{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T23:55:12Z","timestamp":1787702112894,"version":"build-2784847793"},"reference-count":78,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Universidad Veracruzana and Universidad Aut\u00f3noma de Tlaxcala","award":["UVE-CA-25 and UATX-CA-215"],"award-info":[{"award-number":["UVE-CA-25 and UATX-CA-215"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Evid Based Complementary Altern Med"],"published-print":{"date-parts":[[2018,1,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background.<\/jats:title>\n                    <jats:p>Montanoa frutescens and Montanoa grandiflora have been indistinctly used for centuries in traditional Mexican medicine for reproductive impairments, anxiety, and mood disorders. Preclinical studies support their aphrodisiac and anxiolytic properties, but their effects on mood are still unexplored.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods.<\/jats:title>\n                    <jats:p>\n                      The effects of 25 and 50 mg\/kg of M frutescens and M grandiflora extracts were evaluated on days 1, 7, 14, 21, and 28 of treatment, and compared with fluoxetine (1 mg\/kg) and Remotiv (7.14 mg\/kg) in Wistar rats. The participation of GABA\n                      <jats:sub>A<\/jats:sub>\n                      receptor in the effects produced by the treatments was explored.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results.<\/jats:title>\n                    <jats:p>\n                      Montanoa extracts reduced immobility since day 1 of treatment, while fluoxetine and Remotiv required 14 days. The GABA\n                      <jats:sub>A<\/jats:sub>\n                      antagonism blocked the effects of Montanoa extracts, but not of fluoxetine or Remotiv.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions.<\/jats:title>\n                    <jats:p>\n                      Montanoa extracts prevented quickly the stress-induced behaviors in the swimming test through action at the GABA\n                      <jats:sub>A<\/jats:sub>\n                      receptor, exerting a protective effect different to the typical antidepressants drugs.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/2515690x18762953","type":"journal-article","created":{"date-parts":[[2018,3,15]],"date-time":"2018-03-15T13:28:28Z","timestamp":1521120508000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":19,"title":["The Aqueous Crude Extracts of\n                    <i>Montanoa frutescens<\/i>\n                    and\n                    <i>Montanoa grandiflora<\/i>\n                    Reduce Immobility Faster Than Fluoxetine Through GABA\n                    <sub>A<\/sub>\n                    Receptors in Rats Forced to Swim"],"prefix":"10.1177","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5837-103X","authenticated-orcid":false,"given":"Juan Francisco","family":"Rodr\u00edguez-Landa","sequence":"first","affiliation":[{"name":"Universidad Veracruzana, Xalapa, Veracruz, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1465-012X","authenticated-orcid":false,"given":"Jonathan","family":"Cueto-Escobedo","sequence":"additional","affiliation":[{"name":"Universidad Veracruzana, Xalapa, Veracruz, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis \u00c1ngel","family":"Flores-Aguilar","sequence":"additional","affiliation":[{"name":"Universidad Veracruzana, Xalapa, Veracruz, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilberto Uriel","family":"Rosas-S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Universidad Veracruzana, Xalapa, Veracruz, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda de Jes\u00fas","family":"Rovirosa-Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Universidad Veracruzana, Xalapa, Veracruz, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Garc\u00eda-Ordu\u00f1a","sequence":"additional","affiliation":[{"name":"Universidad Veracruzana, Xalapa, Veracruz, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Carro-Ju\u00e1rez","sequence":"additional","affiliation":[{"name":"Universidad Aut\u00f3noma de Tlaxcala, Tlaxcala, Mexico"},{"name":"In memoriam."