{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T22:47:05Z","timestamp":1790376425253,"version":"4.1.0"},"reference-count":21,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,6,21]],"date-time":"2025-06-21T00:00:00Z","timestamp":1750464000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,6,21]],"date-time":"2025-06-21T00:00:00Z","timestamp":1750464000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ophthalmol Eye Dis"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Epiretinal membrane (ERM) formation following a successful rhegmatogenous retinal detachment (RRD) operation has been reported to occur in about 4%\u201315% of the cases. In this study, we collected vitreous samples from patients with RRD to identify whether the concentration of IL-6 is correlated with the presence of postoperative ERM. We aim is to identify whether the inflammatory cascade could be a potential key factor in the ERM pathogenesis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This was a prospective single-centre study where 42 eyes were enrolled. All patients underwent 25G PPV. The vitreous sample was collected before the infusion line was opened so that the sample would not be diluted. Then, the sample was centrifuged at 5000\u2009g for 15\u2009min at 15\u00b0C. Afterwards, the supernatant fluid was transferred to an Eppendorf tube and stored at \u221240\u00b0C. Electrochemiluminescence immunoassay (ECLIA) was employed for the measurement of IL-6 concentration (pg\/ml). All patients had optical coherence tomography (OCT) scans at the macula at 4\u2009weeks, 3\u2009months and 1\u2009year after primary RRD repair to identify the presence of the ERM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      All patients had a follow-up of at least 12\u2009months. The mean BCVA of all 42 eyes at the end of follow-up period was 0.24\u2009\u00b1\u20090.31\u2009LogMar. The presence of ERM was identified in 28.6% (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200912) of the patients, and the mean IL-6 concentration was 573.96\u2009\u00b1\u20091179.58\u2009pg\/ml. It appears that the patients who developed a post op ERM had an IL-6 mean concentration value of 173.96\u2009\u00b1\u2009191.25 pg\/ml, and the patients with no post op ERM had 733.97\u2009\u00b1\u20091364.04\u2009pg\/ml with\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      -value\u2009=\u20090.04\u2009&lt;\u20090.05. Nevertheless, following a multivariate binary logistic regression model, the above results did not appear to be statistically significant.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>High concentration of IL-6 in the vitreous of eyes with RRD does not hold a significant role in the ERM pathogenesis. Our study identified the presence of a draining retinotomy as the most significant risk factor for ERM formation following a successful surgical RRD repair.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/25158414251350072","type":"journal-article","created":{"date-parts":[[2025,6,21]],"date-time":"2025-06-21T05:25:46Z","timestamp":1750483546000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Correlation of intravitreal IL-6 with the formation of epiretinal membrane after successful retinal detachment repair"],"prefix":"10.1177","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6057-3420","authenticated-orcid":false,"given":"Konstantinos","family":"Ananikas","sequence":"first","affiliation":[{"name":"St Paul\u2019s Eye Department, Royal Liverpool University Hospital Liverpool, W Derby St, Liverpool, L7 8YA, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0570-6438","authenticated-orcid":false,"given":"Panagiotis","family":"Stavrakas","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, School of Medicine, University of Patras, Patras, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5876-2599","authenticated-orcid":false,"given":"Christos","family":"Kroupis","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, Attikon University General Hospital, National and Kapodistrian University of Athens"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7959-4854","authenticated-orcid":false,"given":"Evita Evangelia","family":"Christou","sequence":"additional","affiliation":[{"name":"Oxford Eye Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stratos V.","family":"Gotzaridis","sequence":"additional","affiliation":[{"name":"My Retina Athens Eye Center, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9303-2161","authenticated-orcid":false,"given":"Panagiotis","family":"Dervenis","sequence":"additional","affiliation":[{"name":"Ophthalmology Department, Colchester Eye Centre of Excellence, East Suffolk and North Essex NHS Foundation Trust, Tyrnavos, Thessaly, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios","family":"Papaconstantinou","sequence":"additional","affiliation":[{"name":"1st Department of Ophthalmology, \u201cG. Gennimatas\u201d General Hospital of Athens, University of Athens, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,6,21]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1982.01030030291012"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1159\/000355077"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.09-4439"},{"issue":"1","key":"e_1_3_4_5_2","first-page":"25","article-title":"Risk factors for epiretinal membrane surgery after initial pars plana vitrectomy for rhegmatogenous retinal detachment","volume":"8","author":"Takamidou Y","year":"2022","unstructured":"Takamidou Y, Mizuguchi T, Sakurai R, et al. Risk factors for epiretinal membrane surgery after initial pars plana vitrectomy for rhegmatogenous retinal detachment. Fujita Med J 2022; 8(1): 25\u201330.","journal-title":"Fujita Med J"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.18240\/ijo.2019.12.09"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1159\/000525530"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a016295"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1080\/09273948.2016.1277247"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(01)01125-4"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2016.12.006"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000186784.62662.A1"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2021.07.028"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.3928\/23258160-20230307-01"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.18240\/ijo.2023.07.16"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1159\/000529451"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e318162b031"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e318242b965"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2012.11.010"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/glia.22942"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.16-20657"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-97738-x"}],"container-title":["Therapeutic Advances in Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/25158414251350072","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/25158414251350072","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/25158414251350072","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:40:47Z","timestamp":1777596047000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/25158414251350072"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,21]]},"references-count":21,"alternative-id":["10.1177\/25158414251350072"],"URL":"https:\/\/doi.org\/10.1177\/25158414251350072","relation":{},"ISSN":["2515-8414","2515-8414"],"issn-type":[{"value":"2515-8414","type":"print"},{"value":"2515-8414","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,21]]},"article-number":"25158414251350072"}}