{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T19:21:39Z","timestamp":1783624899456,"version":"3.55.0"},"reference-count":99,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Hibah Fundamental Kemendikbud Republik Indonesia","award":["SK Nomor 825\/LL3\/AL.04\/2024"],"award-info":[{"award-number":["SK Nomor 825\/LL3\/AL.04\/2024"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer's Disease Reports"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>\n            Cognitive dysfunction in the elderly is not only a disease but also could be considered a preclinical condition of Alzheimer's disease (AD), one of the most common types of dementia in the elderly. Therefore, treatment such as early detection and management of risk factors that could slow and prevent the onset of dementia is necessary for the elderly. Estrogen reduces the risk of AD in postmenopausal women. It has also been shown to reduce amyloid-\u03b2 (A\u03b2) pathology in animal models of AD and suppress A\u03b2 secretion from neuronal tissue\n            <jats:italic>.<\/jats:italic>\n            Estrogen receptors are involved in cognitive processes such as learning and memory, the formation of the hippocampus, the amygdala, and the cerebral cortex. Hormone replacement therapy (HRT) could improve cognition and thus delay the development of AD. Giving HRT after 9 years has been shown to increase the risk of breast cancer two-fold and cardiovascular disease. Phytoestrogens are hormones found in plants that can be an alternative to HRT. One of the foods that contains phytoestrogens and is widely consumed in Indonesia is tempeh. Isoflavone is a dominant phytoestrogen, structurally an estrogen-like substance, and functionally similar to 17\u03b2-estradiol. In this review article, we will discuss the role of tempeh isoflavones in a mechanism pathway on cognition.\n          <\/jats:p>","DOI":"10.1177\/25424823251371284","type":"journal-article","created":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T11:32:41Z","timestamp":1756380761000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["The preventive role of tempeh isoflavones on menopausal women's cognitive function: A multiple mechanism pathway"],"prefix":"10.1177","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7053-1665","authenticated-orcid":false,"given":"Atik","family":"Kridawati","sequence":"first","affiliation":[{"name":"Public Health Postgraduate Program, Respati Indonesia University, East Jakarta, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Indrawati","sequence":"additional","affiliation":[{"name":"Hospital Administration Postgraduate Program, Respati Indonesia University, East Jakarta, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sugeng","family":"Hadisaputra","sequence":"additional","affiliation":[{"name":"Nursing Study Program, Faculty of Health Sciences, Respati Indonesia University, East Jakarta, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-0170-3416","authenticated-orcid":false,"given":"Asyifa Robiatul","family":"Adawiyah","sequence":"additional","affiliation":[{"name":"Public Health Study Program, Faculty of Health Sciences, Respati Indonesia University, East Jakarta, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,8,28]]},"reference":[{"key":"e_1_3_3_2_2","first-page":"25","volume-title":"Neuropsychological assessment","author":"Lezak MD","year":"2012","unstructured":"Lezak MD, Howieson DB, Bigler ED, et al. 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