{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T09:04:22Z","timestamp":1789376662988,"version":"build-2803163510"},"reference-count":33,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ophthalmol Eye Dis"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Ocular conditions are often managed with eye drops but conventional dispensers may be difficult to use for some.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>A novel device has been designed to overcome limitations of traditional eye drop dispensers, and its ability to deliver artificial tears was tested.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>A single centre, prospective study of 24 patients with Dry Eye Disease (DED).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Regular users of artificial tears tested the novel dispenser over 4 weeks, evaluating: DED symptoms with the Dry Eye Questionnaire 5; ocular parameters including the non-invasive tear breakup time (NI-TBUT), the Schirmer I test and surface staining; and tear meniscus parameters (height, depth and area measured by AS-OCT before and after application). The patients used questionnaires to evaluate the usability and their satisfaction with the dispenser, and report any adverse reactions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Tear stability improved after 4 weeks using the dispenser, with a significantly higher NI-TBUT-first (6.48 \u00b13.65 s) and NI-TBUT-average (7.45 \u00b13.59 s) relative to baseline (4.52 \u00b13.18 and 5.95 \u00b13.39, respectively: p=0.001), coupled to milder ocular surface staining (0.54 \u00b10.65) relative to baseline (1.08 \u00b10.77: p=0.042). Artificial tear instillation using the dispenser significantly improved tear meniscus parameters, which persisted for \u22655 min, and the lower mean DEQ-5 score after 4 weeks (9.79 \u00b13.23) relative to baseline (11.20 \u00b13.37: p=0.006) indicated DED symptoms also improved. The patients rated the new dispenser as very easy (58%) or easy (33.3%) to use, and many felt very comfortable using it. Patients were satisfied (54.2%) or very satisfied (16.7%) with the new dispenser, 87.5% preferring it over conventional systems (p&lt;0.001) and with a desire to continue using it. No adverse reactions were reported.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The Beat the Blink\u2122 dispenser was feasible, easy to use, well tolerated, and highly accepted over 4 weeks. Clinical signs and patient-reported symptoms improved during use with preservative-free artificial tears.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/25158414261489406","type":"journal-article","created":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T07:00:22Z","timestamp":1789196422000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of the usability, efficacy and safety of a novel ophthalmic eye drop dispenser designed to deliver preservative-free artificial tears for the treatment of dry eye disease"],"prefix":"10.1177","volume":"18","author":[{"given":"Gamze","family":"Ozkan","sequence":"first","affiliation":[{"name":"Marmara University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesus","family":"Pujol-Marti","sequence":"additional","affiliation":[{"name":"Chief Scientific Officer, i.com medical"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-6163-7841","authenticated-orcid":false,"given":"Stefan","family":"Hellbardt","sequence":"additional","affiliation":[{"name":"Global Market Development, Aptar Radolfzell GmbH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Birkhoff","sequence":"additional","affiliation":[{"name":"Global Market Development, Aptar Radolfzell GmbH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Semra","family":"Akkaya Turhan","sequence":"additional","affiliation":[{"name":"Ac\u0131badem Mehmet Ali Ayd\u0131nlar University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,9,12]]},"reference":[{"key":"e_1_3_7_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/bph.14024"},{"key":"e_1_3_7_3_2","doi-asserted-by":"publisher","DOI":"10.4103\/joco.joco_308_22"},{"key":"e_1_3_7_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/ICU.0000000000000451"},{"key":"e_1_3_7_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41433-019-0665-y"},{"key":"e_1_3_7_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/IJG.0b013e31820bd2e1"},{"key":"e_1_3_7_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00410700"},{"key":"e_1_3_7_8_2","doi-asserted-by":"publisher","DOI":"10.1517\/17425247.3.2.275"},{"key":"e_1_3_7_9_2","doi-asserted-by":"publisher","DOI":"10.1080\/08164622.2024.2361781"},{"key":"e_1_3_7_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(02)01967-X"},{"key":"e_1_3_7_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/IJG.0b013e31829e1b8b"},{"key":"e_1_3_7_12_2","doi-asserted-by":"publisher","DOI":"10.2165\/00019053-200725040-00003"},{"key":"e_1_3_7_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10238-021-00728-6"},{"key":"e_1_3_7_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kep141"},{"key":"e_1_3_7_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtos.2014.12.001"},{"key":"e_1_3_7_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtos.2017.05.008"},{"key":"e_1_3_7_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtos.2017.05.003"},{"key":"e_1_3_7_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtos.2017.05.006"},{"key":"e_1_3_7_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1475-1313.2009.00683.x"},{"key":"e_1_3_7_20_2","doi-asserted-by":"publisher","DOI":"10.2147\/OPTO.S350185"},{"key":"e_1_3_7_21_2","doi-asserted-by":"publisher","DOI":"10.4103\/IJO.IJO_2818_22"},{"key":"e_1_3_7_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/aos.17500"},{"key":"e_1_3_7_23_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-147-8-200710160-00010"},{"key":"e_1_3_7_24_2","doi-asserted-by":"publisher","DOI":"10.4103\/2231-4040.85540"},{"key":"e_1_3_7_25_2","first-page":"71","article-title":"Reduction of Eyedrop Volume for Topical Ophthalmic Medications with the Nanodropper Bottle Adaptor","volume":"16","author":"St PDM","year":"2023","unstructured":"St PDM, Steger JS, Patnaik JL, et al. 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