{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T07:56:05Z","timestamp":1777881365649,"version":"3.51.4"},"reference-count":18,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Azura Ophthalmics","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ophthalmol Eye Dis"],"published-print":{"date-parts":[[2026,1]]},"abstract":"\n Demodex<\/jats:italic>\n blepharitis is a chronic, progressive condition characterized by inflammation, ocular irritation, and erythema due to an overgrowth of mites in hair follicles and oil glands of the eyelids. AZR-MD-001(AZR) is a selenium sulfide-containing ophthalmic ointment that is a potential treatment option for\n Demodex<\/jats:italic>\n blepharitis. We wished to complete a case study to identify the potential of this agent to treat\n Demodex<\/jats:italic>\n blepharitis. A patient with chronic\n Demodex<\/jats:italic>\n blepharitis applied AZR 0.5% to the right lower eyelid every other day at bedtime for 6\u2009weeks, discontinued treatment for 6\u2009weeks, then treated the left lower eyelid with vehicle only for 6\u2009weeks, followed by use of AZR 0.5% for both lower eyelids twice a week for 6\u2009weeks. Eyelashes were removed and pooled for evidence of mites and collarettes before and after the first treatment, and eyes were inspected for signs of blepharitis before and after each treatment period. After treatment with AZR 0.5%, resolution of blepharitis occurred in the treated eye, with no evidence of\n Demodex<\/jats:italic>\n mites. The untreated eye showed no difference from baseline. After discontinuing for 6\u2009weeks, the signs of blepharitis returned, similar to baseline. After 6\u2009weeks of vehicle application to the left eye, no changes in signs were observed. After treatment with AZR 0.5% for 6\u2009weeks to both eyes, complete resolution of blepharitis occurred in both eyes. No adverse events were reported. Treatment with AZR 0.5% was efficacious in eradicating\n Demodex<\/jats:italic>\n blepharitis, which was not evidenced when using vehicle or a lack of treatment. This demonstrated a potential new use for AZR to treat\n Demodex<\/jats:italic>\n blepharitis. Further studies are required to establish the safety and efficacy of this product.\n <\/jats:p>","DOI":"10.1177\/25158414251405397","type":"journal-article","created":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T07:23:36Z","timestamp":1767597816000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Demodex<\/i>\n blepharitis treatment with a selenium sulfide-containing ointment: a case report"],"prefix":"10.1177","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-2042-6134","authenticated-orcid":false,"given":"Yair","family":"Alster","sequence":"first","affiliation":[{"name":"Azura Ophthalmics Ltd, 5 Druyanov Street, Tel Aviv 6314305, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omer","family":"Rafaeli","sequence":"additional","affiliation":[{"name":"Azura Ophthalmics Ltd, Tel Aviv, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles","family":"Bosworth","sequence":"additional","affiliation":[{"name":"Azura Ophthalmics Ltd, Tel Aviv, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,1,4]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1515\/ap-2016-0112"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/j.jcrs.0000000000001619"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S440199"},{"key":"e_1_3_4_5_2","first-page":"635","article-title":"[Chronic blepharitis and Demodex]","volume":"80","author":"Rodriguez AE","year":"2005","unstructured":"Rodriguez AE, Ferrer C, Alio JL. [Chronic blepharitis and Demodex]. Arch Soc Esp Oftalmol 2005; 80: 635\u2013642.","journal-title":"Arch Soc Esp Oftalmol"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.13-13166"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.10-6997c"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-195408000-00008"},{"key":"e_1_3_4_9_2","first-page":"173","article-title":"Seborrheic blepharitis","volume":"52","author":"Thygeson P","year":"1954","unstructured":"Thygeson P, Vaughan DGJr. Seborrheic blepharitis. Trans Am Ophthalmol Soc 1954; 52: 173\u2013188.","journal-title":"Trans Am Ophthalmol Soc"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(54)90708-4"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1956.00930030250011"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(60)92060-2"},{"key":"e_1_3_4_13_2","unstructured":"Pharmaceuticals T. XDEMVY (lotilaner ophthalmic solution) 0.25%. Irvine CA USA2023."},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2023.05.030"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtos.2024.11.008"},{"key":"e_1_3_4_16_2","first-page":"1298","article-title":"The in vitro effect of various selenium disulfide concentrations on demodex folliculorum","volume":"62","author":"Heczko J","year":"2021","unstructured":"Heczko J, Schell C, Pansick A, et al. The in vitro effect of various selenium disulfide concentrations on demodex folliculorum. Investig Ophthalmol Visual Sci 2021; 62: 1298\u20131298.","journal-title":"Investig Ophthalmol Visual Sci"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.3389\/fpls.2023.1102594"},{"key":"e_1_3_4_18_2","first-page":"262","article-title":"Selenium as a protective agent against pests: a review","volume":"8","author":"Mechora S","year":"2019","unstructured":"Mechora S. Selenium as a protective agent against pests: a review. Plants (Basel) 2019; 8: 262.","journal-title":"Plants (Basel)"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtos.2023.07.002"}],"container-title":["Therapeutic Advances in Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/25158414251405397","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/25158414251405397","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/25158414251405397","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:40:59Z","timestamp":1777596059000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/25158414251405397"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":18,"alternative-id":["10.1177\/25158414251405397"],"URL":"https:\/\/doi.org\/10.1177\/25158414251405397","relation":{},"ISSN":["2515-8414","2515-8414"],"issn-type":[{"value":"2515-8414","type":"print"},{"value":"2515-8414","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"article-number":"25158414251405397"}}