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There is increasing recognition that the hijacking of VAP by intracellular pathogens is a novel mechanism of host\u2013pathogen interaction. Here, we summarize our recent findings showing that the Chlamydia inclusion membrane protein IncV tethers the ER to the inclusion membrane by binding to VAP via the molecular mimicry of two eukaryotic FFAT motifs. We extend the discussion to other microorganisms that have evolved similar mechanisms.<\/jats:p>","DOI":"10.1177\/2515256418775512","type":"journal-article","created":{"date-parts":[[2018,5,17]],"date-time":"2018-05-17T07:29:01Z","timestamp":1526542141000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Making Contact: VAP Targeting by Intracellular Pathogens"],"prefix":"10.1177","volume":"1","author":[{"given":"Rebecca","family":"Murray","sequence":"first","affiliation":[{"name":"Department of Microbiology, Immunology, and Cancer Biology, University of Virginia, Charlottesville, VA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabelle","family":"Derr\u00e9","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology, and Cancer Biology, University of Virginia, Charlottesville, VA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2018,5,17]]},"reference":[{"key":"bibr1-2515256418775512","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002092"},{"key":"bibr2-2515256418775512","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002198"},{"key":"bibr3-2515256418775512","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.082602"},{"key":"bibr4-2515256418775512","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01952-17"},{"key":"bibr5-2515256418775512","doi-asserted-by":"publisher","DOI":"10.1111\/cmi.12637"},{"key":"bibr6-2515256418775512","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00668-17"},{"key":"bibr7-2515256418775512","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fcimb.2014.00157","volume":"4","author":"Moore E. 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