{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T15:50:47Z","timestamp":1782489047187,"version":"3.54.5"},"reference-count":45,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T00:00:00Z","timestamp":1782172800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["K23HL152013 (MSG)"],"award-info":[{"award-number":["K23HL152013 (MSG)"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["R35HL144993 (JSB)"],"award-info":[{"award-number":["R35HL144993 (JSB)"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["R01HL139909 (JSB)"],"award-info":[{"award-number":["R01HL139909 (JSB)"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["P50AR070590 (NLW)"],"award-info":[{"award-number":["P50AR070590 (NLW)"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["R01AR073196 (NLW)"],"award-info":[{"award-number":["R01AR073196 (NLW)"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["R01AR084312 (NLW)"],"award-info":[{"award-number":["R01AR084312 (NLW)"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100003185","name":"National Psoriasis Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100003185","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Psoriasis and Psoriatic Arthritis\u00ae"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Psoriasis is a chronic immune-mediated inflammatory disease associated with heightened cardiovascular risk. Platelets are increasingly implicated in this link through their capacity to amplify vascular inflammation and interact with leukocytes. Circulating leukocyte\u2013platelet aggregates are elevated in psoriasis, although the biological significance of these aggregates remains incompletely understood. We investigated whether increased leukocyte\u2013platelet aggregates is associated with alterations in the platelet transcriptomic profile in psoriasis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Leukocyte\u2013platelet aggregate levels were compared between psoriasis patients (n = 42) and healthy controls (n = 29). Psoriasis patients were stratified by the cohort median lymphocyte-platelet aggregate (LyPA) or neutrophil-platelet aggregate (NPA) levels into high vs low aggregate groups. Platelet RNA sequencing was then performed to define transcriptomic differences in high-vs low-aggregate psoriasis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Psoriasis patients (mean age 46; 60% male; 81% Caucasian) had higher LyPA (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.001) and NPA (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.04) compared with healthy controls (mean age 42; 55% male; 69% Caucasian). Platelet RNA sequencing revealed that psoriasis patients with high LyPA or high NPA had downregulation of platelet inflammatory pathways, including interferon, tumor necrosis factor (TNF), IL-8, and IL-6 signaling.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings identify inflammatory platelet transcriptomic alterations associated with elevated lymphocyte-platelet and neutrophil-platelet aggregates in psoriasis and motivate further work to define the functional consequences of leukocyte-platelet aggregates in psoriasis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/24755303261464144","type":"journal-article","created":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T20:24:09Z","timestamp":1782246249000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Lymphocyte-Platelet and Neutrophil-Platelet Aggregates are Associated with Dysregulated Platelet Inflammatory Pathways in Psoriasis"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-7259-3481","authenticated-orcid":false,"given":"Richard","family":"Ni","sequence":"first","affiliation":[{"name":"NYU School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle L.","family":"Boothman","sequence":"additional","affiliation":[{"name":"NYU School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filipp","family":"Kazatsker","sequence":"additional","affiliation":[{"name":"NYU School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elliot","family":"Luttrell-Williams","sequence":"additional","affiliation":[{"name":"NYU School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamelia","family":"Drenkova","sequence":"additional","affiliation":[{"name":"NYU School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florencia","family":"Schlamp","sequence":"additional","affiliation":[{"name":"NYU School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Astrid","family":"Jara Pernia","sequence":"additional","affiliation":[{"name":"NYU School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole L.","family":"Ward","sequence":"additional","affiliation":[{"name":"Vanderbilt University Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brittany","family":"Weber","sequence":"additional","affiliation":[{"name":"University of Texas Southwestern"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tessa J.","family":"Barrett","sequence":"additional","affiliation":[{"name":"NYU School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey S.","family":"Berger","sequence":"additional","affiliation":[{"name":"NYU