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Typical ocular colobomas predominantly involve the inferonasal quadrant, in accordance with the inferonasal location and closure pattern of the fetal fissure. Atypical colobomas outside this region are unusual and may complicate clinical evaluation and surgical planning. We report the case of a 49-year-old male with congenital inferonasal iris coloboma associated with a superotemporal lens coloboma, sectorial cataract, superior posterior subcapsular cataract and localized zonular absence. Ultrasound biomicroscopy demonstrated localized lens thickening and increased sphericity corresponding to the area of zonular defect. Given the limited extent of zonular involvement and intraoperative capsular bag stability, phacoemulsification with in-the-bag intraocular lens implantation was performed without additional capsular support. Postoperatively, the intraocular lens remained well centered during two-year follow-up, and best-corrected visual acuity improved significantly.<\/jats:p>","DOI":"10.1177\/25158414261487062","type":"journal-article","created":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:22:15Z","timestamp":1788308535000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["An unusual case of iris and lens colobomas: A case report"],"prefix":"10.1177","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0587-0550","authenticated-orcid":false,"given":"Cong","family":"Ren","sequence":"first","affiliation":[{"name":"College of Ophthalmology and Optometry, Shandong University of Traditional Chinese Medicine"},{"name":"Department of Vitreoretinal Surgery, Shandong University of Traditional Chinese Medicine Affiliated Eye Hospital"},{"name":"Experimental Center, Shandong Academy of Eye Disease Prevention and Therapy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-5919-5120","authenticated-orcid":false,"given":"Zhang-Chen-Xi","family":"Gu","sequence":"additional","affiliation":[{"name":"College of Ophthalmology and Optometry, Shandong University of Traditional Chinese Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5852-7268","authenticated-orcid":false,"given":"Jun-Guo","family":"Guo","sequence":"additional","affiliation":[{"name":"Experimental Center, Shandong Academy of Eye Disease Prevention and Therapy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-1217-8657","authenticated-orcid":false,"given":"Jing","family":"Pang","sequence":"additional","affiliation":[{"name":"Department of Vitreoretinal Surgery, Shandong University of Traditional Chinese Medicine Affiliated Eye Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7879-8003","authenticated-orcid":false,"given":"Bin","family":"Guo","sequence":"additional","affiliation":[{"name":"College of Ophthalmology and Optometry, Shandong University of Traditional Chinese Medicine"},{"name":"Department of Vitreoretinal Surgery, Shandong University of Traditional Chinese Medicine Affiliated Eye Hospital"},{"name":"Experimental Center, Shandong Academy of Eye Disease Prevention and Therapy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2230-5609","authenticated-orcid":false,"given":"Zhong-En","family":"Li","sequence":"additional","affiliation":[{"name":"College of Ophthalmology and Optometry, Shandong University of Traditional Chinese Medicine"},{"name":"Department of Vitreoretinal Surgery, Shandong University of Traditional Chinese Medicine Affiliated Eye Hospital"},{"name":"Experimental Center, Shandong Academy of Eye Disease Prevention and Therapy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,9,1]]},"reference":[{"key":"e_1_3_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6257(00)00151-X"},{"key":"e_1_3_7_3_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1007246"},{"key":"e_1_3_7_4_2","first-page":"11","volume-title":"Ocular Anatomy, Embryology and Teratology","author":"Ozanics V","year":"1982","unstructured":"Ozanics V, Jakobiec FA. Prenatal development of the eye and its adnexa. In: Jakobiec FA (ed). Ocular Anatomy, Embryology and Teratology. Harper & Row, 1982, pp. 11\u201396."},{"key":"e_1_3_7_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gde.2015.02.004"},{"key":"e_1_3_7_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41433-021-01501-5"},{"key":"e_1_3_7_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.31831"},{"key":"e_1_3_7_8_2","volume-title":"Vaughan & Asbury's General Ophthalmology","author":"Riordan-Eva P","year":"2011","unstructured":"Riordan-Eva P, Cunningham ET. 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