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However, the relationship between ECAC and amyloid-\u03b2 (A\u03b2) deposition in older adults has not been fully understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aims to determine the relationship between ECAC and A\u03b2 deposition in very old adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      90 participants (87.2\u2009\u00b1\u20092.7 years old, 96% whites, 63% males) without dementia from an observational study were included in the cross-sectional analysis. A\u03b2 deposition in the brain was assessed using the\n                      <jats:sup>11<\/jats:sup>\n                      C-labeled Pittsburgh compound-B positron emission tomography (PiB-PET) scans performed in 2009 and 2011. Carotid artery plaque and ECAC status were measured via high-resolution carotid ultrasonography in 2011.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among the participants, 82 (91%) had carotid plaques, and 46 (51%) were globally A\u03b2 positive by PiB-PET. ECAC was less frequently observed in the A\u03b2 positive group compared to the A\u03b2 negative group (90% versus 81%, p\u2009=\u20090.3). The odds of A\u03b2 positivity in those with ECAC were 62% lower than in those without ECAC. However, the association was not statistically significant (OR\u2009=\u20090.38, 95% CI: [0.08, 1.76 ], p\u2009=\u20090.2).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In the population whose average age is older than 85 without dementia, there is no statistically significant association between ECAC and A\u03b2 deposition after adjusting for confounding factors. The relationship between ECAC and dementia in older adults warrants further analysis in a larger and more racially and ethnically diverse population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/25424823251358278","type":"journal-article","created":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T20:00:44Z","timestamp":1753300844000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Relationship between extracranial carotid artery calcification and amyloid-\u03b2 deposition in the brain among the very old: A retrospective study"],"prefix":"10.1177","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3778-5633","authenticated-orcid":false,"given":"Jiatong","family":"Li","sequence":"first","affiliation":[{"name":"Department of Epidemiology, School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7280-7781","authenticated-orcid":false,"given":"Emma","family":"Barinas-Mitchell","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuefang","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9978-1374","authenticated-orcid":false,"given":"Beth E","family":"Snitz","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0595-0203","authenticated-orcid":false,"given":"Brian","family":"Lopresti","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-9000-7216","authenticated-orcid":false,"given":"Alex","family":"DelBene","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7197-6321","authenticated-orcid":false,"given":"Akira","family":"Sekikawa","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8546-8256","authenticated-orcid":false,"given":"Oscar L","family":"Lopez","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,7,23]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_3_3_2_2","DOI":"10.1161\/STROKEAHA.121.035692"},{"doi-asserted-by":"publisher","key":"e_1_3_3_3_2","DOI":"10.3174\/ajnr.A5436"},{"key":"e_1_3_3_4_2","article-title":"Carotid artery calcification: what we know so far","volume":"13","author":"Ahmed M","year":"2021","unstructured":"Ahmed M, McPherson R, Abruzzo A, et al. 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