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2018,3,14]]},"reference":[{"key":"bibr1-2515690X18762953","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"bibr2-2515690X18762953","doi-asserted-by":"publisher","DOI":"10.2298\/VSP1204308M"},{"key":"bibr3-2515690X18762953","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2013.10.015"},{"key":"bibr4-2515690X18762953","doi-asserted-by":"publisher","DOI":"10.1007\/s00406-007-0779-2"},{"key":"bibr5-2515690X18762953","doi-asserted-by":"publisher","DOI":"10.2174\/138920009790711878"},{"key":"bibr6-2515690X18762953","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.2011.00904.x"},{"key":"bibr7-2515690X18762953","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-5846(03)00175-1"},{"key":"bibr8-2515690X18762953","doi-asserted-by":"publisher","DOI":"10.1097\/01.chi.0000183464.41777.c1"},{"key":"bibr9-2515690X18762953","first-page":"81","volume-title":"Hypericum: Botanical Sources, Medical Properties and Health Effects","author":"Rodr\u00edguez-Landa JF","year":"2015"},{"key":"bibr10-2515690X18762953","doi-asserted-by":"publisher","DOI":"10.1078\/0944-7113-00340"},{"key":"bibr11-2515690X18762953","volume-title":"Libellus de Medicinalibus Indorum Herbis 1552","author":"Codex de la Cruz-Badiano","year":"1964"},{"key":"bibr12-2515690X18762953","volume-title":"Quatro libros de la naturaleza y virtudes de las plantas y animales que est\u00e1n recevidos en el uso de medicina en la Nueva Espa\u00f1aa, y la m\u00e9todo, y correcci\u00f3n y preperaci\u00f3n que para administrarllas se requiere con lo que el doctor Francisco Hern\u00e1ndez escrivio en lengua latina, viuda de Diego L\u00f3pez Davalos","author":"Ximenez F","year":"1615"},{"key":"bibr13-2515690X18762953","first-page":"524","volume":"26","author":"Levine SD","year":"1981","journal-title":"J Reprod Med"},{"key":"bibr14-2515690X18762953","doi-asserted-by":"publisher","DOI":"10.1016\/0010-7824(85)90084-8"},{"key":"bibr15-2515690X18762953","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2004.03.001"},{"key":"bibr16-2515690X18762953","doi-asserted-by":"publisher","DOI":"10.1177\/2156587213510006"},{"key":"bibr17-2515690X18762953","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2012.07.022"},{"key":"bibr18-2515690X18762953","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/938060"},{"key":"bibr19-2515690X18762953","first-page":"37","volume":"4","author":"Rodr\u00edguez-Landa JF","year":"2014","journal-title":"J Chem Biol Phys Sci"},{"key":"bibr20-2515690X18762953","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2014.12.070"},{"key":"bibr21-2515690X18762953","volume-title":"Efecto de la infusi\u00f3n de Cihuapatli (Montanoa tomentosa) en ratas hembra de la cepa Wistar forzadas a nadar [bachelor\u2019s thesis]","author":"Bald\u00e9s-Baizabal C","year":"2007"},{"key":"bibr22-2515690X18762953","doi-asserted-by":"publisher","DOI":"10.1016\/S0188-0128(99)00024-X"},{"key":"bibr23-2515690X18762953","doi-asserted-by":"publisher","DOI":"10.1177\/0269881106064203"},{"key":"bibr24-2515690X18762953","doi-asserted-by":"publisher","DOI":"10.1097\/FBP.0b013e328331b9f2"},{"key":"bibr25-2515690X18762953","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2012.09.002"},{"key":"bibr26-2515690X18762953","volume-title":"Guide for the Care and Use of Laboratory Animals: A Report of the Institute of Laboratory Animal Resource Committee on the Care and Use of Laboratory Animals [NIH publication no. 85-23]","author":"National Research Council","year":"1996"},{"key":"bibr27-2515690X18762953","volume-title":"Especificaciones t\u00e9cnicas para la producci\u00f3n, cuidado y uso de los animales de laboratorio","author":"Norma Oficial Mexicana NOM-062-ZOO-1999","year":"1999"},{"key":"bibr28-2515690X18762953","doi-asserted-by":"crossref","unstructured":"Thiers B. [continuously updated]. Index herbarium: a global directory of public herbaria and associated staff, New York Botanical Garden\u2019s Virtual Herbarium; 2016. http:\/\/sweetgum.nybg.org\/science\/ih\/.","DOI":"10.1007\/s12228-016-9423-7"},{"key":"bibr29-2515690X18762953","volume-title":"Phytochemical research methods","author":"Dom\u00ednguez XA.","year":"1973"},{"key":"bibr30-2515690X18762953","volume-title":"Textbook of Pharmacognosy","author":"Trease GE","year":"1983","edition":"12"},{"key":"bibr31-2515690X18762953","first-page":"203","volume":"8","author":"Obadoni BO","year":"2001","journal-title":"Global J Pure Appl Sci"},{"key":"bibr32-2515690X18762953","volume-title":"Natural Products From Plants","author":"Cseka LJ","year":"2006"},{"key":"bibr33-2515690X18762953","first-page":"131","volume":"4","author":"Lozano-Hern\u00e1ndez R","year":"2010","journal-title":"J Med Plant Res"},{"key":"bibr34-2515690X18762953","doi-asserted-by":"publisher","DOI":"10.1177\/026988110101500401"},{"key":"bibr35-2515690X18762953","doi-asserted-by":"publisher","DOI":"10.1007\/s002130050136"},{"key":"bibr36-2515690X18762953","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2004.11.010"},{"key":"bibr37-2515690X18762953","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-5846(98)00066-9"},{"key":"bibr38-2515690X18762953","first-page":"319","volume":"6","author":"Molina M","year":"1999","journal-title":"Mimosa pudica may possess antidepressant actions in the rat. Phytomedicine"},{"key":"bibr39-2515690X18762953","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2010.12.015"},{"key":"bibr40-2515690X18762953","doi-asserted-by":"publisher","DOI":"10.1038\/266730a0"},{"key":"bibr41-2515690X18762953","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-4328(02)00023-2"},{"key":"bibr42-2515690X18762953","volume-title":"The