{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T21:22:03Z","timestamp":1784236923994,"version":"3.55.0"},"reference-count":0,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,3,30]],"date-time":"2025-03-30T00:00:00Z","timestamp":1743292800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,3,30]],"date-time":"2025-03-30T00:00:00Z","timestamp":1743292800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100004328","name":"Genentech","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004328","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ophthalmol Eye Dis"],"published-print":{"date-parts":[[2025,11]]},"abstract":"\n What is this summary about?<\/jats:bold>\n <\/jats:p>\n \n This is the summary of an article published in\n Ophthalmology Retina<\/jats:italic>\n . This summary presents results from a study that used information from a United States (US) healthcare database to look at how\n intravitreal<\/jats:bold>\n injections (injections into the eyeball) of anti-\n vascular endothelial growth factor<\/jats:bold>\n (anti-VEGF) may affect vision for patients with either\n neovascular age-related macular degeneration (nAMD) or diabetic macular edema (DME)<\/jats:bold>\n . The study focused on maintaining driving vision over 4\u2009years.\n <\/jats:p>\n \n What happened in this study?<\/jats:bold>\n <\/jats:p>\n \n Researchers looked at information in the Vestrum Health database to identify patients diagnosed with\n nAMD<\/jats:bold>\n or\n DME<\/jats:bold>\n between January 1, 2014 and June 30, 2019 and had medical records that showed how their vision changed while they were receiving anti-\n VEGF<\/jats:bold>\n treatment.\n <\/jats:p>\n \n What were the results?<\/jats:bold>\n <\/jats:p>\n \n Vision improved for both\n nAMD<\/jats:bold>\n and\n DME<\/jats:bold>\n patient groups in the first year of anti-\n VEGF<\/jats:bold>\n treatment but then got worse over the next 3\u2009years. Patients with\n nAMD<\/jats:bold>\n or\n DME<\/jats:bold>\n who had more anti-\n VEGF<\/jats:bold>\n injections in the first year of treatment had a higher chance of maintaining their driving vision. Both groups of patients were more likely to lose their driving vision if they were older or had worse vision before starting treatment.\n <\/jats:p>\n \n What do the results mean?<\/jats:bold>\n <\/jats:p>\n \n These results show that starting anti-\n VEGF<\/jats:bold>\n treatment early and having frequent injections is important for keeping driving vision in patients with\n nAMD<\/jats:bold>\n or\n DME<\/jats:bold>\n . Currently, patients with\n nAMD<\/jats:bold>\n or\n DME<\/jats:bold>\n may not be getting injections early and often enough to maintain their driving vision over the long term.\n <\/jats:p>\n \n Where can I find the original article on which this summary is based?<\/jats:bold>\n <\/jats:p>\n \n You can read the original article published in the journal\n Ophthalmology Retina<\/jats:italic>\n at:\n https:\/\/doi.org\/10.1016\/j.oret.2023.10.010<\/jats:ext-link>\n <\/jats:p>\n \n Who is this article for?<\/jats:bold>\n <\/jats:p>\n \n The purpose of this plain language summary is to help patients with either\n nAMD<\/jats:bold>\n or\n DME<\/jats:bold>\n , their caregivers, patient advocates, healthcare professionals, insurance providers, and policy makers better understand the results of this study.\n <\/jats:p>\n \n When was this plain language summary of publication written?<\/jats:bold>\n <\/jats:p>\n This summary was drafted in December 2023.<\/jats:p>\n \n Neovascular age-related macular degeneration (nAMD) and diabetic macular edema (DME)<\/jats:bold>\n are among the leading causes of vision loss among individuals aged 50\u2009years and older in the US and worldwide\n <\/jats:p>","DOI":"10.1177\/25158414241310274","type":"journal-article","created":{"date-parts":[[2025,3,31]],"date-time":"2025-03-31T00:19:33Z","timestamp":1743380373000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Maintaining driving vision after intravitreal anti-VEGF therapy in patients with neovascular AMD and diabetic macular edema: a plain language summary of publication"],"prefix":"10.1177","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4494-7517","authenticated-orcid":false,"given":"Parisa","family":"Emami-Naeini","sequence":"first","affiliation":[{"name":"Department of Ophthalmology and Vision Science, University of California, Davis, Sacramento, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Garmo","sequence":"additional","affiliation":[{"name":"Genentech, Inc., South San Francisco, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3657-575X","authenticated-orcid":false,"given":"Nick","family":"Boucher","sequence":"additional","affiliation":[{"name":"Vestrum Health, Ottawa, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-3627-0833","authenticated-orcid":false,"given":"Rusirini","family":"Fernando","sequence":"additional","affiliation":[{"name":"Vestrum Health, Ottawa, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia","family":"Menezes","sequence":"additional","affiliation":[{"name":"Genentech, Inc., South San Francisco, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,3,30]]},"container-title":["Therapeutic Advances in Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/25158414241310274","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/25158414241310274","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/25158414241310274","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:40:39Z","timestamp":1777596039000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/25158414241310274"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,30]]},"references-count":0,"alternative-id":["10.1177\/25158414241310274"],"URL":"https:\/\/doi.org\/10.1177\/25158414241310274","relation":{},"ISSN":["2515-8414","2515-8414"],"issn-type":[{"value":"2515-8414","type":"print"},{"value":"2515-8414","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,30]]},"article-number":"25158414241310274"}}