{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T16:07:05Z","timestamp":1777133225436,"version":"3.51.4"},"reference-count":134,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer's Disease Reports"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p> Alzheimer's disease (AD) is a neurodegenerative disorder characterized by cognitive decline and behavior impairments. Despite recent approvals of anti-amyloid antibodies, there remains a need for disease modifying and easily accessible therapies. Emerging evidence suggests that targeting the endocannabinoid system may hold promise for AD therapy as it plays a crucial role in different physiological processes, including learning, memory and anxiety, as well as inflammatory and immune responses. <\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p> In this study, we investigated the therapeutic potential of the synthetic cannabinoid WIN 55,212-2 on memory deficits in Tg4-42 transgenic mice. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p> Tg4-42 mice were assigned to two treatment groups to investigate the preventive effects of WIN 55,212-2 after a prolonged washout period, as well as the therapeutic effects of WIN 55,212-2 on behavior. Furthermore, the effects of WIN 55,212-2 treatment on AD pathology, including inflammation, amyloid-\u03b2 load, neurogenesis, and brain glucose metabolism, were evaluated. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> Therapeutic WIN 55,212-2 treatment rescued recognition memory and spatial reference deficits in Tg4-42 mice. Furthermore, therapeutic WIN 55,212-2 administration improved motor performance. In addition, preventative WIN 55,212-2 treatment rescued spatial learning and reference memory deficits. Importantly, WIN 55,212-2 treatment did not affect anxiety-like behavior. However, therapeutic and preventative WIN 55,212-2 treatment resulted in an increase locomotor activity and swimming speed in Tg4-42 mice. WIN-treatment reduced microgliosis in the hippocampus of preventively treated mice and rescued brain glucose metabolism in therapeutically treated Tg4-42 mice. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p> Our findings emphasize the therapeutic promise of the synthetic cannabinoid WIN 55,212-2 in alleviating behavioral and cognitive deficits linked to AD. <\/jats:p><\/jats:sec>","DOI":"10.1177\/25424823241306770","type":"journal-article","created":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T06:50:08Z","timestamp":1740725408000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Chronic exposure to a synthetic cannabinoid improves cognition and increases locomotor activity in Tg4-42 Alzheimer's disease mice"],"prefix":"10.1177","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-3220-9460","authenticated-orcid":false,"given":"Frederik W","family":"Ott","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, University Medical Center, Georg-August-University, Goettingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marius E","family":"Sichler","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, University Medical Center, Georg-August-University, Goettingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0057-5037","authenticated-orcid":false,"given":"Caroline","family":"Bouter","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, University Medical Center G\u00f6ttingen, Goettingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marzieh","family":"Enayati","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, University Medical Center, Georg-August-University, Goettingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1492-5330","authenticated-orcid":false,"given":"Jens","family":"Wiltfang","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, University Medical Center, Georg-August-University, Goettingen, Germany"},{"name":"Clincal Science Group, German Center for Neurodegenerative Diseases (DZNE), Goettingen, Germany"},{"name":"Neurosciences and Signaling Group, Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Aveiro, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas A","family":"Bayer","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, University Medical Center, Georg-August-University, Goettingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9126-3356","authenticated-orcid":false,"given":"Nicola","family":"Beindorff","sequence":"additional","affiliation":[{"name":"Berlin Experimental Radionuclide Imaging Center (BERIC), Charit\u00e9 - Universit\u00e4tsmedizin Berlin, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maximilian J","family":"L\u00f6w","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, University Medical Center, Georg-August-University, Goettingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-3893-598X","authenticated-orcid":false,"given":"Yvonne","family":"Bouter","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, University