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His physicians believed that the subsequent dementia was related to the infection. After death at 24 years of age, postmortem brain examination revealed abundant AD-type senile plaques and fibrils, formally confirming AD. Other potential causes of early-onset dementia are discussed, but these are distinct from patient E.H. This case is pertinent regarding the current debate about the potential role of infection in AD.\n                  <\/jats:p>","DOI":"10.1177\/25424823241298530","type":"journal-article","created":{"date-parts":[[2025,1,14]],"date-time":"2025-01-14T21:53:29Z","timestamp":1736891609000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["A historic case of relapsing-remitting Alzheimer's disease in an adolescent attributed to scarlet fever"],"prefix":"10.1177","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9698-9834","authenticated-orcid":false,"given":"Richard","family":"Lathe","sequence":"first","affiliation":[{"name":"Division of Infection Medicine, University of Edinburgh Medical School, Little France, Edinburgh, UK"},{"name":"Alzheimer's Pathobiome Initiative, Wake Forest, NC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4645-5153","authenticated-orcid":false,"given":"Brian","family":"Balin","sequence":"additional","affiliation":[{"name":"Alzheimer's Pathobiome Initiative, Wake Forest, NC, USA"},{"name":"Department of Bio-Medical Sciences, Philadelphia College of Osteopathic Medicine, Philadelphia, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,1,14]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.4.1.48"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneurpsyc.1929.02210220076003"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-007-0200-2"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ncl.2017.01.005"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.psc.2015.01.002"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000042088.22694.E3"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1212\/NXG.0000000000000507"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-221065"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.20.1.11"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12236"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awad242"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410050311"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(97)00303-1"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1136\/pmj.78.916.63"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-020-00977-8"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-130413"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-220679"},{"key":"e_1_3_4_19_2","first-page":"10","article-title":"Assessment of amyloid beta in pathologically confirmed frontotemporal dementia syndromes","volume":"9","author":"Tan RH","year":"2017","unstructured":"Tan RH, Kril JJ, Yang Y, et al. 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