{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T21:40:03Z","timestamp":1777498803614,"version":"3.51.4"},"reference-count":36,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"WALA Heilmittel GmbH, Germany","award":["unrestricted research grant (no number)"],"award-info":[{"award-number":["unrestricted research grant (no number)"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Evid Based Complementary Altern Med"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Sarcoidosis is a chronic, inflammatory, granulomatous, multisystem disease. At the Department of Pneumology of the hospital Gemeinschaftskrankenhaus Havelh\u00f6he, the treatment of sarcoidosis is complemented with a multi-component mixture based on\n                      <jats:italic toggle=\"yes\">Viscum album L.<\/jats:italic>\n                      , mistletoe extracts and Ferrum chloratum according to the Havelh\u00f6he Sarcoidosis Protocol (HSP). The aim of this study was to evaluate the course of disease in sarcoidosis patients treated with HSP.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective cohort study was conducted by evaluating data on clinical progression, pulmonary function, fatigue, and adverse events in a real-world sarcoidosis cohort using descriptive statistics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>956 patients with sarcoidosis were treated with HSP between 2003 and 2022 and a total of 124 consenting patients (all stages, 35% multi-organ sarcoidosis, mean age 43 years, 69% female) were evaluated for clinical outcomes over a median follow-up of 23 months. The response rate for controlling pulmonary disease in this study cohort was 69%. At baseline, 81 patients (65%) had clinically relevant fatigue, which improved in 48 patients (59%) during HSP therapy. At the last follow-up visit, 103 (83%) did not need glucocorticosteroids or other medications and were receiving only HSP. Pharmacovigilant monitoring demonstrated a safe HSP therapeutic profile, with only 10 (8%) subjects experiencing grade 1 adverse events.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The feasibility and safety of complementary HSP therapy in the treatment of sarcoidosis have been demonstrated. These results should be used for the creation of hypotheses and further investigations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/2515690x251345931","type":"journal-article","created":{"date-parts":[[2025,6,6]],"date-time":"2025-06-06T03:11:37Z","timestamp":1749179497000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["New Therapy for Chronic Sarcoidosis with\n                    <i>Viscum Album<\/i>\n                    L. and Ferrum Chloratum Preparations: Results of a Retrospective Survey"],"prefix":"10.1177","volume":"30","author":[{"given":"Christian","family":"Grah","sequence":"first","affiliation":[{"name":"Department of Pneumology and Lung Cancer Centre, Hospital Gemeinschaftskrankenhaus Havelh\u00f6he, Berlin, Germany"},{"name":"Research Institute Havelh\u00f6he at Hospital Gemeinschaftskrankenhaus Havelh\u00f6he, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irina","family":"Gatov","sequence":"additional","affiliation":[{"name":"Gesellschaft f\u00fcr Klinische Forschung e. 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