Medical Center, Georg-August-University, Goettingen, Germany"},{"name":"Department of Nuclear Medicine, University Medical Center G\u00f6ttingen, Goettingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,2,27]]},"reference":[{"key":"bibr1-25424823241306770","doi-asserted-by":"publisher","DOI":"10.31887\/DCNS.2013.15.4\/hjahn"},{"key":"bibr2-25424823241306770","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2020.06.016"},{"key":"bibr3-25424823241306770","doi-asserted-by":"publisher","DOI":"10.1016\/j.ncl.2017.01.005"},{"key":"bibr4-25424823241306770","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001238"},{"key":"bibr5-25424823241306770","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-021-01249-0"},{"key":"bibr6-25424823241306770","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R118.003999"},{"key":"bibr7-25424823241306770","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2021.708119"},{"key":"bibr8-25424823241306770","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.82.12.4245"},{"key":"bibr9-25424823241306770","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-010-0690-1"},{"key":"bibr10-25424823241306770","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-21641-1"},{"key":"bibr11-25424823241306770","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2021.710579"},{"key":"bibr12-25424823241306770","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-023-01858-9"},{"key":"bibr13-25424823241306770","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-023-01405-0"},{"key":"bibr14-25424823241306770","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2023.101996"},{"key":"bibr15-25424823241306770","doi-asserted-by":"publisher","DOI":"10.31128\/AJGP-04-21-5939"},{"key":"bibr16-25424823241306770","first-page":"682","volume":"12","author":"Haddad F","year":"2022","journal-title":"Life (Basel)"},{"key":"bibr17-25424823241306770","doi-asserted-by":"publisher","DOI":"10.1007\/s40429-022-00438-3"},{"key":"bibr18-25424823241306770","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2022.154485"},{"key":"bibr19-25424823241306770","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23063344"},{"key":"bibr20-25424823241306770","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2011.6"},{"key":"bibr21-25424823241306770","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2015.07.028"},{"key":"bibr22-25424823241306770","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-023-02607-8"},{"key":"bibr23-25424823241306770","doi-asserted-by":"publisher","DOI":"10.1093\/alcalc\/agh110"},{"key":"bibr24-25424823241306770","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2022.962922"},{"key":"bibr25-25424823241306770","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-540-88955-7_8"},{"key":"bibr26-25424823241306770","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-016-0313-5"},{"key":"bibr27-25424823241306770","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20235905"},{"key":"bibr28-25424823241306770","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23147891"},{"key":"bibr29-25424823241306770","doi-asserted-by":"publisher","DOI":"10.4155\/fmc.09.93"},{"key":"bibr30-25424823241306770","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-9-8"},{"key":"bibr31-25424823241306770","doi-asserted-by":"publisher","DOI":"10.1002\/glia.20108"},{"key":"bibr32-25424823241306770","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines9091270"},{"key":"bibr33-25424823241306770","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0122843"},{"key":"bibr34-25424823241306770","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2012.05.013"},{"key":"bibr35-25424823241306770","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-013-1129-2"},{"key":"bibr36-25424823241306770","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2018.00425"},{"key":"bibr37-25424823241306770","doi-asserted-by":"publisher","DOI":"10.1038\/srep17338"},{"key":"bibr38-25424823241306770","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23040718"},{"key":"bibr39-25424823241306770","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2019.00107"},{"key":"bibr40-25424823241306770","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-09270-1"},{"key":"bibr41-25424823241306770","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-201204"},{"key":"bibr42-25424823241306770","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-020-02120-z"},{"key":"bibr43-25424823241306770","volume":"75","author":"Deacon RM","year":"2013","journal-title":"J Vis