{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T01:57:10Z","timestamp":1782698230824,"version":"3.54.5"},"reference-count":69,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Evid Based Complementary Altern Med"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background and purpose<\/jats:title>\n                    <jats:p>Candida infections have increased significantly in the antimicrobial resistance era, and synthetic antifungal drugs have limitations. The present work aimed to review the antifungal properties of Zataria multiflora ( Z. multiflora) as an herbal remedy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>PubMed, Scopus, ScienceDirect, Web of Science, SID, Civilica, and Magiran databases were searched for the antifungal activity on in vitro, in vivo, dental biofilm, and clinical studies of Z. multiflora on Candida species.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Overall, 33 articles evaluated the effect of Z. multiflora on Candida species and classified them into four groups, as follows in vitro (23), dental biofilm (6), in vivo (2), and clinical studies (3). All studies considered Z. multiflora effective in reducing or even inhibiting the growth of Candida species. NoMFC significant differences were seen in the effect of Z. multiflora on susceptible Candida compared to the resistant groups of Candida in the studies. It was also influential in inhibiting C. parapsilosis, C. glabrata, C. krusei, C. kefyer, and C. zeylanoides.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Considering the side effects and resistance of current antifungal drugs as well as the benefits of using herbal medicines, such as lower cost, less likely to develop drug resistance, the absence of side effects, and toxicity compared with chemical ones, it is possible as a powerful alternative to replace or combine with the current antifungal for Candida infection therapy along with other therapies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/2515690x221132272","type":"journal-article","created":{"date-parts":[[2022,11,24]],"date-time":"2022-11-24T13:38:17Z","timestamp":1669297097000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Antifungal Properties of\n                    <i>Zataria multiflora<\/i>\n                    on\n                    <i>Candida<\/i>\n                    species: A Systematic Review"],"prefix":"10.1177","volume":"27","author":[{"given":"Ali Malekzadeh","family":"Shafaroudi","sequence":"first","affiliation":[{"name":"Dentistry Student, Student Research Committee, Faculty of Dentistry, Mazandaran University of Medical sciences, Sari, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia Elyassi","family":"Gorji","sequence":"additional","affiliation":[{"name":"Dentistry Student, Student Research Committee, Faculty of Dentistry, Mazandaran University of Medical sciences, Sari, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0968-2584","authenticated-orcid":false,"given":"Pegah","family":"Nasiri","sequence":"additional","affiliation":[{"name":"Dentistry Student, Student Research Committee, Faculty of Dentistry, Mazandaran University of Medical sciences, Sari, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9336-2518","authenticated-orcid":false,"given":"Javad","family":"Javidnia","sequence":"additional","affiliation":[{"name":"Student Research Committee Center, Mazandaran University of Medical Sciences, Sari, Iran"},{"name":"Department of Medical Mycology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Ebrahimi","family":"Saravi","sequence":"additional","affiliation":[{"name":"Assistant Professor, Department of Prosthodontics, Faculty of Dentistry, Mazandaran University of Medical Sciences, Sari, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,11,24]]},"reference":[{"key":"bibr1-2515690X221132272","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-64113-3_3"},{"key":"bibr2-2515690X221132272","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkh046"},{"key":"bibr3-2515690X221132272","doi-asserted-by":"publisher","DOI":"10.1177\/154405910708600304"},{"key":"bibr4-2515690X221132272","doi-asserted-by":"publisher","DOI":"10.4317\/jced.51798"},{"key":"bibr5-2515690X221132272","doi-asserted-by":"publisher","DOI":"10.1080\/14787210.2020.1750368"},{"key":"bibr6-2515690X221132272","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2018.26"},{"key":"bibr7-2515690X221132272","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkw392"},{"key":"bibr8-2515690X221132272","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2006.01.002"},{"key":"bibr9-2515690X221132272","doi-asserted-by":"publisher","DOI":"10.1111\/myc.12330"},{"key":"bibr10-2515690X221132272","doi-asserted-by":"publisher","DOI":"10.1590\/S1678-91992010000300006"},{"key":"bibr11-2515690X221132272","doi-asserted-by":"publisher","DOI":"10.3390\/antiox9121309"},{"key":"bibr12-2515690X221132272","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2006.050141"},{"key":"bibr13-2515690X221132272","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2004.11.016"},{"issue":"14","key":"bibr14-2515690X221132272","first-page":"451","volume":"18","author":"Duarte MCT","year":"2014","journal-title":"BMC Complement Altern Med"},{"key":"bibr15-2515690X221132272","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2012.12.018"},{"key":"bibr16-2515690X221132272","unstructured":"Mozaffarian V. 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