{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T14:44:09Z","timestamp":1792161849014,"version":"4.4.0"},"reference-count":14,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of VitreoRetinal Diseases"],"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To characterize changes in fibrovascular membrane traction following antivascular endothelial growth factor (anti-VEGF) treatment in eyes with proliferative diabetic retinopathy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Fibrovascular membrane traction was decomposed into anteroposterior, tangential, and bridging vectors and quantitatively assessed using standardized ultrawide-field fundus imaging with navigated swept-source optical coherence tomography (OCT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Five eyes of 5 patients with high-risk proliferative diabetic retinopathy demonstrated progression of fibrovascular membrane traction following intravitreal anti-VEGF injection. Ultrawide-field fundus imaging with navigated swept-source OCT showed increases in anteroposterior traction ranging from 5.3% to 62% and in tangential traction ranging from 3% to 14% compared with pre-injection measurements (follow-up interval, 1\u201310 weeks). Over a 6-month follow-up period, fibrovascular membrane traction remained stable in 4 eyes, whereas 1 eye developed macula-threatening traction and vision loss requiring vitrectomy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>This retrospective series demonstrates dynamic changes in fibrovascular membrane traction following anti-VEGF therapy in proliferative diabetic retinopathy. Quantitative assessment using integrated ultra-widefield imaging and navigated swept-source OCT may provide a useful approach for monitoring tractional changes and informing clinical decision-making regarding fibrovascular membrane management. Larger prospective studies are warranted to validate these findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/24741264261490794","type":"journal-article","created":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T14:47:15Z","timestamp":1791989235000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Quantitative Analysis of Fibrovascular Membrane Traction in Antivascular Endothelial Growth Factor\u2013Associated Crunch Syndrome Using Integrated Ultrawide-Field Imaging and Swept-Source Optical Coherence Tomography"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6208-2801","authenticated-orcid":false,"given":"Yafeng","family":"Li","sequence":"first","affiliation":[{"name":"Division of Ophthalmology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA"},{"name":"Beetham Eye Institute, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Assel","family":"Talaspayeva","sequence":"additional","affiliation":[{"name":"Beetham Eye Institute, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samet","family":"Gulkas","sequence":"additional","affiliation":[{"name":"Beetham Eye Institute, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Ashraf","sequence":"additional","affiliation":[{"name":"Beetham Eye Institute, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,10,14]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0002-9394(14)75794-0"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199412013312203"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199908263410907"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2006.05.064"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.15217"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-008-0914-4"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/ICB.0b013e3181578dd8"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2011.05.015"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2021.03.001"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/372564"},{"key":"e_1_3_4_12_2","volume-title":"Kanski\u2019s Clinical Ophthalmology: A Systematic Approach","author":"Bowling B","year":"2016","unstructured":"Bowling B, Kanski JJ. 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