{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:05:58Z","timestamp":1790697958727,"version":"4.1.0"},"reference-count":14,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of VitreoRetinal Diseases"],"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To describe the management and clinical outcome of severe infectious endophthalmitis after intravitreal (IVT) topotecan injection for retinoblastoma in an eye with potential vision.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A single case was reviewed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      An 8-month-old child with bilateral retinoblastoma receiving systemic chemotherapy developed acute endophthalmitis in the only eye with potential vision 3 days after the sixth IVT topotecan injection. Urgent 23-gauge pars plana vitrectomy was performed to clear dense vitritis and maintain oncologic control using a closed-system approach, melphalan irrigation (5 \u00b5g\/mL), IVT topotecan, port-site cryotherapy, and silicone oil tamponade. The patient also received IVT vancomycin, ceftazidime, and voriconazole. Vitreous culture identified\n                      <jats:italic toggle=\"yes\">Haemophilus influenzae<\/jats:italic>\n                      . The infection resolved, the tumor continued to regress, and no extraocular tumor spread was observed during 24 months of follow-up.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Early, tailored vitrectomy may help preserve vision in severe endophthalmitis after IVT chemotherapy for retinoblastoma when strict oncologic precautions are maintained, with long-term follow-up required to monitor for tumor recurrence or extraocular spread.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/24741264261486768","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T09:54:33Z","timestamp":1789552473000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Culture-Proven\n                    <i>Haemophilus influenzae<\/i>\n                    Endophthalmitis After Intravitreal Topotecan for Retinoblastoma"],"prefix":"10.1177","author":[{"given":"Renu P.","family":"Rajan","sequence":"first","affiliation":[{"name":"Department of Retina &amp; Vitreous Services, Aravind Eye Hospital, Madurai, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muthukrishnan","family":"V","sequence":"additional","affiliation":[{"name":"Department of Retina &amp; Vitreous Services, Aravind Eye Hospital, Madurai, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Usha","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Ocular Oncology, Aravind Eye Hospital, Madurai, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naresh B.","family":"Kannan","sequence":"additional","affiliation":[{"name":"Department of Retina &amp; Vitreous Services, Aravind Eye Hospital, Madurai, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim","family":"Ramasamy","sequence":"additional","affiliation":[{"name":"Department of Retina &amp; Vitreous Services, Aravind Eye Hospital, Madurai, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3929-4523","authenticated-orcid":false,"given":"Arpit","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Retina &amp; Vitreous Services, Aravind Eye Hospital, Madurai, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,9,16]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2011-301450"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000000903"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2004.05.018"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1080\/09273948.2020.1767794"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.5301\/ejo.5000683"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1177\/15330338211048634"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/mbo3.1097"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.5005\/jp\/books\/11629_9"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12348-019-0187-6"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.2011.02158.x"},{"key":"e_1_3_2_12_2","unstructured":"Committee on Infectious Diseases American Academy of Pediatrics. Red Book: 2024\u20132027 report of the Committee on Infectious Diseases. American Academy of Pediatrics; May 14 2024."},{"issue":"6","key":"e_1_3_2_13_2","first-page":"606","article-title":"Endophthalmitis associated with Haemophilus influenzae type B bacteremia and meningitis","volume":"133","author":"Sastry RV","year":"1979","unstructured":"Sastry RV, Baker CJ. Endophthalmitis associated with Haemophilus influenzae type B bacteremia and meningitis. AMA Am J Dis Child. 1979;133(6):606-608.","journal-title":"AMA Am J Dis Child"},{"key":"e_1_3_2_14_2","first-page":"7","article-title":"Pediatric endogenous Haemophilus influenzae endophthalmitis with presumed hyposplenism","volume":"10","author":"Haruta M","year":"2017","unstructured":"Haruta M, Yoshida Y, Yamakawa R. Pediatric endogenous Haemophilus influenzae endophthalmitis with presumed hyposplenism. Int Med Case Rep J. 2017;10:7-9.","journal-title":"Int Med Case Rep J"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S120653"}],"container-title":["Journal of VitreoRetinal Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/24741264261486768","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/24741264261486768","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/24741264261486768","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T15:24:48Z","timestamp":1790695488000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/24741264261486768"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,16]]},"references-count":14,"alternative-id":["10.1177\/24741264261486768"],"URL":"https:\/\/doi.org\/10.1177\/24741264261486768","relation":{},"ISSN":["2474-1264","2474-1272"],"issn-type":[{"value":"2474-1264","type":"print"},{"value":"2474-1272","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,16]]},"article-number":"24741264261486768"}}