{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T05:33:57Z","timestamp":1777613637408,"version":"3.51.4"},"reference-count":50,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100004600","name":"Kyungpook National University Hospital","doi-asserted-by":"publisher","award":["201602-NE-05"],"award-info":[{"award-number":["201602-NE-05"]}],"id":[{"id":"10.13039\/501100004600","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer's Disease Reports"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Alzheimer's disease (AD) is a neurodegenerative disease that causes a decline in cognitive functions, considerably affecting a patient's life. Recently, virtual reality (VR) technology has emerged as a new tool used in the cognitive training of patients with AD.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Objective<\/jats:title>\n            <jats:p>This study aimed to investigate the safety, feasibility, and clinical efficacy of VR-based cognitive training for patients with mild to moderate AD.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>Thirteen participants diagnosed with mild to moderate AD underwent VR training sessions by using the MentiTree software. Each session was conducted for 30\u2005min twice a week for 9 weeks (total of 540\u2005min). Cognitive functions were assessed before and after the intervention.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Although 1 of the 13 participants experienced adverse effects, the 9-week cognitive training was well tolerated and had a high feasibility of 93%\u00b124.65%. A tendency toward improvement was observed in the visual recognition memory of the participants (p\u2009=\u20090.034), but other domains did not significantly change.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>VR-based cognitive training is safely accepted by patients with mild to moderate AD. The potential of VR in AD treatment should be further explored using a randomized control group.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1177\/25424823251385901","type":"journal-article","created":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T17:58:41Z","timestamp":1759514321000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Preliminary study on the feasibility of virtual reality-based cognitive training on patients with mild to moderate Alzheimer's disease"],"prefix":"10.1177","volume":"9","author":[{"given":"HyeWon","family":"Jeong","sequence":"first","affiliation":[{"name":"Department of Neurology, Kyungpook National University Chilgok Hospital, Daegu, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongha","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Kyungpook National University Chilgok Hospital, Daegu, Korea"},{"name":"School of Medicine, Kyungpook National University, Daegu, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung-Eun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology, Kyungpook National University Chilgok Hospital, Daegu, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiyun","family":"Lim","sequence":"additional","affiliation":[{"name":"GL Co., Ltd, Daegu, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8849-920X","authenticated-orcid":false,"given":"Ho-Won","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Neurology, Kyungpook National University Chilgok Hospital, Daegu, Korea"},{"name":"Department of Neurology, School of Medicine, Kyungpook National University, Daegu, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,10,3]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201606210"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40120-022-00338-8"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2022.883549"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232213954"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1186\/alzrt189"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1479-8301.2007.00212.x"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1159\/000353443"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1037\/a0014342"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jagp.2014.04.009"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2012.04.012"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2025.116426"},{"key":"e_1_3_3_13_2","first-page":"304","article-title":"Brief introduction of virtual reality & its challenges","volume":"4","author":"Mandal S","year":"2013","unstructured":"Mandal S. 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