Principles of Humane Experimental Technique","author":"Russell WMS","year":"1959"},{"key":"bibr43-2515690X18762953","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(98)00258-9"},{"key":"bibr44-2515690X18762953","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2009.06.018"},{"key":"bibr45-2515690X18762953","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(02)01405-1"},{"key":"bibr46-2515690X18762953","doi-asserted-by":"publisher","DOI":"10.1007\/BF02245592"},{"key":"bibr47-2515690X18762953","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2004.05.016"},{"key":"bibr48-2515690X18762953","doi-asserted-by":"publisher","DOI":"10.1016\/S0924-977X(02)00173-6"},{"key":"bibr49-2515690X18762953","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2013.144"},{"key":"bibr50-2515690X18762953","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2009.09.017"},{"key":"bibr51-2515690X18762953","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6882-11-7"},{"key":"bibr52-2515690X18762953","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2013.00066"},{"key":"bibr53-2515690X18762953","first-page":"309","volume":"34","author":"Contreras CM","year":"2011","journal-title":"Salud Mental"},{"key":"bibr54-2515690X18762953","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2010.04.035"},{"key":"bibr55-2515690X18762953","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2011.10.006"},{"key":"bibr56-2515690X18762953","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2826.1995.tb00744.x"},{"key":"bibr57-2515690X18762953","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-6147(99)01413-3"},{"key":"bibr58-2515690X18762953","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-3057(97)00540-6"},{"key":"bibr59-2515690X18762953","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-3057(03)00133-3"},{"key":"bibr60-2515690X18762953","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-3806(00)00012-2"},{"key":"bibr61-2515690X18762953","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2008.12.024"},{"key":"bibr62-2515690X18762953","doi-asserted-by":"publisher","DOI":"10.1254\/jjp.48.479"},{"key":"bibr63-2515690X18762953","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(00)00332-0"},{"key":"bibr64-2515690X18762953","doi-asserted-by":"publisher","DOI":"10.1111\/jcpt.12238"},{"key":"bibr65-2515690X18762953","doi-asserted-by":"publisher","DOI":"10.1016\/0010-7824(83)90001-X"},{"key":"bibr66-2515690X18762953","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9422(00)84911-0"},{"key":"bibr67-2515690X18762953","first-page":"157","volume":"19","author":"Guzm\u00e1n-Dur\u00e1n A","year":"1988","journal-title":"Arch Invest M\u00e9d (Mex)"},{"key":"bibr68-2515690X18762953","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pharmtox.47.120505.105237"},{"key":"bibr69-2515690X18762953","doi-asserted-by":"publisher","DOI":"10.1023\/A:1027303609517"},{"key":"bibr70-2515690X18762953","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2015.07.013"},{"key":"bibr71-2515690X18762953","doi-asserted-by":"publisher","DOI":"10.2174\/1568026616666160204121039"},{"key":"bibr72-2515690X18762953","first-page":"2018","volume":"2963565","author":"Germ\u00e1n-Ponciano LJ","year":"2018","journal-title":"Scientifica (Cairo)"},{"key":"bibr73-2515690X18762953","doi-asserted-by":"publisher","DOI":"10.2174\/1568026023393462"},{"key":"bibr74-2515690X18762953","doi-asserted-by":"publisher","DOI":"10.1055\/s-2002-36357"},{"key":"bibr75-2515690X18762953","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1681.1999.03151.x"},{"key":"bibr76-2515690X18762953","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-59745-465-0_1"},{"key":"bibr77-2515690X18762953","doi-asserted-by":"publisher","DOI":"10.1007\/s12272-013-0229-9"},{"key":"bibr78-2515690X18762953","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharep.2017.03.001"}],"container-title":["Journal of Evidence-Based Integrative Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2515690X18762953","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/2515690X18762953","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2515690X18762953","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T15:09:38Z","timestamp":1777388978000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/2515690X18762953"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,1]]},"references-count":78,"alternative-id":["10.1177\/2515690X18762953"],"URL":"https:\/\/doi.org\/10.1177\/2515690x18762953","relation":{},"ISSN":["2515-690X","2515-690X"],"issn-type":[{"value":"2515-690X","type":"print"},{"value":"2515-690X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,1]]},"article-number":"2515690X18762953"}}