{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T18:13:12Z","timestamp":1793643192413,"version":"4.5.1"},"reference-count":34,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T00:00:00Z","timestamp":1757030400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T00:00:00Z","timestamp":1757030400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["1R21AG070449-01"],"award-info":[{"award-number":["1R21AG070449-01"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer's Disease Reports"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>\n                      The presence of the apolipoprotein E4 (\n                      <jats:italic toggle=\"yes\">APOE4<\/jats:italic>\n                      ) allele and periodontal disease are independently correlated with higher levels of amyloid-\u03b2 and inflammation in the brain, worse cognition, and Alzheimer's disease.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>\n                      To assess whether the presence of the\n                      <jats:italic toggle=\"yes\">APOE4<\/jats:italic>\n                      allele modifies the relationship between IgG antibodies against periodontal microorganisms and cognitive function in older adults participating in the NHANES III study.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      This cross-sectional analysis was conducted among participants of the third National Health and Nutrition Examination Survey (NHANES III) (1988 to 1994), aged 60 years and older, with measurements of IgG antibodies against 19 periodontal microorganisms and\n                      <jats:italic toggle=\"yes\">APOE4<\/jats:italic>\n                      alleles (N\u2009=\u20091644).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Approximately 77.5% of participants carried no\n                      <jats:italic toggle=\"yes\">APOE4<\/jats:italic>\n                      allele, 20.0% had one allele, and 2.6% were homozygous. Mean cognitive scores were 16.1, 16.0, and 15.3 for non-carriers, heterozygous, and homozygous\n                      <jats:italic toggle=\"yes\">APOE4<\/jats:italic>\n                      allele carriers, respectively (p\u2009=\u20090.01). Antibody groups were not correlated with\n                      <jats:italic toggle=\"yes\">APOE4<\/jats:italic>\n                      carrier status. The Orange-Blue cluster (antibodies against\n                      <jats:italic toggle=\"yes\">E. nodatum, A. naeslundii<\/jats:italic>\n                      ) was correlated with cognitive score (Spearman r\u2009=\u20090.08, p\u2009&lt;\u20090.001), but not other antibody groups. In the multivariable-adjusted models,\n                      <jats:italic toggle=\"yes\">APOE4<\/jats:italic>\n                      alleles did not modify the associations between antibody clusters and cognitive score (p-interaction\u2009&gt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>\n                      Mean cognitive scores were lower among\n                      <jats:italic toggle=\"yes\">APOE4<\/jats:italic>\n                      carriers. The\n                      <jats:italic toggle=\"yes\">APOE4<\/jats:italic>\n                      allele did not modify associations between groups of IgG antibodies against periodontal microorganisms and cognition among older aged adults without cognitive impairment. These findings need to be verified in larger prospective studies.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/25424823251370770","type":"journal-article","created":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T10:41:17Z","timestamp":1757068877000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Apolipoprotein E4 allele, antibodies against periodontal microorganisms, and cognition in older adults"],"prefix":"10.1177","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1045-5079","authenticated-orcid":false,"given":"Anwar T.","family":"Merchant","sequence":"first","affiliation":[{"name":"University of South Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longgang","family":"Zhao","sequence":"additional","affiliation":[{"name":"University of South Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric Mishio","family":"Bawa","sequence":"additional","affiliation":[{"name":"University of South Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amirhossein Fakhre","family":"Yaseri","sequence":"additional","affiliation":[{"name":"University of South Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Lohman","sequence":"additional","affiliation":[{"name":"University of South Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajia","family":"Zhang","sequence":"additional","affiliation":[{"name":"University of South Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alyssa","family":"Clay-Gilmour","sequence":"additional","affiliation":[{"name":"University of South Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger D","family":"Newman-Norlund","sequence":"additional","affiliation":[{"name":"University of South Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julius","family":"Fridriksson","sequence":"additional","affiliation":[{"name":"University of South Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,9,5]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-016-1427-y"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3002156"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)61349-9"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2012.04.009"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2014.06.015"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-020-03764-w"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2018.11.009"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2007.01173.x"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2018.3597"},{"key":"e_1_3_3_11_2","first-page":"148","article-title":"Antibodies against periodontal microorganisms and cognition in older adults","volume":"8","author":"Merchant AT","year":"2023","unstructured":"Merchant AT, Yi F, Vidanapathirana NP, et al. 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