School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6649-3755","authenticated-orcid":false,"given":"Michael S.","family":"Garshick","sequence":"additional","affiliation":[{"name":"NYU School of Medicine"},{"name":"NYU School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,6,23]]},"reference":[{"key":"e_1_3_8_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.296.14.1735"},{"key":"e_1_3_8_3_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.829709"},{"key":"e_1_3_8_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2014-205675"},{"key":"e_1_3_8_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2021.02.009"},{"key":"e_1_3_8_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-14365-1"},{"key":"e_1_3_8_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2012.194"},{"key":"e_1_3_8_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.114.304108"},{"key":"e_1_3_8_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.125.322574"},{"key":"e_1_3_8_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.06.053"},{"key":"e_1_3_8_11_2","doi-asserted-by":"publisher","DOI":"10.4172\/2155-9554.1000201"},{"key":"e_1_3_8_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12285"},{"key":"e_1_3_8_13_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra071014"},{"key":"e_1_3_8_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.119.314008"},{"key":"e_1_3_8_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.118.312246"},{"key":"e_1_3_8_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2020.12.025"},{"key":"e_1_3_8_17_2","doi-asserted-by":"publisher","DOI":"10.1159\/000505536"},{"key":"e_1_3_8_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/hc3801.095588"},{"key":"e_1_3_8_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.12.071"},{"key":"e_1_3_8_20_2","doi-asserted-by":"publisher","DOI":"10.1080\/09537104.2018.1430358"},{"key":"e_1_3_8_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2019.08.457"},{"key":"e_1_3_8_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.119.313280"},{"key":"e_1_3_8_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2019.08.026"},{"key":"e_1_3_8_24_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000678"},{"key":"e_1_3_8_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/J.ATHEROSCLEROSIS.2018.12.029"},{"key":"e_1_3_8_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/194927b0"},{"key":"e_1_3_8_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.10.072"},{"key":"e_1_3_8_28_2","unstructured":"Andrews S. (2010). FastQC: A Quality Control Tool for High Throughput Sequence Data. Babraham Bioinformatics Babraham Institute. http:\/\/www.bioinformatics.babraham.ac.uk\/projects\/fastqc. Accessed November 14 2025."},{"key":"e_1_3_8_29_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btw354"},{"key":"e_1_3_8_30_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bts635"},{"key":"e_1_3_8_31_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btt656"},{"key":"e_1_3_8_32_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0550-8"},{"key":"e_1_3_8_33_2","unstructured":"Kolde R. (2025). pheatmap: Pretty Heatmaps (R package version 1.0.13). https:\/\/raivokolde.r-universe.dev\/pheatmap. Accessed November 7 2025."},{"key":"e_1_3_8_34_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-98141-3"},{"key":"e_1_3_8_35_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0506580102"},{"key":"e_1_3_8_36_2","doi-asserted-by":"publisher","DOI":"10.1101\/060012"},{"key":"e_1_3_8_37_2","doi-asserted-by":"publisher","DOI":"10.1111\/ijlh.12051"},{"key":"e_1_3_8_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2024.109092"},{"key":"e_1_3_8_39_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2006.01817.x"},{"key":"e_1_3_8_40_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01867"},{"key":"e_1_3_8_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacbts.2018.10.008"},{"key":"e_1_3_8_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rpth.2023.102261"},{"key":"e_1_3_8_43_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1601708"},{"key":"e_1_3_8_44_2","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0213074"},{"key":"e_1_3_8_45_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.115.306847"},{"key":"e_1_3_8_46_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-04-640300"}],"container-title":["Journal of Psoriasis and Psoriatic Arthritis\u00ae"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/24755303261464144","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/24755303261464144","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/24755303261464144","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T15:16:51Z","timestamp":1782487011000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/24755303261464144"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,23]]},"references-count":45,"alternative-id":["10.1177\/24755303261464144"],"URL":"https:\/\/doi.org\/10.1177\/24755303261464144","relation":{},"ISSN":["2475-5303","2475-5311"],"issn-type":[{"value":"2475-5303","type":"print"},{"value":"2475-5311","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,23]]},"article-number":"24755303261464144"}}