{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T07:55:33Z","timestamp":1777881333301,"version":"3.51.4"},"reference-count":31,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ophthalmol Eye Dis"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Corneal collagen cross-linking (CXL) is considered an effective procedure for slowing down or eliminating the progression of keratoconus. New techniques, in combination with CXL, have been proposed to stop the evolution of keratoconus and improve the visual function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To evaluate the effectiveness of combined photorefractive keratectomy (PRK) with mitomycin-C (MMC) application and CXL in the management of grade 1\u20132 keratoconus over a 2-year follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Fifteen eyes underwent topography-guided PRK with 0.02% MMC application immediately followed by standard CXL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Best corrected visual acuity improved from 0.15\u2009\u00b1\u20090.11 logMAR to 0.08\u2009\u00b1\u20090.09 logMAR at 24 months ( p\u2009&lt;\u20090.0001) in treated eyes. Mean steepest meridian keratometry reduced from 48.79\u2009\u00b1\u20093.22\u2009D at baseline to 46.16\u2009\u00b1\u20093.11\u2009D at 24 months ( p\u2009&lt;\u20090.0001). Mean flattest meridian keratometry reduced from 45.18\u2009\u00b1\u20092.17\u2009D preoperatively to 44.35\u2009\u00b1\u20092.19\u2009D at 24 months ( p\u2009&lt;\u20090.0001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Simultaneous topography-guided PRK with MMC 0.02% application and standard CXL is a safe, promising and effective procedure in the treatment of mild and moderate keratoconus.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/25158414221083362","type":"journal-article","created":{"date-parts":[[2022,3,23]],"date-time":"2022-03-23T09:18:12Z","timestamp":1648027092000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Combined photorefractive keratectomy and corneal collagen cross-linking for treatment of keratoconus: a 2-year follow-up study"],"prefix":"10.1177","volume":"14","author":[{"given":"Giuseppe","family":"De Rosa","sequence":"first","affiliation":[{"name":"Eye Clinic, Multidisciplinary Department of Medical, Surgical and Dental Sciences, University of Campania \u2018Luigi Vanvitelli\u2019, Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Settimio","family":"Rossi","sequence":"additional","affiliation":[{"name":"Eye Clinic, Multidisciplinary Department of Medical, Surgical and Dental Sciences, University of Campania \u2018Luigi Vanvitelli\u2019, Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmine","family":"Santamaria","sequence":"additional","affiliation":[{"name":"Eye Clinic, Multidisciplinary Department of Medical, Surgical and Dental Sciences, University of Campania \u2018Luigi Vanvitelli\u2019, Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosa","family":"Boccia","sequence":"additional","affiliation":[{"name":"Eye Clinic, Multidisciplinary Department of Medical, Surgical and Dental Sciences, University of Campania \u2018Luigi Vanvitelli\u2019, Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigi","family":"De Rosa","sequence":"additional","affiliation":[{"name":"Eye Clinic, Multidisciplinary Department of Medical, Surgical and Dental Sciences, University of Campania \u2018Luigi Vanvitelli\u2019, Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4248-4376","authenticated-orcid":false,"given":"Francesco Maria","family":"D\u2019Alterio","sequence":"additional","affiliation":[{"name":"Eye Clinic, Multidisciplinary Department of Medical, Surgical and Dental Sciences, University of Campania \u2018Luigi Vanvitelli\u2019, Via Sergio Pansini 5, 80131 Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Simonelli","sequence":"additional","affiliation":[{"name":"Eye Clinic, Multidisciplinary Department of Medical, Surgical and Dental Sciences, University of Campania \u2018Luigi Vanvitelli\u2019, Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,3,23]]},"reference":[{"key":"bibr1-25158414221083362","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2017.06.009"},{"key":"bibr2-25158414221083362","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e318074e424"},{"key":"bibr3-25158414221083362","doi-asserted-by":"publisher","DOI":"10.3928\/1081597X-20090813-10"},{"key":"bibr4-25158414221083362","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(02)02220-1"},{"key":"bibr5-25158414221083362","doi-asserted-by":"publisher","DOI":"10.2174\/1874364101711010262"},{"key":"bibr6-25158414221083362","doi-asserted-by":"publisher","DOI":"10.1007\/s10792-017-0772-3"},{"key":"bibr7-25158414221083362","doi-asserted-by":"publisher","DOI":"10.3928\/1081-597X-20030901-06"},{"key":"bibr8-25158414221083362","doi-asserted-by":"publisher","DOI":"10.1016\/j.optom.2013.12.002"},{"key":"bibr9-25158414221083362","doi-asserted-by":"publisher","DOI":"10.4103\/0301-4738.116067"},{"key":"bibr10-25158414221083362","doi-asserted-by":"publisher","DOI":"10.3928\/1081597X-20121005-06"},{"key":"bibr11-25158414221083362","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2006.09.012"},{"key":"bibr12-25158414221083362","doi-asserted-by":"publisher","DOI":"10.3928\/1081597X-20101223-02"},{"key":"bibr13-25158414221083362","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2012.07.004"},{"key":"bibr14-25158414221083362","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(99)00019-6"},{"key":"bibr15-25158414221083362","first-page":"42","volume":"55","author":"Hashemi H","year":"2017","journal-title":"Acta Med Iran"},{"key":"bibr16-25158414221083362","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S188517"},{"key":"bibr17-25158414221083362","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e31821e429d"},{"key":"bibr18-25158414221083362","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1990.01070070051034"},{"key":"bibr19-25158414221083362","doi-asserted-by":"publisher","DOI":"10.3928\/1081597X-20090813-09"},{"key":"bibr20-25158414221083362","doi-asserted-by":"publisher","DOI":"10.1111\/aos.13986"},{"key":"bibr21-25158414221083362","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S140627"},{"key":"bibr22-25158414221083362","doi-asserted-by":"publisher","DOI":"10.1159\/000480242"},{"key":"bibr23-25158414221083362","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/321953"},{"key":"bibr24-25158414221083362","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2016.01.010"},{"key":"bibr25-25158414221083362","doi-asserted-by":"publisher","DOI":"10.3928\/1081597X-20100121-10"},{"key":"bibr26-25158414221083362","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2011.04.033"},{"key":"bibr27-25158414221083362","doi-asserted-by":"publisher","DOI":"10.2174\/1874364101307010063"},{"key":"bibr28-25158414221083362","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2020.108218"},{"key":"bibr29-25158414221083362","doi-asserted-by":"publisher","DOI":"10.3928\/1081597X-20201124-01"},{"key":"bibr30-25158414221083362","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2013.12.017"},{"key":"bibr31-25158414221083362","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0000000000001663"}],"container-title":["Therapeutic Advances in Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/25158414221083362","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/25158414221083362","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/25158414221083362","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:40:03Z","timestamp":1777596003000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/25158414221083362"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":31,"alternative-id":["10.1177\/25158414221083362"],"URL":"https:\/\/doi.org\/10.1177\/25158414221083362","relation":{},"ISSN":["2515-8414","2515-8414"],"issn-type":[{"value":"2515-8414","type":"print"},{"value":"2515-8414","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1]]},"article-number":"25158414221083362"}}