{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T07:55:59Z","timestamp":1777881359305,"version":"3.51.4"},"reference-count":29,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T00:00:00Z","timestamp":1747612800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T00:00:00Z","timestamp":1747612800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Miriam Hospital Foundation"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ophthalmol Eye Dis"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Cardiovascular disease increases the risk for cerebrovascular disease (CBVD) and cognitive decline. The retina has become an ideal target for imaging cerebrovascular changes via optical coherence tomography angiography (OCTA). Whether OCTA metrics map onto clinical outcomes in adults at high risk for CBVD and cognitive decline remains unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>This study examined the relationship between OCTA metrics and domain-specific cognition in older adults recently discharged from a 12-week cardiac rehabilitation program, who are at high risk of both CBVD and cognitive decline.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>This was a prospective, feasibility\/pilot study to determine whether OCTA metrics are related to cognition in this unique population of high-risk adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Twenty-two older adults recruited within 3\u2009months of completing a 12-week cardiac rehabilitation program participated in a single visit consisting of cognitive assessment and OCTA imaging. Cardiac\/exercise metrics were compared pre- and post-rehabilitation. Primary outcomes were analyzed using partial correlation, and multiple regression assessed whether exercise moderates the relationship between retinal vasculature and cognition.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Higher performance in episodic memory predicted retinal vascular perfusion. Change in time spent performing exercise and change in systolic blood pressure from pre- to post-cardiac rehabilitation were associated with higher logical memory performance post-rehab. Exercise did not moderate the relationship between retinal vascular perfusion and cognition.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The results of this study support a direct relationship between retinal vascular integrity and cognition in those at high risk for cognitive impairment and cardiovascular disease (CVD). Future research in larger samples with data collection both pre- and post-cardiac rehabilitation will inform whether this relationship is mediated by exercise.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/25158414251340541","type":"journal-article","created":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T06:55:21Z","timestamp":1747724121000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Pilot study examining the relationship between retinal vasculature and cognition in older adults recently discharged from a 12-week cardiac rehabilitation program"],"prefix":"10.1177","volume":"17","author":[{"given":"Jordan","family":"Sergio","sequence":"first","affiliation":[{"name":"Interdisciplinary Neuroscience Program, University of Rhode Island, Kingston, RI, USA"},{"name":"Ryan Institute for Neuroscience, University of Rhode Island, Kingston, RI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emma","family":"Gosselin","sequence":"additional","affiliation":[{"name":"Mental Health Department, Manchester VA Medical Center, Manchester, NH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edmund","family":"Arthur","sequence":"additional","affiliation":[{"name":"School of Optometry, University of Alabama at Birmingham, Birmingham, AL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-Chih","family":"Wu","sequence":"additional","affiliation":[{"name":"The Miriam Hospital Cardiovascular Rehabilitation Center, Lifespan Cardiovascular Institute \u2013 Lifespan, Providence, RI, USA"},{"name":"Center of Innovation for Long Term Services &amp; Support, Providence VA Healthcare System \u2013 Providence, RI, USA"},{"name":"Department of Medicine, Alpert Medical School &amp; Department of Epidemiology, School of Public Health, Brown University \u2013 Brown, Providence, RI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5090-4206","authenticated-orcid":false,"given":"Jessica","family":"Alber","sequence":"additional","affiliation":[{"name":"Interdisciplinary Neuroscience Program, University of Rhode Island, Kingston, RI, USA"},{"name":"Ryan Institute for Neuroscience, University of Rhode Island, Kingston, RI, USA"},{"name":"Butler Hospital Memory and Aging Program, Providence, RI, USA"},{"name":"Department of Biomedical and Pharmaceutical Sciences, University of Rhode Island, 130 Flagg Road, Kingston, RI 02881, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,5,19]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.dadm.2018.01.003"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcha.2018.04.006"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-021-00611-7"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2022.854158"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/WAD.0000000000000410"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jshs.2023.04.003"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202406631"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/aos.14419"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2020.09.017"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11357-014-9650-3"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/HCR.0000000000000348"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1497.2001.016009606.x"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.166.10.1092"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005650-199206000-00002"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12006"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.18-25294"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-95230-0"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1080\/13803395.2011.643227"},{"key":"e_1_3_4_20_2","first-page":"1997","volume-title":"Wechsler Memory Scale","author":"Wechsler D.","unstructured":"Wechsler D. Wechsler Memory Scale, 3rd ed. San Antonio, TX: Psychological Corporation, 1997.","edition":"3"},{"key":"e_1_3_4_21_2","volume-title":"Neurosensory center comprehensive examination for aphasia","author":"Spreen O","year":"1977","unstructured":"Spreen O, Benton AL. Neurosensory center comprehensive examination for aphasia. Victoria, BC: University of Victoria, Neuropsychology Laboratory, 1977."},{"key":"e_1_3_4_22_2","volume-title":"Wechsler Adult Intelligence Scale","author":"Wechsler D.","year":"2008","unstructured":"Wechsler D. Wechsler Adult Intelligence Scale, 4th ed. Bloomington, MN: PsychCorp, an imprint of Pearson Clinical Assessment, 2008.","edition":"4"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/1099-1166(200006)15:6<548::AID-GPS242>3.0.CO;2-U"},{"issue":"1","key":"e_1_3_4_24_2","first-page":"169","article-title":"Nonvascular retinal imaging markers of preclinical Alzheimer\u2019s disease","volume":"4","author":"Snyder PJ","year":"2016","unstructured":"Snyder PJ, Johnson LN, Lim YY, et al. Nonvascular retinal imaging markers of preclinical Alzheimer\u2019s disease. Alzheimers Dement 2016; 4(1): 169\u2013178.","journal-title":"Alzheimers Dement"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.2174\/1745017902117010075"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/gps.4220"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm8030294"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2014.803"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2020.112488"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjsports-2021-104981"}],"container-title":["Therapeutic Advances in Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/25158414251340541","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/25158414251340541","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/25158414251340541","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:40:43Z","timestamp":1777596043000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/25158414251340541"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,19]]},"references-count":29,"alternative-id":["10.1177\/25158414251340541"],"URL":"https:\/\/doi.org\/10.1177\/25158414251340541","relation":{},"ISSN":["2515-8414","2515-8414"],"issn-type":[{"value":"2515-8414","type":"print"},{"value":"2515-8414","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,19]]},"article-number":"25158414251340541"}}