{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T07:55:10Z","timestamp":1777881310676,"version":"3.51.4"},"reference-count":25,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ophthalmol Eye Dis"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>To evaluate the corneal effects of the intravitreal dexamethasone implantation using corneal topography and specular microscopy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and methods:<\/jats:title>\n                    <jats:p>27 eyes of the 27 patients who received a single intravitreal dexamethasone implantation dose for diabetic macular edema were enrolled in this study. Sirius topography and EM-3000 specular microscopic examinations were performed at the initial examination (baseline), and then on the first day, during the first week, and 1\u2009month after IDI. Changes in corneal parameters were investigated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The mean age was 58.66\u2009\u00b1\u20096.59\u2009years. 15 patients were men, and 12 were women. The mean disease duration was 12.2\u2009\u00b1\u20092.4\u2009months, and mean glycosylated hemoglobin (HbA1c) was 7.2\u2009\u00b1\u20091.1. After dexamethasone injection, the mean central corneal thickness, endothelial cell density, and coefficient variation of cell area presented a statistically significant decrease ( p\u2009&lt;\u20090.05). Anterior segment parameters, such as anterior chamber depth, iridocorneal angle, sim K1 and K2 keratometry, pupillary diameter, horizontal visible iris diameter, and corneal astigmatism did not change ( p\u2009&gt;\u20090.05).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Intravitreal dexamethasone implantation affects corneal endothelial cell structure but does not appear to affect corneal topography parameters.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/2515841420947544","type":"journal-article","created":{"date-parts":[[2020,8,6]],"date-time":"2020-08-06T11:09:21Z","timestamp":1596712161000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["The corneal effects of intravitreal dexamethasone implantation"],"prefix":"10.1177","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1827-968X","authenticated-orcid":false,"given":"Alper Halil","family":"Bayat","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Esenler Hospital, Medipol University, APT: 5 Bahceler, AVE Esenler, Istanbul 34250, Turkey"},{"name":"Department of Ophthalmology, Alanya Life Hospital, Antalya, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gamze","family":"Karata\u015f","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Okmeydan\u0131 Research &Traning Hospital, University of Health Sciences, \u0130stanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammet Mustafa","family":"Kurt","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Samsun Gazi State Hospital, Samsun, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mustafa Nuri","family":"El\u00e7io\u011flu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Okmeydan\u0131 Research &Traning Hospital, University of Health Sciences, \u0130stanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,8,6]]},"reference":[{"key":"bibr1-2515841420947544","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-011-0019-z"},{"key":"bibr2-2515841420947544","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2010.03.032"},{"key":"bibr3-2515841420947544","doi-asserted-by":"publisher","DOI":"10.3109\/15569527.2014.975242"},{"key":"bibr4-2515841420947544","doi-asserted-by":"publisher","DOI":"10.1080\/09273940600732380"},{"key":"bibr5-2515841420947544","first-page":"245","volume":"24","author":"Jamil AZ","year":"2014","journal-title":"J Coll Physicians Surg 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