{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T21:40:21Z","timestamp":1777498821936,"version":"3.51.4"},"reference-count":50,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Faculty of Traditional Thai Medicine, Prince of Songkla University","award":["TTM6404242S"],"award-info":[{"award-number":["TTM6404242S"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Evid Based Complementary Altern Med"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Traditional Thai herbal medicine represents an alternative and complementary approach for managing hyperlipidemia, according to its low toxicity and advantageous benefits. However, there is limited clinical data for Thai herbal medicine formulations for hyperlipidemia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The present study aimed to evaluate the biological and clinical efficacy of Thai herbal formulation for lowering blood lipids in patients with borderline hyperlipidemia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>\n                      The chemical profile,\n                      <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                      antioxidant activity, pancreatic lipase inhibition, and cytotoxicity tests were evaluated in the aqueous and ethanol extracts of Thai herbal formulation. The clinical efficacy and safety of Thai herbal formulation for reducing blood lipids were assessed in patients with borderline hyperlipidemia during a 12-week period.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The main chemical constituents of Thai herbal formulation, including (+)-chebulic acid, 4-glucogallic acid, gallic acid, ellagic acid, piscidic acid, and 6-gingerol, demonstrated anti-oxidant and pancreatic lipase inhibitory effects. In cytotoxicity testing, the aqueous extracts exhibited no inhibitory effect on L929 cells and Vero cells (IC\n                      <jats:sub>50<\/jats:sub>\n                      values above 80 \u03bcg\/mL), whereas the ethanol extracts presented IC\n                      <jats:sub>50<\/jats:sub>\n                      values of 18.59\u2009\u00b1\u20090.58\u2005\u00b5g\/mL in Vero cells and 39.86\u2009\u00b1\u20090.02\u2005\u00b5g\/mL in L929 cells. The clinical investigation revealed that the Thai herbal formulation significantly decreased total cholesterol and low-density lipoprotein levels (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u20090.05), and additionally reduced triglycerides and elevated high-density lipoprotein cholesterol, in comparison to the control group after 12 weeks, thereby demonstrating its efficacy in hyperlipidemia management.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The findings indicated that the Thai herbal formulation exhibited potential as a herbal therapeutic approach for borderline hyperlipidemia management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/2515690x251391671","type":"journal-article","created":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T16:45:22Z","timestamp":1761583522000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Clinical and Biological Efficacy of Thai Herbal Blood Lipid-Lowering Formulation for Borderline Hyperlipidemia: A Double-Blind Multicenter Randomized Controlled Trial"],"prefix":"10.1177","volume":"30","author":[{"given":"Pattaraporn","family":"Bunmee","sequence":"first","affiliation":[{"name":"Prince of Songkla University"},{"name":"Division of Applied Thai Traditional Medicine, Faculty of Public Health, Naresuan University, Phitsanulok, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanan","family":"Subhadhirasakul","sequence":"additional","affiliation":[{"name":"Prince of Songkla University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nattisa","family":"Niyomtham","sequence":"additional","affiliation":[{"name":"Walailak University International College of Dentistry (WUICD)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8673-3384","authenticated-orcid":false,"given":"Thanyaluck","family":"Siriyong","sequence":"additional","affiliation":[{"name":"Prince of Songkla University"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,10,27]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241713288"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-021-00541-4"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2022.13044"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.02.071"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.26538\/tjnpr\/v6i1.6"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.2174\/138161210793176464"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2019.109338"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.00743"},{"key":"e_1_3_3_10_2","volume-title":"Monographs of Selected Thai Materia Medica Volume 1","author":"Department of Thai Traditional and Alternative Medicine","year":"2009","unstructured":"Department of Thai Traditional and Alternative Medicine. 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