{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T07:56:00Z","timestamp":1777881360851,"version":"3.51.4"},"reference-count":55,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,6,28]],"date-time":"2025-06-28T00:00:00Z","timestamp":1751068800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,6,28]],"date-time":"2025-06-28T00:00:00Z","timestamp":1751068800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ophthalmol Eye Dis"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:p>Corneal crosslinking (CXL) was first introduced in clinical practice in 2003. Since then, this procedure has been established as the first-line treatment in the management of progressive keratoconus. Over the last years, many different protocols have emerged, each one of them with variable clinical outcomes and safety profile. Progression of keratoconus after primary CXL is very rare, but it has been reported in the literature. This review summarises the existing data on repeated CXL after primary failure, emphasising on clinical efficacy and safety.<\/jats:p>","DOI":"10.1177\/25158414251350071","type":"journal-article","created":{"date-parts":[[2025,6,28]],"date-time":"2025-06-28T07:37:21Z","timestamp":1751096241000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Repeated corneal crosslinking for progressive keratoconus: efficiency and safety"],"prefix":"10.1177","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4283-5260","authenticated-orcid":false,"given":"Eleftherios","family":"Chatzimichail","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, University Hospital of Basel, Basel, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-1844-1949","authenticated-orcid":false,"given":"Georgios","family":"Chondrozoumakis","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University Hospital of Heraklion, Heraklion, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farideh","family":"Doroodgar","sequence":"additional","affiliation":[{"name":"Translational Ophthalmology Research Center, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9833-2200","authenticated-orcid":false,"given":"Efstathios","family":"Vounotrypidis","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Ulm University, Ulm, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georgios D.","family":"Panos","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece"},{"name":"Division of Ophthalmology &amp; Visual Sciences, School of Medicine, University of Nottingham, Nottingham, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolas","family":"Feltgen","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University Hospital of Basel, Basel, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zisis","family":"Gatzioufas","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University Hospital of Basel, Mittlerestrasse 91, Basel, 4031, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,6,28]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(02)02220-1"},{"issue":"105","key":"e_1_3_4_3_2","article-title":"Three different protocols of corneal collagen crosslinking in keratoconus: conventional, accelerated and iontophoresis","author":"Bouheraoua N","year":"2015","unstructured":"Bouheraoua N, Jouve L, Borderie V, et al. Three different protocols of corneal collagen crosslinking in keratoconus: conventional, accelerated and iontophoresis. JoVE (Journal of Visualized Experiments) 2015; (105): e53119.","journal-title":"JoVE (Journal of Visualized Experiments)"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2015.02.005"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S409178"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2016.02.029"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1080\/08820538.2019.1659832"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/ICU.0000000000000967"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.3928\/1081597X-20180426-01"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0000000000001707"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2014.06.030"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40662-021-00240-8"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.3928\/1081597X-20140903-03"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/690961"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2023.01.022"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0000000000002128"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41433-020-01365-1"},{"key":"e_1_3_4_18_2","article-title":"Repeat corneal collagen cross-linking after failure of primary cross-linking in keratoconus","author":"Maskill D","year":"2023","unstructured":"Maskill D, Okonkwo A, Onsiong C, et al. Repeat corneal collagen cross-linking after failure of primary cross-linking in keratoconus. Br J Ophthalmol 2023; bjo-2023-323391.","journal-title":"Br J Ophthalmol"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0000000000003165"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10792-023-02715-0"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1177\/1120672120945662"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0000000000001505"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2013.10.028"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2015.08.023"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1167\/tvst.10.5.13"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2014.09.033"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2009.03.035"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.4103\/ijo.IJO_1595_21"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0000000000001736"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1080\/08820538.2021.1893762"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1097\/APO.0000000000000333"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.1177\/11206721221099257"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2012.10.023"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.1111\/aos.13060"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e3181915943"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e318030df5a"},{"key":"e_1_3_4_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2009.06.031"},{"key":"e_1_3_4_38_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.13-12576"},{"key":"e_1_3_4_39_2","doi-asserted-by":"publisher","DOI":"10.1111\/opo.12032"},{"key":"e_1_3_4_40_2","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0000000000001685"},{"key":"e_1_3_4_41_2","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0000000000000064"},{"key":"e_1_3_4_42_2","doi-asserted-by":"publisher","DOI":"10.3928\/1081597X-20210830-01"},{"key":"e_1_3_4_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2013.03.026"},{"key":"e_1_3_4_44_2","doi-asserted-by":"publisher","DOI":"10.1080\/02713683.2022.2117383"},{"key":"e_1_3_4_45_2","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e318198384f"},{"key":"e_1_3_4_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2008.02.036"},{"key":"e_1_3_4_47_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2022.787167"},{"key":"e_1_3_4_48_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40662-021-00256-0"},{"key":"e_1_3_4_49_2","doi-asserted-by":"crossref","unstructured":"Shajari M Kolb CM Agha B et al. Comparison of standard and accelerated corneal cross-linking for the treatment of keratoconus: a meta-analysis. Acta Ophthalmologica 2019; 97(1): 22\u201335. https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aos.13814","DOI":"10.1111\/aos.13814"},{"key":"e_1_3_4_50_2","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0000000000002092"},{"key":"e_1_3_4_51_2","doi-asserted-by":"publisher","DOI":"10.1080\/17469899.2019.1611425"},{"key":"e_1_3_4_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2005.12.092"},{"key":"e_1_3_4_53_2","doi-asserted-by":"publisher","DOI":"10.3928\/1081597X-20161006-02"},{"key":"e_1_3_4_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2022.109363"},{"key":"e_1_3_4_55_2","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S409009"},{"key":"e_1_3_4_56_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-023-06287-8"}],"container-title":["Therapeutic Advances in Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/25158414251350071","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/25158414251350071","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/25158414251350071","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:40:47Z","timestamp":1777596047000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/25158414251350071"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,28]]},"references-count":55,"alternative-id":["10.1177\/25158414251350071"],"URL":"https:\/\/doi.org\/10.1177\/25158414251350071","relation":{},"ISSN":["2515-8414","2515-8414"],"issn-type":[{"value":"2515-8414","type":"print"},{"value":"2515-8414","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,28]]},"article-number":"25158414251350071"}}