{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T12:27:55Z","timestamp":1789475275639,"version":"build-2803163510"},"reference-count":82,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T00:00:00Z","timestamp":1736726400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T00:00:00Z","timestamp":1736726400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer's Disease Reports"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Clinical distinction between Alzheimer's disease (AD) and dementia with Lewy bodies (DLB) poses significant challenges due to pathological comorbidity. Similar ages of onset and overlapping cognitive and psychiatric symptoms can lead to diagnostic inaccuracy and inappropriate treatment recommendations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Identify the best combination of clinical and neuropsychological predictors of AD, DLB, and mixed DLB\/AD neuropathology in dementia patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Using the National Alzheimer's Coordinating Center dataset, we selected either pure AD (\n                      <jats:italic toggle=\"yes\">n\u2009=\u2009<\/jats:italic>\n                      189), DLB (\n                      <jats:italic toggle=\"yes\">n\u2009<\/jats:italic>\n                      =\u200921), or mixed DLB\/AD (\n                      <jats:italic toggle=\"yes\">n\u2009<\/jats:italic>\n                      =\u200942) patients on autopsy. Neuropsychological and clinical predictors, including core clinical features of DLB, were entered into multivariable logistic regressions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Gait disturbances (odds ratio (OR)\u2009=\u200919.32; p\u2009=\u20090.01), visual-spatial complaints (OR = 6.06; p\u2009=\u20090.03), and visual hallucinations (OR = 31.06; p\u2009=\u20090.002) predicted DLB compared to AD, along with better memory (OR = 3.42; p\u2009=\u20090.003), naming (OR = 3.35; p\u2009=\u20090.002), and worse processing speed (OR = 0.51; p\u2009=\u20090.01). When comparing DLB to DLB\/AD, gait disturbances (OR = 6.33; p\u2009=\u20090.01), increased depressive symptoms (OR = 1.44; p\u2009=\u20090.03), and better memory (OR = 3.01; p\u2009=\u20090.004) predicted DLB. Finally, rapid eye movement sleep behavior disorder (RBD) (OR = 6.44; p\u2009=\u20090.004), parkinsonism severity (OR = 1.07; p\u2009=\u20090.02), and lower depressive symptoms (OR = 0.70; p\u2009=\u20090.006) and memory impairment (OR = 0.57; p\u2009=\u20090.02) distinguished DLB\/AD from AD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our study converges with prior research suggesting specific neuropsychological and clinical features can help distinguish DLB from AD. Neuropsychological differentiation becomes more challenging among mixed pathologies and in advanced cognitive impairment, although the presence of RBD and parkinsonism distinguished DLB. Earlier clinical assessment and incorporation of in vivo and postmortem biomarkers should enhance diagnostic accuracy and understanding of disease characteristics, offering significant relevance for disease-modifying treatments.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/25424823241304386","type":"journal-article","created":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T04:07:03Z","timestamp":1736741223000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Neuropsychological and clinical indicators of Lewy body and Alzheimer's pathology"],"prefix":"10.1177","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1436-9004","authenticated-orcid":false,"given":"Austin J","family":"Simpson","sequence":"first","affiliation":[{"name":"Department of Clinical Psychology, Pacific University, Hillsboro, OR, USA"},{"name":"Renown Health\/University of Nevada, School of Medicine, Department of Behavioral Health, Reno, NV, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5057-5094","authenticated-orcid":false,"given":"Kathryn A","family":"Wyman-Chick","sequence":"additional","affiliation":[{"name":"HealthPartners\/Park Nicollet Struthers Parkinson's Center, Department of Neurology, Golden Valley, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael S","family":"Daniel","sequence":"additional","affiliation":[{"name":"Department of Clinical Psychology, Pacific University, Hillsboro, OR, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,1,13]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291713000494"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00462-6"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000004058"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000187889.17253.b1"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.005"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.2000.tb00269.x"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(16)30291-5"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/nlw070"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000065889.42856.F2"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.58.2.186"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0217566"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.51.2.351"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000200259"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.305.6855.673"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-201187"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11065-016-9334-0"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000011699"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0010-9452(08)70489-1"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.10633"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh725"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2012-304381"},{"key":"e_1_3_5_23_2","doi-asserted-by":"publisher","DOI":"10.3988\/jcn.2011.7.1.19"},{"key":"e_1_3_5_24_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-010-5453-3"},{"key":"e_1_3_5_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2016.07.008"},{"key":"e_1_3_5_26_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617716000436"},{"key":"e_1_3_5_27_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000165987.89198.65"},{"key":"e_1_3_5_28_2","doi-asserted-by":"publisher","DOI":"10.1111\/ane.13028"},{"key":"e_1_3_5_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12120"},{"key":"e_1_3_5_30_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-018-0356-0"},{"key":"e_1_3_5_31_2","doi-asserted-by":"publisher","DOI":"10.1177\/0891988703258671"},{"key":"e_1_3_5_32_2","article-title":"Effects of white matter hyperintensities, neuropsychiatric symptoms, and cognition on activities of daily living: differences between Alzheimer\u2019s disease and dementia with Lewy bodies","volume":"14","author":"Mirza SS","year":"2022","unstructured":"Mirza SS, Saeed U, Ramirez J, et al. 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