{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T22:04:30Z","timestamp":1790633070515,"version":"4.1.0"},"reference-count":34,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Noguchi Memorial Institute for Medical Research, University of Ghana and Science and Technology Research Partnership for Sustainable Development (SATREPS), Japan"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Evid Based Complementary Altern Med"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>\n                    Malaria affects about half of the world's population. The sub-Saharan African region is the most affected. Plant natural products have been a major source of antimalarial drugs; the first (quinine) and present (artemisinin) antimalarials are of natural product origin. Some secondary metabolites demonstrate adjuvant antioxidant effects and selective activity. The focus of this study was to investigate the anti-plasmodial activity, cytotoxicities and antioxidant properties of eight (8) Ghanaian medicinal plants. The anti-plasmodial activity was determined using the SYBR green assay and the tetrazolium-based colorimetric assay (MTT) was employed to assess cytotoxicity of extracts to human RBCs and HL-60 cells. Antioxidant potential of plant extracts was evaluated using Folin-Ciocalteu and superoxide dismutase assays. Phytochemical contstituents of the plant extracts were also assessed. All the extracts demonstrated anti-plasmodial activities at concentrations &lt;50\u2005\u03bcg\/ml. Parkia clappertoniana and Terminalia ivorensis elicited the strongest anti-plasmodial activities with 50% inhibitory concentrations (IC\n                    <jats:sub>50<\/jats:sub>\n                    ) of 1.13 \u03bcg\/ml and 0.95 \u03bcg\/ml, respectively. This is the first report on anti-plasmodial activities of Baphia nitida, Tabernaemontana crassa and Treculia Africana. T. Africana showed moderate anti-plasmodial activity with IC\n                    <jats:sub>50<\/jats:sub>\n                    value of 6.62\u2005\u00b5g\/mL. Extracts of P. clappertoniana, T. Africana and T. ivorensis (0.4\u2005mg\/mL) showed &gt;50% antioxidant effect (SOD). The extracts were not cytotoxicity towards RBCs at the concentration tested (200 \u03bcg\/ml) but were weakly cytotoxic to HL-60 cell. Selectivity indices of most of the extracts were greater than 10. Our results suggest that most of the plant extracts have strong anti-plasmodial activity and antioxidant activity which warrants further investigations.\n                  <\/jats:p>","DOI":"10.1177\/2515690x211073709","type":"journal-article","created":{"date-parts":[[2022,1,17]],"date-time":"2022-01-17T08:19:09Z","timestamp":1642407549000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":18,"title":["Anti-plasmodial, Cytotoxic and Antioxidant Activities of Selected Ghanaian Medicinal Plants"],"prefix":"10.1177","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4219-7107","authenticated-orcid":false,"given":"Regina","family":"Appiah-Opong","sequence":"first","affiliation":[{"name":"Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Accra, Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kojo","family":"Agyemang","sequence":"additional","affiliation":[{"name":"Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Accra, Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eunice","family":"Dotse","sequence":"additional","affiliation":[{"name":"Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Accra, Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Atchoglo","sequence":"additional","affiliation":[{"name":"Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Accra, Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kofi Baffour-Awuah","family":"Owusu","sequence":"additional","affiliation":[{"name":"Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Accra, Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abigail","family":"Aning","sequence":"additional","affiliation":[{"name":"Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Accra, Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxwell","family":"Sakyiamah","sequence":"additional","affiliation":[{"name":"Centre for Plant Medicine Research, Mampong-Akuapim, Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Adegle","sequence":"additional","affiliation":[{"name":"Centre for Plant Medicine Research, Mampong-Akuapim, Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1691-5646","authenticated-orcid":false,"given":"Frederick","family":"Ayertey","sequence":"additional","affiliation":[{"name":"Centre for Plant Medicine Research, Mampong-Akuapim, Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfred Ampomah","family":"Appiah","sequence":"additional","affiliation":[{"name":"Centre for Plant Medicine Research, Mampong-Akuapim, Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander K.","family":"Nyarko","sequence":"additional","affiliation":[{"name":"University of Ghana School of Pharmacy, College of Health Sciences, University of Ghana, Accra, Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,1,17]]},"reference":[{"key":"bibr1-2515690X211073709","unstructured":"WHO, The World malaria report 2019. 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