{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T06:31:39Z","timestamp":1790231499091,"version":"4.1.0"},"reference-count":59,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["Emmy-Noether KR1566\/1-1"],"award-info":[{"award-number":["Emmy-Noether KR1566\/1-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004189","name":"Max-Planck Society for the Advancement of Science","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004189","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Helmholtz HGF project Aging and Metabolic Programming"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Contact"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:p>Lipid droplets (LDs), important organelles for energy storage and involved in the development of metabolic disorders, are extremely dynamic and interact with many other cellular compartments to orchestrate lipid metabolism. Little is known about how these organelle contacts are changed according to cellular needs and functions under different metabolic and pathological conditions and which proteins regulate this. Here, we summarize recent exciting discoveries about the reorganization of organelle contacts in steatotic liver, including the identification of novel LD contact site proteins in cell lines and in animals. We also discuss state of the art proteomics workflows that enable the characterization of LD-organelle contacts and tethering proteins and give an outlook how this can inform obesity research.<\/jats:p>","DOI":"10.1177\/2515256419859186","type":"journal-article","created":{"date-parts":[[2019,7,4]],"date-time":"2019-07-04T11:19:45Z","timestamp":1562239185000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Catching Lipid Droplet Contacts by Proteomics"],"prefix":"10.1177","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4063-7367","authenticated-orcid":false,"given":"Natalie","family":"Krahmer","sequence":"first","affiliation":[{"name":"Institute for Diabetes and Obesity, Helmholtz Zentrum M\u00fcnchen, Munich-Neuherberg, Germany"},{"name":"Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Martinsried, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Mann","sequence":"additional","affiliation":[{"name":"Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Martinsried, Germany"},{"name":"Faculty of Health Sciences, NNF Center for Protein Research, University of Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,7,4]]},"reference":[{"key":"bibr1-2515256419859186","doi-asserted-by":"publisher","DOI":"10.1038\/nature02166"},{"key":"bibr2-2515256419859186","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3735"},{"key":"bibr3-2515256419859186","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2015.01.013"},{"key":"bibr4-2515256419859186","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201804111"},{"key":"bibr5-2515256419859186","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2018.03.003"},{"key":"bibr6-2515256419859186","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2017.11.020"},{"key":"bibr7-2515256419859186","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2012.10.009"},{"key":"bibr8-2515256419859186","doi-asserted-by":"publisher","DOI":"10.1042\/BC20110024"},{"key":"bibr9-2515256419859186","doi-asserted-by":"publisher","DOI":"10.15252\/embj.201694914"},{"key":"bibr10-2515256419859186","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2006.07.062"},{"key":"bibr11-2515256419859186","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2015.07.006"},{"key":"bibr12-2515256419859186","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M113.031591"},{"key":"bibr13-2515256419859186","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1006516"},{"key":"bibr14-2515256419859186","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M050229"},{"key":"bibr15-2515256419859186","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb1194"},{"key":"bibr16-2515256419859186","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.T400009-MCP200"},{"key":"bibr17-2515256419859186","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2016.10.022"},{"key":"bibr18-2515256419859186","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-48382-5_8"},{"key":"bibr19-2515256419859186","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.03.022"},{"key":"bibr20-2515256419859186","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-08191-w"},{"key":"bibr21-2515256419859186","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2018.08.016"},{"key":"bibr22-2515256419859186","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2016.06.015"},{"key":"bibr23-2515256419859186","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1717978115"},{"key":"bibr24-2515256419859186","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.16950"},{"key":"bibr25-2515256419859186","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201610055"},{"key":"bibr26-2515256419859186","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M056812"},{"key":"bibr27-2515256419859186","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2016.02.007"},{"key":"bibr28-2515256419859186","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2015.06.007"},{"key":"bibr29-2515256419859186","doi-asserted-by":"publisher","DOI":"10.1002\/emmm.201100671"},{"key":"bibr30-2515256419859186","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2011.07.013"},{"key":"bibr31-2515256419859186","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M112.020230"},{"key":"bibr32-2515256419859186","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2018.09.017"},{"key":"bibr33-2515256419859186","doi-asserted-by":"publisher","DOI":"10.1016\/j.jprot.2018.04.024"},{"key":"bibr34-2515256419859186","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201807019"},{"key":"bibr35-2515256419859186","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2006.08.036"},{"key":"bibr36-2515256419859186","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.16988"},{"key":"bibr37-2515256419859186","doi-asserted-by":"crossref","unstructured":"Munro S (2011). The golgin coiled-coil proteins of the Golgi apparatus.\n                      Cold Spring Harb Perspect Biol\n                      3.a005256.","DOI":"10.1101\/cshperspect.a005256"},{"key":"bibr38-2515256419859186","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2017.06.003"},{"key":"bibr39-2515256419859186","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-018-0085-z"},{"key":"bibr40-2515256419859186","doi-asserted-by":"crossref","unstructured":"Pandya NJ, Koopmans F, Slotman JA, Paliukhovich I, Houtsmuller AB, Smit AB, Li KW (2017). Correlation profiling of brain sub-cellular proteomes reveals co-assembly of synaptic proteins and subcellular distribution.\n                      Sci Rep\n                      7, 12107.","DOI":"10.1038\/s41598-017-11690-3"},{"key":"bibr41-2515256419859186","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2017.12.011"},{"key":"bibr42-2515256419859186","doi-asserted-by":"publisher","DOI":"10.1007\/s13238-011-1061-y"},{"key":"bibr43-2515256419859186","doi-asserted-by":"publisher","DOI":"10.1021\/pr500880b"},{"key":"bibr44-2515256419859186","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.5370"},{"key":"bibr45-2515256419859186","doi-asserted-by":"publisher","DOI":"10.15252\/embj.201695170"},{"key":"bibr46-2515256419859186","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-408051-5.00002-4"},{"key":"bibr47-2515256419859186","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2017.06.005"},{"key":"bibr48-2515256419859186","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201809067"},{"key":"bibr49-2515256419859186","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.199661"},{"key":"bibr50-2515256419859186","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2015.00079"},{"key":"bibr51-2515256419859186","doi-asserted-by":"publisher","DOI":"10.1038\/nature22369"},{"key":"bibr52-2515256419859186","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-018-0037-8"},{"key":"bibr53-2515256419859186","doi-asserted-by":"publisher","DOI":"10.1021\/ac015704l"},{"key":"bibr54-2515256419859186","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M700169-MCP200"},{"key":"bibr55-2515256419859186","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2013.01.013"},{"key":"bibr56-2515256419859186","doi-asserted-by":"publisher","DOI":"10.1126\/science.1256898"},{"key":"bibr57-2515256419859186","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2018.09.010"},{"key":"bibr58-2515256419859186","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2015.01.020"},{"key":"bibr59-2515256419859186","first-page":"84","volume":"3","author":"Zhang X","year":"2015","journal-title":"Front Cell Dev Biol"}],"container-title":["Contact"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2515256419859186","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/2515256419859186","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2515256419859186","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:26:42Z","timestamp":1777397202000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/2515256419859186"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":59,"alternative-id":["10.1177\/2515256419859186"],"URL":"https:\/\/doi.org\/10.1177\/2515256419859186","relation":{},"ISSN":["2515-2564","2515-2564"],"issn-type":[{"value":"2515-2564","type":"print"},{"value":"2515-2564","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1]]},"article-number":"2515256419859186"}}