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Due to the lack of non-pharmacological and physiological treatments, cranial osteopathic manipulation (COM) poses a potential minimally invasive therapeutic choice. To understand the treatment and related effects objectively, we have established a technique to quantify the force applied during COM on an animal model of AD for the first time. Our results indicate that quantified COM can be applied to rodents to study behavioral and biochemical phenotype changes.<\/jats:p>","DOI":"10.1177\/25424823251393742","type":"journal-article","created":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T17:27:23Z","timestamp":1762968443000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["A preliminary study on the effect of quantified cranial osteopathic manipulation on wild-type and transgenic rat models of Alzheimer's disease"],"prefix":"10.1177","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-7956-4717","authenticated-orcid":false,"given":"De\u2019Yana","family":"Hines","sequence":"first","affiliation":[{"name":"Virginia Tech-Wake Forest University School of Biomedical Engineering and Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hope","family":"Tobey","sequence":"additional","affiliation":[{"name":"Edward Via Virginia College of Osteopathic Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Dugan","sequence":"additional","affiliation":[{"name":"Edward Via Virginia College of Osteopathic Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seth","family":"Boehringer","sequence":"additional","affiliation":[{"name":"Virginia Tech"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Helm","sequence":"additional","affiliation":[{"name":"Virginia Tech"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0422-3984","authenticated-orcid":false,"given":"Ramu","family":"Anandakrishnan","sequence":"additional","affiliation":[{"name":"Edward Via Virginia College of Osteopathic Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1638-6705","authenticated-orcid":false,"given":"Stephen","family":"Werre","sequence":"additional","affiliation":[{"name":"Virginia Tech"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pamela","family":"VandeVord","sequence":"additional","affiliation":[{"name":"Virginia Tech-Wake Forest University School of Biomedical Engineering and Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6151-2251","authenticated-orcid":false,"given":"Blaise M","family":"Costa","sequence":"additional","affiliation":[{"name":"Edward Via Virginia College of Osteopathic Medicine"},{"name":"Virginia Tech"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,11,12]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12362"},{"key":"e_1_3_3_3_2","unstructured":"Alzheimer\u2019s Association. 2025 Alzheimer\u2019s disease facts and figures https:\/\/www.alz.org\/getmedia\/ef8f48f9-ad36-48ea-87f9-b74034635c1e\/alzheimers-facts-and-figures.pdf."},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000160548.78317.29"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1592-13.2013"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.2008.00133.x"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.adv8269"},{"key":"e_1_3_3_8_2","article-title":"A review of recent advances in the management of Alzheimer\u2019s disease","volume":"16","author":"Thangwaritorn S","year":"2024","unstructured":"Thangwaritorn S, Lee C, Metchikoff E, et al. 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