{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T08:14:00Z","timestamp":1768378440063,"version":"3.49.0"},"reference-count":81,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"the Science &Technology Department of Jiangsu Province","award":["Grant No.BE2023778"],"award-info":[{"award-number":["Grant No.BE2023778"]}]},{"name":"the National Key R&D Program of China","award":["Nos.2023YFC3603605"],"award-info":[{"award-number":["Nos.2023YFC3603605"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer's Disease Reports"],"published-print":{"date-parts":[[2026,1]]},"abstract":"\n Background<\/jats:title>\n \n Social isolation (SI) is an established risk factor for Alzheimer's disease (AD) and cognitive decline. However, its stage-specific effects across the AD continuum, particularly at subjective cognitive decline (SCD) and mild cognitive impairment (MCI) stages, remain unquantified in Chinese populations. The sex-specific effects of SI on cognitive decline remain incompletely characterized. The apolipoprotein E (\n APOE<\/jats:italic>\n ) genotype is a driver of cognitive decline and dementia.\n <\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n To investigate social connection characteristics and gene distribution in individuals with SCD or MCI, examine their cross-sectional associations with cognitive function, and explore gender differences in SCD or MCI risk\/prevention.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n A community-based sample of 164 SCD and 84 MCI patients (July 2021\u2013Dec 2024) was assessed. Demographic, social connectivity,\n APOE<\/jats:italic>\n genotype and cognitive data were collected. Social connectivity,\n APOE<\/jats:italic>\n genotype and cognitive function were compared between groups. In the overall or male and female genders, Pearson correlation analyzed associations between social connectivity and cognitive scores. Sex-stratified multivariable models tested Lubben Social Network Scale (LSNS-6)-by-sex interactions on MCI risk.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n LSNS-6 scores showed weak-to-moderate correlations with Montreal Cognitive Assessment (\n r<\/jats:italic>\n \u2009=\u20090.140,\n p<\/jats:italic>\n \u2009=\u20090.027), Animal Verbal Fluency Test-Huashan (AVLT-H) delayed recall (\n r<\/jats:italic>\n \u2009=\u20090.129,\n p<\/jats:italic>\n \u2009=\u20090.043), AVLT-H recognition (\n r<\/jats:italic>\n \u2009=\u20090.190,\n p<\/jats:italic>\n \u2009=\u20090.003), Trail Making Test-B (\n r<\/jats:italic>\n \u2009=\u2009-0.132,\n p<\/jats:italic>\n \u2009=\u20090.038), Boston Naming Test (\n r<\/jats:italic>\n \u2009=\u20090.147,\n p<\/jats:italic>\n \u2009=\u20090.021), and Animal Verbal Fluency Test (\n r<\/jats:italic>\n \u2009=\u20090.148,\n p<\/jats:italic>\n \u2009=\u20090.020). Multivariable binary logistic regression analysis revealed the association between social network and MCI risk differed by sex (OR\n male<\/jats:sub>\n = 0.581; OR\n female<\/jats:sub>\n = 0.746;\n p<\/jats:italic>\n interaction<\/jats:sub>\n = 0.021).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n SI may exacerbate cognitive dysfunction in adults with SCD or MCI. Women leverage social connectivity into significantly greater neuroprotective gains compared to men.<\/jats:p>\n <\/jats:sec>\n \n Trial registration<\/jats:title>\n \n ChiCTR2300073429.\n https:\/\/www.chictr.org.cn\/bin\/project\/edit?pid=200381<\/jats:ext-link>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1177\/25424823251409405","type":"journal-article","created":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T18:11:20Z","timestamp":1768327880000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Social determinants of health, genetic biomarkers, and cognitive function in Chinese older adults with subjective cognitive decline and mild cognitive impairment: A cross-sectional analysis"],"prefix":"10.1177","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-2731-7610","authenticated-orcid":false,"given":"Chun-Xu","family":"Shi","sequence":"first","affiliation":[{"name":"School of Rehabilitation 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