Exp"},{"key":"bibr44-25424823241306770","doi-asserted-by":"publisher","DOI":"10.9758\/cpn.2020.18.3.341"},{"key":"bibr45-25424823241306770","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-8994-2_4"},{"key":"bibr46-25424823241306770","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2019.00094"},{"key":"bibr47-25424823241306770","doi-asserted-by":"publisher","DOI":"10.3390\/ijms231911159"},{"key":"bibr48-25424823241306770","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(03)01274-3"},{"key":"bibr49-25424823241306770","doi-asserted-by":"publisher","DOI":"10.1186\/2051-5960-1-56"},{"key":"bibr50-25424823241306770","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2010.02.012"},{"key":"bibr51-25424823241306770","doi-asserted-by":"publisher","DOI":"10.1177\/1759091419892692"},{"key":"bibr52-25424823241306770","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2022.105684"},{"key":"bibr53-25424823241306770","doi-asserted-by":"publisher","DOI":"10.3390\/biom11091361"},{"key":"bibr54-25424823241306770","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2016.02.003"},{"key":"bibr55-25424823241306770","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2020.147135"},{"key":"bibr56-25424823241306770","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-007-8006-8"},{"key":"bibr57-25424823241306770","doi-asserted-by":"publisher","DOI":"10.3390\/biology10060542"},{"key":"bibr58-25424823241306770","doi-asserted-by":"publisher","DOI":"10.2174\/157015907780866884"},{"key":"bibr59-25424823241306770","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines9050484"},{"key":"bibr60-25424823241306770","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.005"},{"key":"bibr61-25424823241306770","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2020.07.045"},{"key":"bibr62-25424823241306770","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4540-04.2005"},{"key":"bibr63-25424823241306770","doi-asserted-by":"publisher","DOI":"10.1126\/science.274.5284.99"},{"key":"bibr64-25424823241306770","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-199709000-00002"},{"key":"bibr65-25424823241306770","doi-asserted-by":"publisher","DOI":"10.1124\/mol.111.071290"},{"key":"bibr66-25424823241306770","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4311"},{"key":"bibr67-25424823241306770","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.9.3984"},{"key":"bibr68-25424823241306770","doi-asserted-by":"publisher","DOI":"10.1124\/mol.54.3.459"},{"key":"bibr69-25424823241306770","doi-asserted-by":"publisher","DOI":"10.1046\/j.0953-816x.2001.01536.x"},{"key":"bibr70-25424823241306770","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19-08-02987.1999"},{"key":"bibr71-25424823241306770","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-17-06475.2001"},{"key":"bibr72-25424823241306770","doi-asserted-by":"publisher","DOI":"10.1038\/35097089"},{"key":"bibr73-25424823241306770","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2013.09.001"},{"key":"bibr74-25424823241306770","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2007.01.005"},{"key":"bibr75-25424823241306770","first-page":"55718","volume":"126","author":"Lueptow LM","year":"2017","journal-title":"J Vis Exp"},{"key":"bibr76-25424823241306770","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2009.12.022"},{"key":"bibr77-25424823241306770","doi-asserted-by":"publisher","DOI":"10.1037\/a0018320"},{"key":"bibr78-25424823241306770","doi-asserted-by":"publisher","DOI":"10.1016\/j.nlm.2004.03.005"},{"key":"bibr79-25424823241306770","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2016.00422"},{"key":"bibr80-25424823241306770","doi-asserted-by":"publisher","DOI":"10.1093\/bmb\/ldw035"},{"key":"bibr81-25424823241306770","doi-asserted-by":"publisher","DOI":"10.1053\/j.semnuclmed.2023.08.002"},{"key":"bibr82-25424823241306770","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines10020305"},{"key":"bibr83-25424823241306770","doi-asserted-by":"publisher","DOI":"10.1017\/neu.2018.11"},{"key":"bibr84-25424823241306770","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-04600-1"},{"key":"bibr85-25424823241306770","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2014.02.014"},{"key":"bibr86-25424823241306770","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2009.62"},{"key":"bibr87-25424823241306770","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2007.06.007"},{"key":"bibr88-25424823241306770","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2017.00293"},{"key":"bibr89-25424823241306770","doi-asserted-by":"publisher","DOI":"10.1080\/09540260902782810"},{"key":"bibr90-25424823241306770","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-1166(199709)12:9<913::AID-GPS663>3.0.CO;2-D"},{"key":"bibr91-25424823241306770","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0002202"},{"key":"bibr92-25424823241306770","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2014.01.019"},{"key":"bibr93-25424823241306770","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0706157"},{"key":"bibr94-25424823241306770","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-011-2342-0"},{"key":"bibr95-25424823241