{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T01:56:14Z","timestamp":1777859774332,"version":"3.51.4"},"reference-count":37,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2023,2,15]],"date-time":"2023-02-15T00:00:00Z","timestamp":1676419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Psoriasis and Psoriatic Arthritis"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Psoriasis is a systemic inflammatory disorder. It is associated with increased risk of developing other chronic health diseases such cardiovascular disorders. Fetuin A is a glycoprotein that is present in blood serum. It may prevent vascular calcification by forming calciprotien particles; which are formed from their attachment with phosphate and calcium complexes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>The aim of this study was to measure serum Fetuin A in Psoriatic patients and correlate its level with cardiac events and risks in these patients using CT calcium (Ca) scoring.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>24 psoriatic patients (healthy without apparent cardiac risks to detect subclinical events if present) and 24 age and sex matched controls were tested for serum Fetuin A and underwent coronary calcium scoring by multidetector computed tomography (CT) scan. Psoriasis area and severity index (PASI) score for each patient was measured and was correlated with serum Fetuin A and CT calcium (Ca) scoring. Serum Fetuin A was compared between cases and controls and was correlated with coronary calcium score.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>There was highly statistically significant decrease in serum Fetuin A level in psoriatic group compared to control group ( P-value &lt; .001). There was highly statistically significant negative correlation between calcium score and the level of serum Fetuin A ( P-value &lt; .001). No statistically significant correlation was found between the serum level of Fetuin A and the psoriasis severity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Serum Fetuin A is a simple, easy diagnostic tool to evaluate subclinical atherosclerosis in psoriatic patients<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/24755303221135570","type":"journal-article","created":{"date-parts":[[2023,2,15]],"date-time":"2023-02-15T06:49:02Z","timestamp":1676443742000},"page":"66-73","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Can Serum Fetuin-A be Used as a Marker for Cardiovascular Involvement in Psoriatic Patients?"],"prefix":"10.1177","volume":"8","author":[{"given":"Hanan M.","family":"Saleh","sequence":"first","affiliation":[{"name":"Dermatology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aliaa S.","family":"Sheha","sequence":"additional","affiliation":[{"name":"Radio Diagnosis Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nardeen N.","family":"Eskander","sequence":"additional","affiliation":[{"name":"Dermatology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3454-8878","authenticated-orcid":false,"given":"Ahmed F.","family":"Elhawatky","sequence":"additional","affiliation":[{"name":"Dermatology Department, National Research Center, Cairo, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samah I.","family":"Hassen","sequence":"additional","affiliation":[{"name":"Dermatology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,2,15]]},"reference":[{"key":"bibr1-24755303221135570","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-020-01346-6"},{"key":"bibr2-24755303221135570","doi-asserted-by":"crossref","unstructured":"Balato A, Ayala F, Schiattarella M, Megna M, Balato N, Lembo S. (2012) Pathogenesis of psoriasis: The role of pro-inflammatory cytokines produced by Keratinocytes. In: Soung J, Koo B. (eds). Psoriasis. 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(2012): Pathogenesis of psoriasis: The role of pro-inflammatory cytokines produced by Keratinocytes. In: Soung J, Koo B. (eds). Psoriasis. 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