{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T01:56:11Z","timestamp":1777859771154,"version":"3.51.4"},"reference-count":26,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2022,4,19]],"date-time":"2022-04-19T00:00:00Z","timestamp":1650326400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Psoriasis and Psoriatic Arthritis"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:p>Background: How psoriasis disease characteristics, management, and outcomes each vary across the US is not fully understood. Objective: Assess regional disease characteristics for patients enrolled in CorEvitas Psoriasis Registry, report biologic initiations by class over the period, and evaluate regional outcome data for initiations with 6-month follow-up. Methods: Participants included new biologic initiations in CorEvitas Psoriasis Registry from 2014-2019 categorized into 7 different geographic regions: Northeast, East North Central, Mountain\/West North Central, South Atlantic, East South Central, West South Central, and Pacific. Baseline demographics and disease characteristics are described by region. For participants with 6-month follow-up data, we report treatment patterns and treatment outcomes. Results: 7520 biologic initiations from 6320 patients were available. Over time, biologic initiations in most US regions within the Registry resulted in a pattern where IL-17 inhibitors were used most frequently, followed by IL-12\/23 and IL-23 inhibitors, and lastly by TNF inhibitors. Baseline disease severity varied among regions with the East South Central reporting the largest proportion (25.1%) of very severe disease by body surface area. Frequencies of metabolic comorbid diseases varied between regions (obesity, diabetes, hyperlipidemia, each P &lt; .001; hypertension P &lt; .019), with the East South Central reporting the largest proportions. Rates of achieving PASI75 and IGA 0\/1 varied at 6-months (P = .008 and P = .001, respectively), with the East South Central reporting the lowest frequencies. At 6-months 28.2% of biologic initiations in the East South Central were discontinued, of which 22% had switched to another therapy. Conclusion: Providers should be aware of regional trends in disease characteristics to improve overall care of psoriasis patients.<\/jats:p>","DOI":"10.1177\/24755303221081799","type":"journal-article","created":{"date-parts":[[2022,4,19]],"date-time":"2022-04-19T11:06:23Z","timestamp":1650366383000},"page":"122-131","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Geographic Patterns in Psoriasis: An Observational Study of CorEvitas Psoriasis Registry"],"prefix":"10.1177","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6783-1904","authenticated-orcid":false,"given":"Clinton W.","family":"Enos","sequence":"first","affiliation":[{"name":"Department of Dermatology, Eastern Virginia Medical School, Norfolk, VA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4999-0458","authenticated-orcid":false,"given":"Katie A.","family":"O\u2019Connell","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Eastern Virginia Medical School, Norfolk, VA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan W.","family":"Harrison","sequence":"additional","affiliation":[{"name":"CorEvitas, LLC, Waltham, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert R.","family":"McLean","sequence":"additional","affiliation":[{"name":"CorEvitas, LLC, Waltham, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Blessing","family":"Dube","sequence":"additional","affiliation":[{"name":"CorEvitas, LLC, Waltham, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abby S.","family":"Van Voorhees","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Eastern Virginia Medical School, Norfolk, VA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,4,19]]},"reference":[{"key":"bibr1-24755303221081799","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2013.11.013"},{"key":"bibr2-24755303221081799","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2018.11.057"},{"key":"bibr3-24755303221081799","doi-asserted-by":"publisher","DOI":"10.1016\/j.amepre.2010.12.019"},{"key":"bibr4-24755303221081799","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.55.5.673"},{"key":"bibr5-24755303221081799","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.10.012"},{"key":"bibr6-24755303221081799","doi-asserted-by":"publisher","DOI":"10.1016\/j.xjidi.2021.100025"},{"key":"bibr7-24755303221081799","volume-title":"Census Regions and Divisions of the United States","author":"Bureau 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