306770","doi-asserted-by":"publisher","DOI":"10.1016\/0091-3057(73)90005-1"},{"key":"bibr96-25424823241306770","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-007-5416-4_14"},{"key":"bibr97-25424823241306770","doi-asserted-by":"publisher","DOI":"10.1586\/ern.11.57"},{"key":"bibr98-25424823241306770","doi-asserted-by":"publisher","DOI":"10.1159\/000084555"},{"key":"bibr99-25424823241306770","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2010.06.011"},{"key":"bibr100-25424823241306770","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2017.09.009"},{"key":"bibr101-25424823241306770","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2010.05.027"},{"key":"bibr102-25424823241306770","doi-asserted-by":"publisher","DOI":"10.1515\/revneuro-2012-0041"},{"key":"bibr103-25424823241306770","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physiol.010908.163149"},{"key":"bibr104-25424823241306770","first-page":"230","volume":"25","author":"El Manira A","year":"2010","journal-title":"Physiology (Bethesda)"},{"key":"bibr105-25424823241306770","doi-asserted-by":"publisher","DOI":"10.1007\/3-540-26573-2_16"},{"key":"bibr106-25424823241306770","doi-asserted-by":"publisher","DOI":"10.1016\/0091-3057(95)02066-7"},{"key":"bibr107-25424823241306770","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-3057(97)00422-X"},{"key":"bibr108-25424823241306770","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(00)00044-3"},{"key":"bibr109-25424823241306770","doi-asserted-by":"publisher","DOI":"10.1007\/BF02244975"},{"key":"bibr110-25424823241306770","doi-asserted-by":"publisher","DOI":"10.1016\/S0376-8716(00)00205-2"},{"key":"bibr111-25424823241306770","doi-asserted-by":"publisher","DOI":"10.1111\/acer.14197"},{"key":"bibr112-25424823241306770","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2018.07.045"},{"key":"bibr113-25424823241306770","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-07-02511.2003"},{"key":"bibr114-25424823241306770","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2004.10.023"},{"key":"bibr115-25424823241306770","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-006-0676-9"},{"key":"bibr116-25424823241306770","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2019.00032"},{"key":"bibr117-25424823241306770","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2012.123"},{"key":"bibr118-25424823241306770","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.931384"},{"key":"bibr119-25424823241306770","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3565(25)13195-9"},{"key":"bibr120-25424823241306770","doi-asserted-by":"publisher","DOI":"10.1177\/026988110401800407"},{"key":"bibr121-25424823241306770","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines11010144"},{"key":"bibr122-25424823241306770","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.14549"},{"key":"bibr123-25424823241306770","doi-asserted-by":"publisher","DOI":"10.29252\/nirp.bcn.8.6.493"},{"key":"bibr124-25424823241306770","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-018-0064-2"},{"key":"bibr125-25424823241306770","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2016.04.011"},{"key":"bibr126-25424823241306770","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(98)00052-9"},{"key":"bibr127-25424823241306770","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2009.05.015"},{"key":"bibr128-25424823241306770","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-57290-1"},{"key":"bibr129-25424823241306770","doi-asserted-by":"publisher","DOI":"10.1111\/adb.12446"},{"key":"bibr130-25424823241306770","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2005.05.014"},{"key":"bibr131-25424823241306770","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-28-09374.2003"},{"key":"bibr132-25424823241306770","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(95)00319-E"},{"key":"bibr133-25424823241306770","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/11.8.728"},{"key":"bibr134-25424823241306770","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2017.02.021"}],"container-title":["Journal of Alzheimer's Disease Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/25424823241306770","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/25424823241306770","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/25424823241306770","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T06:50:14Z","timestamp":1740725414000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/25424823241306770"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":134,"alternative-id":["10.1177\/25424823241306770"],"URL":"https:\/\/doi.org\/10.1177\/25424823241306770","relation":{},"ISSN":["2542-4823","2542-4823"],"issn-type":[{"value":"2542-4823","type":"print"},{"value":"2542-4823","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"article-number":"25424823241306770"}}