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This study aimed to investigate the effects of\n                      <jats:italic toggle=\"yes\">T. chantrieri<\/jats:italic>\n                      crude extract on CD4+ T cell phenotypes and on the phagocytosis and oxidative burst of polymorphonuclear neutrophils (PMNs) in the elderly (ex-vivo). Its ability to inhibit opportunistic and pathogenic bacteria was also evaluated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      <jats:italic toggle=\"yes\">T chantrieri<\/jats:italic>\n                      crude extract was obtained by ethanolic extraction. A total of eight elderly (age \u226565 years) were enrolled in the study. Investigations used flow cytometric analysis. Antimicrobial effects were explored by agar well diffusion and minimum inhibition concentration (MIC) testing.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      CD4+ T cell proportion significantly decreased at the 100\u2005\u03bcg\/ml concentration (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.015). CD4+NKG2D+ T cells decreased at all concentrations (50, 100, 200, 300\u2005\u03bcg\/ml). Regarding PMNs, phagocytosis and oxidative burst in the treated group were significantly increased at 15\u2005min compared with the untreated group (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.039 and 0.015, respectively). Regarding antimicrobial effect, 100\u2005mg\/ml crude extract inhibited\n                      <jats:italic toggle=\"yes\">Staphylococcus epidermidis, Staphylococcus aureus<\/jats:italic>\n                      ,\n                      <jats:italic toggle=\"yes\">Neisseria sicca<\/jats:italic>\n                      , and\n                      <jats:italic toggle=\"yes\">Acinetobacter lwoffii<\/jats:italic>\n                      . MIC values were 1.23, 3.70, 33.33, and 100\u2005mg\/ml, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      This work reports preliminary findings of immunity promotion in the elderly following treatment with\n                      <jats:italic toggle=\"yes\">T. chantrieri<\/jats:italic>\n                      crude extract. In future, the extract may be developed into a natural herb product or a form of alternative medicine for immune status enhancement, as well as a potential antimicrobial agent, particularly in the elderly.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/2515690x261418404","type":"journal-article","created":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T18:15:31Z","timestamp":1769192131000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["<i>Tacca chantrieri<\/i>\n                    (Andre) Crude Extract Promoted Immunity in the Elderly (\n                    <i>Ex-Vivo<\/i>\n                    ), and Inhibited Pathogenic and Opportunistic Bacteria"],"prefix":"10.1177","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-0812-9679","authenticated-orcid":false,"given":"Chitsanucha","family":"Chatsakulphanit","sequence":"first","affiliation":[{"name":"Khon Kaen University"},{"name":"Khon Kaen University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3683-5862","authenticated-orcid":false,"given":"Supranee","family":"Phanthanawiboon","sequence":"additional","affiliation":[{"name":"Khon Kaen University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6163-3740","authenticated-orcid":false,"given":"Malinee","family":"Thanee","sequence":"additional","affiliation":[{"name":"Khon Kaen University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4731-9556","authenticated-orcid":false,"given":"Kanin","family":"Salao","sequence":"additional","affiliation":[{"name":"National University of Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patcharaporn","family":"Tippayawat","sequence":"additional","affiliation":[{"name":"Khon Kaen University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2770-7415","authenticated-orcid":false,"given":"Chanvit","family":"Leelayuwat","sequence":"additional","affiliation":[{"name":"Khon Kaen University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nisa","family":"Chuangchot","sequence":"additional","affiliation":[{"name":"Mahidol University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7681-4295","authenticated-orcid":false,"given":"Auttawit","family":"Sirichoat","sequence":"additional","affiliation":[{"name":"Khon Kaen University"},{"name":"Khon Kaen University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5617-8746","authenticated-orcid":false,"given":"Arnone","family":"Nithichanon","sequence":"additional","affiliation":[{"name":"Khon Kaen University"},{"name":"Khon Kaen University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6410-0391","authenticated-orcid":false,"given":"Chatcharin","family":"Kamsom","sequence":"additional","affiliation":[{"name":"Khon Kaen University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saitharn","family":"Papalee","sequence":"additional","affiliation":[{"name":"Khon Kaen University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chalida","family":"Chuenchom","sequence":"additional","affiliation":[{"name":"Khon Kaen University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8866-9459","authenticated-orcid":false,"given":"Wisitsak","family":"Phoksawat","sequence":"additional","affiliation":[{"name":"Khon Kaen University"},{"name":"Khon Kaen University"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,1,23]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.01960"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11357-010-9200-6"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2020.04.003"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1515\/biol-2022-0557"},{"issue":"5","key":"e_1_3_3_6_2","first-page":"595","article-title":"T cell ageing: Effects of age on development, survival & function","volume":"138","author":"Salam N","year":"2013","unstructured":"Salam N, Rane S, Das R, et al. 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