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Air pollutants may contribute to neurodegenerative processes through mechanisms such as oxidative stress, neuroinflammation, and disruption of the blood\u2013brain barrier.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Objective<\/jats:title>\n            <jats:p>\n              This review aims to systematically evaluate global cohort studies investigating the association between long-term exposure to key air pollutants\u2014specifically particulate matter (PM2.5), nitrogen dioxide (NO\n              <jats:sub>2<\/jats:sub>\n              ), and ozone (O\n              <jats:sub>3<\/jats:sub>\n              )\u2014and the risk of AD.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>A total of 31 peer-reviewed cohort studies were included based on a structured search strategy. We analyzed epidemiological outcomes, exposure assessment methodologies, and geographic trends. Additionally, a bibliometric analysis was conducted using VOSviewer to identify major contributors and emerging research themes.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Findings indicate a consistent association between PM2.5 exposure and increased risk of AD, independent of genetic predisposition and lifestyle factors. Proposed biological mechanisms include oxidative stress, microglial activation, blood\u2013brain barrier disruption, and amyloid-\u03b2 accumulation. Bibliometric mapping revealed regional concentration of research in North America, Europe, and East Asia, with increasing global interest over the past decade.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>There is mounting evidence linking air pollution to Alzheimer's disease. Advances in exposure assessment have improved the accuracy of epidemiological findings. Public health policies targeting air quality control and further studies on molecular and early-life exposures are essential to mitigate the neurotoxic effects of environmental pollutants.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1177\/25424823251368883","type":"journal-article","created":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T13:58:28Z","timestamp":1755093508000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["A bibliometric and systematic review of the global impact of air pollution on Alzheimer's disease: Insights from cohort studies"],"prefix":"10.1177","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2744-5101","authenticated-orcid":false,"given":"Faezeh","family":"Jahedi","sequence":"first","affiliation":[{"name":"Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran"},{"name":"Department of Environmental Health Engineering, School of Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5387-0761","authenticated-orcid":false,"given":"Gholamreza","family":"Goudarzi","sequence":"additional","affiliation":[{"name":"Department of Environmental Health Engineering, School of Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran"},{"name":"Environmental Technologies Research Center, Medical Basic Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9227-7562","authenticated-orcid":false,"given":"Mehdi","family":"Ahmadi","sequence":"additional","affiliation":[{"name":"Department of Environmental Health Engineering, School of Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran"},{"name":"Environmental Technologies Research Center, Medical Basic Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-1498-5472","authenticated-orcid":false,"given":"Farhad","family":"Safdari","sequence":"additional","affiliation":[{"name":"Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran"},{"name":"Department of Environmental Health Engineering, School of Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,8,13]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2023.115483"},{"key":"e_1_3_3_3_2","first-page":"223","article-title":"Systematic review of pulmonary toxicity induced by microplastics and nanoplastics: insights from in vivo and in vitro studies","volume":"37","author":"Fard NJH","year":"2025","unstructured":"Fard NJH, Jahedi F, Khaksar MA, et al. 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