{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T06:57:57Z","timestamp":1785308277576,"version":"3.55.0"},"reference-count":46,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer's Disease Reports"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Previous observational studies demonstrated a link existed between traumatic brain injury (TBI) and cerebral disease and multisystem complications, such as dementia, pneumonia, and gastrointestinal disease, but they could be confused by confounding and reverse causality<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We aimed to figure out the causal correlation between TBI and the following complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Database concerning TBI and complications from genome-wide association study (GWAS) and two-sample Mendelian randomization (MR) analysis was employed to examine whether TBI was causally associated with the risk of some complications. All the analysis was carried out through R, version 4.3.3.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>MR analyses indicated that any dementia has a promotional effect on TBI (OR\u2009=\u20091.067, 95% CI, 1.011\u20131.123, p\u2009=\u20090.017). However, there was no causal genetically association between TBI and Alzheimer's disease (AD), Parkinson's disease (PD), pneumonia, or gastrointestinal disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Contrary to observational studies, our results uncovered little causal association between TBI and PD, AD, depression, pneumonia, and gastrointestinal diseases. Interestingly, we found any dementia might be the risk of TBI, which was a new discovery.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/25424823241304393","type":"journal-article","created":{"date-parts":[[2024,12,23]],"date-time":"2024-12-23T04:28:17Z","timestamp":1734928097000},"page":"1670-1676","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Exploring causal relationship of traumatic brain injury and comorbidities: A Mendelian randomization study"],"prefix":"10.1177","volume":"8","author":[{"given":"Xiaohang","family":"Zhang","sequence":"first","affiliation":[{"name":"School of Integrated Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenze","family":"Wu","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory for High Technology Research of TCM Formulae, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-9257-7335","authenticated-orcid":false,"given":"Yaqing","family":"Mao","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory for High Technology Research of TCM Formulae, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-2677-5687","authenticated-orcid":false,"given":"Jiaxin","family":"Cheng","sequence":"additional","affiliation":[{"name":"School of Integrated Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zixuan","family":"Zhou","sequence":"additional","affiliation":[{"name":"School of Integrated Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaqi","family":"Tang","sequence":"additional","affiliation":[{"name":"The First Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4419-3305","authenticated-orcid":false,"given":"Qiulong","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Shenzhen Hospital of Integrated Traditional Chinese and Western Medicine, Shenzhen, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Yan","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory for High Technology Research of TCM Formulae, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,12,1]]},"reference":[{"key":"bibr1-25424823241304393","unstructured":"Centers for Disease Control and Prevention. 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