{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T16:02:38Z","timestamp":1793116958483,"version":"4.5.0"},"reference-count":89,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Genet Epigenet"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>\n                    The Wnt family is a large class of highly conserved cysteine-rich secretory glycoproteins that play a vital role in various cellular and physiological courses through different signaling pathways during embryogenesis and tissue homeostasis 3. Wnt5a is a secreted glycoprotein that belongs to the noncanonical Wnt family and is involved in a wide range of developmental and tissue homeostasis. A growing body of evidence suggests that Wnt5a affects embryonic development, signaling through various receptors, starting with the activation of \u03b2-catenin by Wnt5a. In addition to affecting planar cell polarity and Ca\n                    <jats:sup>2+<\/jats:sup>\n                    pathways, \u03b2-catenin also includes multiple signaling cascades that regulate various cell functions. Secondly, Wnt5a can bind to Ror receptors to mediate noncanonical Wnt signaling and a significant ligand for Ror2 in vertebrates. Consistent with the multiple functions of Wnt5A\/Ror2 signaling, Wnt5A knockout mice exhibited various phenotypic defects, including an inability to extend the anterior and posterior axes of the embryo. Numerous essential roles of Wnt5a\/Ror2 in development have been demonstrated. Therefore, Ror signaling pathway become a necessary target for diagnosing and treating human diseases. The Wnt5a- Ror2 signaling pathway as a critical factor has attracted extensive attention.\n                  <\/jats:p>","DOI":"10.1177\/25168657211064232","type":"journal-article","created":{"date-parts":[[2022,1,31]],"date-time":"2022-01-31T03:56:46Z","timestamp":1643601406000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":39,"title":["Roles of Wnt Signaling Pathway and ROR2 Receptor in Embryonic Development: An Update Review Article"],"prefix":"10.1177","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0671-9975","authenticated-orcid":false,"given":"Rui","family":"Guo","sequence":"first","affiliation":[{"name":"Qingdao University, Qingdao, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quan Sheng","family":"Xing","sequence":"additional","affiliation":[{"name":"Qingdao University-Affiliated Hospital of Women and Children, Qingdao, 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