{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T18:53:54Z","timestamp":1768071234629,"version":"3.49.0"},"reference-count":39,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T00:00:00Z","timestamp":1464739200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Psoriasis and Psoriatic Arthritis"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p> The risk for cardiovascular events associated with systemic therapies for psoriasis, including biologics, is unclear. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p> We used administrative data from Medicare 2006 through 2011 to identify psoriasis patients who initiated systemic treatments. We estimated incidence rates of hospitalized myocardial infarction, stroke, and a composite cardiovascular disease outcome, adjusting for potentially confounding factors. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> There were 28,878 initiations of psoriasis treatments. Rates of myocardial infarction were highest for methotrexate (10.32\/1000 patient-years, 95%CI 8.55\u201312.46) and numerically lower for biologics. Patterns were similar for stroke and the composite cardiovascular disease outcome. After multivariable adjustment, there were no significant differences between systemic therapies for any of the outcomes studied. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p> In this cohort of predominantly older psoriasis patients, there was neither an elevated nor a protective effect on cardiovascular or stroke events associated with systemic therapies for psoriasis compared to conventional treatments. <\/jats:p><\/jats:sec>","DOI":"10.1177\/247553031600100307","type":"journal-article","created":{"date-parts":[[2018,1,25]],"date-time":"2018-01-25T14:00:34Z","timestamp":1516888834000},"page":"128-137","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Risk of Cardiovascular Outcomes among Psoriasis Patients Treated with Biologics and Other Systemic Agents"],"prefix":"10.1177","volume":"1","author":[{"given":"Jeffrey R.","family":"Curtis","sequence":"first","affiliation":[{"name":"University of Alabama at Birmingham, Division of Clinical Immunology and Rheumatology"},{"name":"University of Alabama at Birmingham, Department of Epidemiology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria I.","family":"Danila","sequence":"additional","affiliation":[{"name":"University of Alabama at Birmingham, Division of Clinical Immunology and Rheumatology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lang","family":"Chen","sequence":"additional","affiliation":[{"name":"University of Alabama at Birmingham, Division of Clinical Immunology and Rheumatology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"Chan","sequence":"additional","affiliation":[{"name":"Oregon Health and Science University, Department of Emergency Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ben","family":"Ehst","sequence":"additional","affiliation":[{"name":"Oregon Health and Science University, Department of Dermatology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fenglong","family":"Xie","sequence":"additional","affiliation":[{"name":"University of Alabama at Birmingham, Division of Clinical Immunology and Rheumatology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin L.","family":"Winthrop","sequence":"additional","affiliation":[{"name":"Divisions of Infectious Diseases, Ophthalmology, and Public Health and Preventive Medicine, Oregon Health and Science University"},{"name":"Center for Health Systems Effectiveness, Oregon Health and Science University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huifeng","family":"Yun","sequence":"additional","affiliation":[{"name":"University of Alabama at Birmingham, Division of Clinical Immunology 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