{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T13:49:32Z","timestamp":1753883372189,"version":"3.41.2"},"reference-count":49,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Vaccines and Immunotherapy"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:sec><jats:title>Introduction:<\/jats:title><jats:p> Post anti-COVID-19 vaccine lymphadenopathies have been recently described in literature, from different parts of the world. Although there have been studies on lymphadenopathy following mRNA vaccines, there is a paucity of studies on lymphadenopathy following inactivated viral vaccines, such as Covishield. <\/jats:p><\/jats:sec><jats:sec><jats:title>Aim:<\/jats:title><jats:p> In this study, we explored lymphadenopathy subsequent to Covishield vaccine in terms of its various ultrasound parameters in the Indian population. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p> This hospital-based longitudinal study was conducted among 50 adult beneficiaries of Covishield vaccine. Sociodemographic details and relevant clinical history were recorded using a semi-structured performa. Detailed ultrasound (USG) examination of the bilateral axillae was done on the day of vaccination and after 6\u201312\u2009days post vaccination. Vaccine beneficiaries were evaluated for the presence of any vaccine-associated lymphadenopathy and described the presence, number, size, morphology, cortical thickness, and presence or absence of echogenic hilum. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> Out of total (63) lymph nodes evaluated sonologically, majority (80.9%) of lymph nodes showed the features of benign lymphadenopathy. However, 12.6% (8\/63) lymph nodes showed diffusely thickened cortex with preserved central echogenic hilum, 4.76% (3\/63) lymph nodes showed eccentric cortical thickness with preserved hilar pattern, while only one lymph node showed diffuse cortical thickening with loss of central echogenic hilum. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p> With an increase in vaccination coverage, clinicians are likely to confront increasing cases of vaccine-associated axillary lymphadenopathy. Therefore, they should exercise care, that contemporary anti-COVID-19 vaccination can present an aetiology of axillary lymph nodes with suspicious USG features. <\/jats:p><\/jats:sec>","DOI":"10.1177\/25151355221124018","type":"journal-article","created":{"date-parts":[[2022,9,17]],"date-time":"2022-09-17T12:42:36Z","timestamp":1663418556000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Lymphadenopathy subsequent to Covishield (ChAdOx1 nCoV-19) Corona virus vaccine: ultrasound findings and clinical implications"],"prefix":"10.1177","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1341-0239","authenticated-orcid":false,"given":"Soumya Swaroop","family":"Sahoo","sequence":"first","affiliation":[{"name":"Department of Community and Family Medicine, All India Institute of Medical Sciences, Bathinda, Punjab, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0654-3116","authenticated-orcid":false,"given":"Navdeep","family":"Kaur","sequence":"additional","affiliation":[{"name":"Assistant Professor, Department of Radiodiagnosis, All India Institute of Medical Sciences, Bathinda, 151001, Punjab, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amandeep","family":"Kaur","sequence":"additional","affiliation":[{"name":"Department of General Medicine, All India Institute of Medical Sciences, Bathinda, Punjab, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shivane","family":"Garg","sequence":"additional","affiliation":[{"name":"Department of Radiodiagnosis, All India Institute of Medical Sciences, Bathinda, Punjab, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,9,17]]},"reference":[{"key":"bibr1-25151355221124018","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2001316"},{"key":"bibr2-25151355221124018","doi-asserted-by":"publisher","DOI":"10.1055\/s-0040-1712187"},{"key":"bibr3-25151355221124018","doi-asserted-by":"publisher","DOI":"10.1038\/d41586-020-03626-1"},{"key":"bibr4-25151355221124018","unstructured":"US Food and Drug Administration. COVID-19 vaccines [Internet], 2022, https:\/\/www.fda.gov\/emergency-preparedness-and-response\/coronavirus-disease-2019-covid-19\/covid-19-vaccines (accessed 30 March 2022)."},{"key":"bibr5-25151355221124018","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms9030605"},{"key":"bibr6-25151355221124018","first-page":"1","author":"Kumar VM","year":"2021","journal-title":"Npj Vaccines"},{"key":"bibr7-25151355221124018","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2034577"},{"key":"bibr8-25151355221124018","unstructured":"Centre for Disease Control and Prevention. Pfizer-BioNTech COVID-19 vaccine reactions & adverse events. CDC [Internet], 2020, https:\/\/www.cdc.gov\/vaccines\/covid-19\/info-by-product\/pfizer\/reactogenicity.html (accessed 30 March 2022)."},{"key":"bibr9-25151355221124018","doi-asserted-by":"publisher","DOI":"10.1007\/s40477-020-00458-7"},{"key":"bibr10-25151355221124018","doi-asserted-by":"publisher","DOI":"10.1007\/s40477-021-00575-x"},{"key":"bibr11-25151355221124018","doi-asserted-by":"publisher","DOI":"10.7774\/cevr.2019.8.2.89"},{"key":"bibr12-25151355221124018","doi-asserted-by":"publisher","DOI":"10.1007\/s13244-014-0367-8"},{"key":"bibr13-25151355221124018","doi-asserted-by":"publisher","DOI":"10.7863\/jum.2004.23.1.63"},{"key":"bibr14-25151355221124018","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(02)00748-7"},{"key":"bibr15-25151355221124018","doi-asserted-by":"publisher","DOI":"10.1259\/bjr\/95130566"},{"key":"bibr16-25151355221124018","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.183.6.01831779"},{"key":"bibr17-25151355221124018","first-page":"10","author":"Cocco G","year":"2021","journal-title":"Biology (Basel)"},{"key":"bibr18-25151355221124018","doi-asserted-by":"publisher","DOI":"10.1592\/phco.28.9.1194"},{"key":"bibr19-25151355221124018","doi-asserted-by":"publisher","DOI":"10.1007\/s12149-011-0568-x"},{"key":"bibr20-25151355221124018","unstructured":"And EC and for DP. COVID-19 vaccines [Internet], 2021, https:\/\/vaccination-info.eu\/en\/covid-19\/covid-19-vaccines (accessed 3 April 2022)."},{"key":"bibr21-25151355221124018","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.5374"},{"key":"bibr22-25151355221124018","doi-asserted-by":"publisher","DOI":"10.1016\/j.crad.2021.04.010"},{"key":"bibr23-25151355221124018","unstructured":"Centers for Disease Control and Prevention (CDC). Moderna COVID-19 vaccine\u2019s reactions and adverse events. CDC [Internet], 2021, https:\/\/www.cdc.gov\/vaccines\/covid-19\/info-by-product\/moderna\/reactogenicity.html (accessed 3 April 2022)."},{"key":"bibr24-25151355221124018","unstructured":"Agency EM. COVID-19 Vaccine Janssen. European Medicines Agency [Internet], 2021, https:\/\/www.ema.europa.eu\/en\/medicines\/human\/EPAR\/covid-19-vaccine-janssen (accessed 30 March 2022)."},{"key":"bibr25-25151355221124018","unstructured":"GOV.UK. Regulatory approval of COVID-19 Vaccine AstraZeneca. GOV.UK [Internet]. 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