018-0991-z"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000000829"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1159\/000088377"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2012.124"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.4103\/ijo.IJO_925_18"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.2008.01331.x"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.4103\/IJO.IJO_3418_22"},{"key":"e_1_3_3_16_2","first-page":"139","article-title":"Aggressive retinal astrocytomas in four patients with tuberous sclerosis complex","volume":"102","author":"Shields JA","year":"2004","unstructured":"Shields JA, Eagle RCJr, Shields CL, Marr BP. 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